Respiratory failure in systemic sclerosis

Systemic sclerosis (SSc) can lead to dyspnea and respiratory failure through multiple mechanisms, making a precise diagnosis particularly challenging, especially amid the current COVID-19 pandemic. In this report, we present a case involving a 26-year-old female who had previously undiagnosed SSc. S...

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Published inRheumatology international Vol. 44; no. 11; pp. 2653 - 2658
Main Authors Landim, Joaquim Ivo Vasques Dantas, Franco, Andre Silva, Sampaio-Barros, Percival Degrava, Miossi, Renata, Medeiros-Ribeiro, Ana Cristina, Pereira, Rosa Maria R., Assad, Ana Paula Luppino
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2024
Springer Nature B.V
Subjects
Adult
Anemia
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antibodies
Blood pressure
Case Based Review
COVID-19
COVID-19 - complications
Cyclophosphamide - therapeutic use
Dyspnea
Edema
Emergency medical care
Enzymes
Female
Heart failure
Hemodialysis
Humans
Hypertension
Intubation
Kidneys
Lung diseases
Medicine
Medicine & Public Health
Pandemics
Renal Dialysis
Respiratory failure
Respiratory Insufficiency - etiology
Respiratory Insufficiency - therapy
Rheumatology
RNA polymerase
SARS-CoV-2
Scleroderma
Scleroderma, Systemic - complications
Severe acute respiratory syndrome coronavirus 2
Thrombocytopenia
COVID-19
Respiratory insufficiency
Interstitial lung diseases
Systemic sclerosis
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Summary:Systemic sclerosis (SSc) can lead to dyspnea and respiratory failure through multiple mechanisms, making a precise diagnosis particularly challenging, especially amid the current COVID-19 pandemic. In this report, we present a case involving a 26-year-old female who had previously undiagnosed SSc. She experienced acute respiratory failure necessitating orotracheal intubation. Following an extensive evaluation, the patient exhibited skin thickening, kidney failure, thrombocytopenia, microangiopathic anemia, and an antinuclear antibody with a nuclear fine speckled pattern at a titer of 1:320. A diagnosis of SSc complicated by scleroderma renal crisis (SRC) was established. The patient’s condition improved after undergoing hemodialysis, receiving an angiotensin-converting enzyme inhibitor, and undergoing cyclophosphamide treatment. Subsequently, she demonstrated sustained improvement during a follow-up period of 20 months.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1437-160X
0172-8172
1437-160X
DOI:10.1007/s00296-023-05482-4