Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis

• Published in: Oncotarget Vol. 7; no. 32; pp. 52530 - 52540
• Main Authors: Chen, Yang, Li, Jie, Mo, Zengnan
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 09.08.2016
• Subjects: Asian People - genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; Genetic Predisposition to Disease - genetics; Genotype; Humans; Male; Polymorphism, Single Nucleotide; Prostatic Neoplasms - genetics; Review; prostate cancer; polymorphism; rs1130409; APEX1

Prostate cancer (Pca) is a serious disease associated with considerable morbidity and mortality. As a causative factor, the Asp148Glu polymorphism has been identified in the apurinic/apyrimidinic endonuclease (APEX1) gene. However, the association among Asians is considered controversial. Evidence f...