Single nucleotide polymorphism array (SNP-array) analysis for fetuses with abnormal nasal bone

• Published in: Archives of gynecology and obstetrics Vol. 309; no. 6; pp. 2475 - 2482
• Main Authors: Xie, Xiaorui, Su, Linjuan, Li, Ying, Shen, Qingmei, Wang, Meiying, Wu, Xiaoqing
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2024; Springer Nature B.V
• Subjects: Adult; Chromosome Aberrations - embryology; Chromosome Aberrations - statistics & numerical data; Chromosome Disorders - diagnosis; Chromosome Disorders - epidemiology; Chromosome Disorders - genetics; DNA Copy Number Variations; Down Syndrome - genetics; Endocrinology; Female; Fetuses; Gynecology; Human Genetics; Humans; Karyotyping; Maternal Age; Maternal-Fetal Medicine; Medicine; Medicine & Public Health; Nasal Bone - abnormalities; Nasal Bone - diagnostic imaging; Obstetrics/Perinatology/Midwifery; Polymorphism; Polymorphism, Single Nucleotide; Pregnancy; Prevalence; Retrospective Studies; Ultrasonic imaging; Ultrasonography, Prenatal; Nasal bone absence; Single nucleotide polymorphism array; Nasal bone hypoplasia; Copy number variations; Karyotyping

Purpose This study aims to evaluate the prevalence of submicroscopic chromosomal abnormalities found on single nucleotide polymorphism array (SNP array) in pregnancies with either an absent or hypoplastic nasal bone. Methods This retrospective study included 333 fetuses with either nasal bone hypopl...