Age and gender differences in the urinary proteome of healthy subjects using the advantages of quantitative proteomics

• Published in: Clinical and experimental nephrology Vol. 29; no. 7; pp. 912 - 919
• Main Authors: Yamamoto, Keiko, Yamamoto, Tadashi
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.07.2025; Springer Nature B.V
• Subjects: Adult; Age; Age Factors; Aged; Aging - urine; Biomarkers; Biomarkers - urine; Chloroform; Diabetes mellitus; Female; Females; Gender; Gender differences; Healthy Volunteers; Humans; Kallikreins; Kidneys; Laboratories; Male; Mass spectroscopy; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Original Article; Protein structure; Proteome; Proteomes; Proteomics; Proteomics - methods; Quality control; Sex differences; Sex Factors; Trypsin; Urine; Urology; Young Adult; Japan; Germany; Urine; Biomarker; Quantitation; Proteomics

Background Advances in quantitative proteomics have enabled accurate and comprehensive quantification of proteins. In this study, urine from healthy volunteers was analyzed using this method to confirm the depth of protein identification and quantitative stability, and to examine changes in abundanc...