Zinc finger BED-type containing 3 promotes hepatic steatosis by interacting with polypyrimidine tract-binding protein 1

• Published in: Diabetologia Vol. 67; no. 10; pp. 2346 - 2366
• Main Authors: Wu, Yao, Yang, Min, Wu, Shao-bo, Luo, Pei-qi, Zhang, Cheng, Ruan, Chang-shun, Cui, Wei, Zhao, Qiu-rong, Chen, Lin-xin, Meng, Juan-juan, Song, Qiang, Zhang, Wen-jin, Pei, Qin-qin, Li, Fang, Zeng, Ting, Du, Hong-xin, Xu, Li-xin, Zhang, Weizhen, Zhang, Xian-xiang, Luo, Xiao-he
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2024; Springer Nature B.V
• Subjects: Alternative splicing; Animal models; Animals; Bioinformatics; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - metabolism; Diet, High-Fat; Fatty liver; Fatty Liver - metabolism; Gene expression; Hepatocytes; High fat diet; Human Physiology; Humans; Immunoprecipitation; Insulin resistance; Insulin Resistance - physiology; Internal Medicine; Liver - metabolism; Liver diseases; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic syndrome; Metabolic Syndrome - metabolism; Mice; Mice, Inbred C57BL; Molecular modelling; mRNA stability; Polypyrimidine tract-binding protein; Polypyrimidine Tract-Binding Protein - genetics; Polypyrimidine Tract-Binding Protein - metabolism; Proteins; Proteomics; RNA viruses; Steatosis; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Sterol regulatory element-binding protein; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptomes; Zinc finger proteins; SREBP1c; Alternative splicing; PTBP1; MASLD; ZBED3

Aims/hypothesis The relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes mellitus, insulin resistance and the metabolic syndrome is well established. While zinc finger BED-type containing 3 (ZBED3) has been linked to type 2 diabetes mellitus and t...