A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans
We have developed an Escherichia coli strain for the in vivo production of O-glycosylated proteins. This was achieved using a dual plasmid approach: one encoding a therapeutic protein target, and a second encoding the enzymatic machinery required for O-glycosylation. The latter plasmid encodes human...
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Published in | Cell chemical biology Vol. 26; no. 2; pp. 203 - 212.e5 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
21.02.2019
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Subjects | |
Online Access | Get full text |
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