Inhibitory effects of docosyl p-coumarate on DNA topoisomerase activity and human cancer cell growth

• Published in: International journal of oncology Vol. 37; no. 4; pp. 993 - 1000
• Main Authors: MIZUSHINA, Yoshiyuki, NISHIMURA, Katsumi, TAKENAKA, Yukiko, TAKEUCHI, Toshifumi, SUGAWARA, Fumio, YOSHIDA, Hiromi, TANAHASHI, Takao
• Format: Journal Article
• Language: English
• Published: Athens Editorial Academy of the International Journal of Oncology 01.10.2010
• Subjects: Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis - drug effects; Biological and medical sciences; Cell Cycle - drug effects; Cell Proliferation - drug effects; Colonic Neoplasms - enzymology; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Coumaric Acids - pharmacology; DNA Topoisomerases, Type I - metabolism; Dose-Response Relationship, Drug; HCT116 Cells; Humans; Inhibitory Concentration 50; Medical sciences; Time Factors; Topoisomerase Inhibitors - pharmacology; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumors; Cell proliferation; DNA polymerase; cell cycle arrest; p53; Isomerases; Cancerology; TP53 Gene; Alkyl; Cell cycle; alkyl p-coumarates; docosyl p-coumarate; Tumor cell; Tumor suppressor gene; Human; Enzyme; Transferases; DNA topoisomerase; Enzyme inhibitor; Malignant tumor; Biological activity; anti-cancer agents; Nucleotidyltransferases; Cell death; cell growth inhibition; DNA-directed DNA polymerase; Apoptosis; Cancer

We previously found six compounds of alkyl p-coumarates from a composite plant Artemisia annua L., and chemically synthesized these compounds (cis-isomer of C20, C22 and C24, and trans-isomer of C20, C22 and C24 of p-coumarates are compounds 1-6, respectively). This report describes the inhibitory a...