Foxg1 Overexpression in Neocortical Pyramids Stimulates Dendrite Elongation Via Hes1 and pCreb1 Upregulation

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 29; no. 3; pp. 1006 - 1019
• Main Authors: Chiola, Simone, Do, Mihn Duc, Centrone, Lucy, Mallamaci, Antonello
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.03.2019
• Subjects: Animals; Cells, Cultured; Cyclic AMP Response Element-Binding Protein - metabolism; Dendrites - metabolism; Down-Regulation; Female; Forkhead Transcription Factors - metabolism; Gene Expression Regulation; Male; Mice; Neocortex - metabolism; Nerve Tissue Proteins - metabolism; Phosphorylation; Pyramidal Cells - metabolism; Signal Transduction; Transcription Factor HES-1 - metabolism; Up-Regulation; West syndrome; dendrite; Rett syndrome

Abstract The architecture of neocortical projection neurons is subject of a complex gene control. Here we demonstrated that Foxg1, a transcription factor gene which patterns the early rostral brain and sets the pace of telencephalic neuronogenesis, specifically stimulates dendrite elongation. This p...