Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes

• Published in: Archives of toxicology Vol. 98; no. 6; pp. 1581 - 1628
• Main Authors: Rendic, Slobodan P., Guengerich, F. Peter
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2024; Springer Nature B.V
• Subjects: Aldehyde oxidase; Aldehydes; Biomedical and Life Sciences; Biomedicine; Chemical reactions; Cytochrome P450; Cytochromes P450; Dehalogenation; Dimethylaniline monooxygenase (N-oxide-forming); Drugs; Environmental Health; Enzymes; Flavin; Metabolites; Occupational Medicine/Industrial Medicine; Peroxidase; Pharmacology/Toxicology; Review Article; Substrates; Sulfotransferase; Drugs; Toxic metabolites; Human enzymes; Toxicity impact; Reactive species

Data are presented on the formation of potentially toxic metabolites of drugs that are substrates of human drug metabolizing enzymes. The tabular data lists the formation of potentially toxic/reactive products. The data were obtained from in vitro experiments and showed that the oxidative reactions...