Prevalence of osteoporosis among patients after stem cell transplantation: a systematic review and meta-analysis

The prevalence of osteoporosis in post stem cell transplantation (SCT) is poorly defined. We performed a systematic review and meta-analysis to determine the prevalence of osteoporosis in patients with hematologic diseases who underwent SCT. PubMed, EMBASE, and Web of Science were searched (from inc...

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Published in	Bone marrow transplantation (Basingstoke) Vol. 59; no. 6; pp. 785 - 794
Main Authors	Yang, Yu-Mei, Guo, Shu-Jin, Xiao, Rong, Yu, Xi-Jie, Liu, Yu-Ping, Shuai, Ping
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 01.06.2024 Nature Publishing Group
Subjects	42/100 631/532/1542 692/699/67/1990/283 Blood diseases Bone Density Bone mineral density Cell Biology Female Hematological diseases Hematology Heterogeneity Humans Internal Medicine Male Medical prognosis Medicine Medicine & Public Health Meta-analysis Osteopenia Osteoporosis Osteoporosis - diagnosis Osteoporosis - epidemiology Osteoporosis - etiology Osteoporosis - prevention & control Prevalence Public Health Stem cell transplantation Stem Cell Transplantation - adverse effects Stem Cells Subgroups Systematic review Transplantation
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ISSN	0268-3369 1476-5365 1476-5365
DOI	10.1038/s41409-024-02243-0

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Abstract	The prevalence of osteoporosis in post stem cell transplantation (SCT) is poorly defined. We performed a systematic review and meta-analysis to determine the prevalence of osteoporosis in patients with hematologic diseases who underwent SCT. PubMed, EMBASE, and Web of Science were searched (from inception to 30th April 2023) using Medical Subject Headlines to find studies that assessed the prevalence of osteoporosis among post SCT. Thirteen articles meeting the inclusion criteria were included in the analysis. The pooled prevalence rates of osteoporosis, osteopenia, and decreased bone mineral density (BMD) were determined to be 14.2% (95% CI 9.7–18.8), 36.0% (95% CI 23.8–48.2), and 47.8% (95% CI 36.6–58.9), respectively. Substantial heterogeneity was observed among the included studies (I² values ranged from 81% to 99%). Subgroup analyses revealed variations in prevalence based on gender, follow-up duration, age, region, sample size, and study quality. These findings suggest a high prevalence of osteoporosis in post-SCT patients. Given the negative impact of osteoporosis on prognosis and recipient survival, clinicians should prioritize preventive measures, early diagnosis, and effective treatments to minimize its impact.
AbstractList	The prevalence of osteoporosis in post stem cell transplantation (SCT) is poorly defined. We performed a systematic review and meta-analysis to determine the prevalence of osteoporosis in patients with hematologic diseases who underwent SCT. PubMed, EMBASE, and Web of Science were searched (from inception to 30th April 2023) using Medical Subject Headlines to find studies that assessed the prevalence of osteoporosis among post SCT. Thirteen articles meeting the inclusion criteria were included in the analysis. The pooled prevalence rates of osteoporosis, osteopenia, and decreased bone mineral density (BMD) were determined to be 14.2% (95% CI 9.7–18.8), 36.0% (95% CI 23.8–48.2), and 47.8% (95% CI 36.6–58.9), respectively. Substantial heterogeneity was observed among the included studies (I² values ranged from 81% to 99%). Subgroup analyses revealed variations in prevalence based on gender, follow-up duration, age, region, sample size, and study quality. These findings suggest a high prevalence of osteoporosis in post-SCT patients. Given the negative impact of osteoporosis on prognosis and recipient survival, clinicians should prioritize preventive measures, early diagnosis, and effective treatments to minimize its impact. The prevalence of osteoporosis in post stem cell transplantation (SCT) is poorly defined. We performed a systematic review and meta-analysis to determine the prevalence of osteoporosis in patients with hematologic diseases who underwent SCT. PubMed, EMBASE, and Web of Science were searched (from inception to 30th April 2023) using Medical Subject Headlines to find studies that assessed the prevalence of osteoporosis among post SCT. Thirteen articles meeting the inclusion criteria were included in the analysis. The pooled prevalence rates of osteoporosis, osteopenia, and decreased bone mineral density (BMD) were determined to be 14.2% (95% CI 9.7-18.8), 36.0% (95% CI 23.8-48.2), and 47.8% (95% CI 36.6-58.9), respectively. Substantial heterogeneity was observed among the included studies (I² values ranged from 81% to 99%). Subgroup analyses revealed variations in prevalence based on gender, follow-up duration, age, region, sample size, and study quality. These findings suggest a high prevalence of osteoporosis in post-SCT patients. Given the negative impact of osteoporosis on prognosis and recipient survival, clinicians should prioritize preventive measures, early diagnosis, and effective treatments to minimize its impact.The prevalence of osteoporosis in post stem cell transplantation (SCT) is poorly defined. We performed a systematic review and meta-analysis to determine the prevalence of osteoporosis in patients with hematologic diseases who underwent SCT. PubMed, EMBASE, and Web of Science were searched (from inception to 30th April 2023) using Medical Subject Headlines to find studies that assessed the prevalence of osteoporosis among post SCT. Thirteen articles meeting the inclusion criteria were included in the analysis. The pooled prevalence rates of osteoporosis, osteopenia, and decreased bone mineral density (BMD) were determined to be 14.2% (95% CI 9.7-18.8), 36.0% (95% CI 23.8-48.2), and 47.8% (95% CI 36.6-58.9), respectively. Substantial heterogeneity was observed among the included studies (I² values ranged from 81% to 99%). Subgroup analyses revealed variations in prevalence based on gender, follow-up duration, age, region, sample size, and study quality. These findings suggest a high prevalence of osteoporosis in post-SCT patients. Given the negative impact of osteoporosis on prognosis and recipient survival, clinicians should prioritize preventive measures, early diagnosis, and effective treatments to minimize its impact.
Author	Liu, Yu-Ping Guo, Shu-Jin Yu, Xi-Jie Xiao, Rong Yang, Yu-Mei Shuai, Ping
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Snippet	The prevalence of osteoporosis in post stem cell transplantation (SCT) is poorly defined. We performed a systematic review and meta-analysis to determine the...
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SubjectTerms	42/100 631/532/1542 692/699/67/1990/283 Blood diseases Bone Density Bone mineral density Cell Biology Female Hematological diseases Hematology Heterogeneity Humans Internal Medicine Male Medical prognosis Medicine Medicine & Public Health Meta-analysis Osteopenia Osteoporosis Osteoporosis - diagnosis Osteoporosis - epidemiology Osteoporosis - etiology Osteoporosis - prevention & control Prevalence Public Health Stem cell transplantation Stem Cell Transplantation - adverse effects Stem Cells Subgroups Systematic review Transplantation
Title	Prevalence of osteoporosis among patients after stem cell transplantation: a systematic review and meta-analysis
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