Using the optimal method—explained variance weighted genetic risk score to predict the efficacy of folic acid therapy to hyperhomocysteinemia

• Published in: European journal of clinical nutrition Vol. 76; no. 7; pp. 943 - 949
• Main Authors: Chen, Xiaorui, Huang, Xiaowen, Zheng, Caifang, Wang, Xiliang, Zhang, Weidong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2022; Nature Publishing Group
• Subjects: 38; 38/39; 692/499; 692/700/478/2772; Acids; Betaine-homocysteine S-methyltransferase; Clinical Nutrition; Epidemiology; Folic acid; Hyperhomocysteinemia; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Methylenetetrahydrofolate reductase; Nucleotides; Prediction models; Public Health; Risk analysis; Risk factors; Single-nucleotide polymorphism; Vitamin B

Background Genetic risk score (GRS) is a useful way to explore genetic architectures and the relationships of complex diseases. Several studies had revealed many single nucleotide polymorphisms (SNPs) associated with the efficacy of folic acid treatment to hyperhomocysteinemia (HHcy). Methods We aim...