Janus Kinase Inhibitor Brepocitinib Rescues Myelin Phagocytosis Under Inflammatory Conditions: In Vitro Evidence from Microglia and Macrophage Cell Lines

• Published in: Molecular neurobiology Vol. 61; no. 9; pp. 6423 - 6434
• Main Authors: Romero-Ramírez, Lorenzo, García-Rama, Concepción, Mey, Jörg
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2024; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell culture; Cell death; Cell lines; Central nervous system; Cytokines; Genes; Inflammation; Injuries; Janus kinase; Kinases; Lipids; Lipopolysaccharides; Lysosomes; Macrophages; Microglia; Myelin; Myeloid cells; Neurobiology; Neurology; Neurosciences; Neutrophils; Phagocytosis; Phosphorylation; Reagents; Stat3 protein; Transcription factors; γ-Interferon; IFNγ; Janus kinases; Brepocitinib; Myelin phagocytosis; Macrophages; LPS

Central nervous system (CNS) injuries induce cell death and consequently the release of myelin and other cellular debris. Microglia as well as hematogenous macrophages actively collaborate to phagocyte them and undergo their degradation. However, myelin accumulation persists in the lesion site long...