AACC Guidance Document on Biotin Interference in Laboratory Tests

• Published in: The journal of applied laboratory medicine Vol. 5; no. 3; p. 575
• Main Authors: Li, Danni, Ferguson, Angela, Cervinski, Mark A, Lynch, Kara L, Kyle, Patrick B
• Format: Journal Article
• Language: English
• Published: England 01.05.2020
• Subjects: Biotin Interference; Biotin; Immunoassay Interference

Laboratory tests that use streptavidin-biotin binding mechanisms have the potential to be affected by high circulating biotin concentrations, which would produce positive and negative interference in biotinylated competitive and noncompetitive (sandwich) immunoassays, respectively. Consumption of hi...