NFKB1 -94 insertion/deletion ATTG polymorphism contributes to risk of systemic lupus erythematosus

• Published in: DNA and cell biology Vol. 31; no. 4; p. 611
• Main Authors: Gao, Ming, Wang, Chun-Hui, Sima, Xiutian, Han, Xue-Mei
• Format: Journal Article
• Language: English
• Published: United States 01.04.2012
• Subjects: Asian Continental Ancestry Group - genetics; Case-Control Studies; China - epidemiology; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genotype; Humans; INDEL Mutation - genetics; Lupus Erythematosus, Systemic - epidemiology; Lupus Erythematosus, Systemic - genetics; NF-kappa B p50 Subunit - genetics; Polymerase Chain Reaction; Polymorphism, Genetic - genetics; Promoter Regions, Genetic - genetics; Risk Factors; Sequence Analysis, DNA; China
• ISSN: 1557-7430
• DOI: 10.1089/dna.2011.1389

Growing evidence has shown that nuclear factor-κB (NF-κB) plays a key role in the initiation and progression of systemic lupus erythematosus (SLE) pathogenesis. A common polymorphism (-94 insertion/deletion ATTG, rs28362491) in the promoter region of NFKB1 gene was identified as functional. The -94d...