Anti-ageing antibodies revive the immune system

Depleting an expanding pool of aberrant stem cells in aged mice using antibody therapy has been shown to rebalance blood cell production, diminish age-associated inflammation and strengthen acquired immune responses. Rejuvenating an aged immune system with antibody therapy.

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Published inNature (London) Vol. 628; no. 8006; pp. 43 - 45
Main Authors Kasu, Yasar Arfat T., Signer, Robert A. J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 04.04.2024
Nature Publishing Group
Subjects
631/136/7
631/250
692/700/565
Adaptive immunity
Age
Aging
Antibodies
Blood
Blood cells
Cancer
Chronic illnesses
Depletion
Genes
Humanities and Social Sciences
Immune System
Infections
Inflammation
Inflammatory diseases
Lymphocytes
multidisciplinary
News And Views
Older people
Proteins
Regenerative medicine
Science
Stem cells
Transcription activation
United States > US
California
Ageing
Immunology
Therapeutics
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Abstract Depleting an expanding pool of aberrant stem cells in aged mice using antibody therapy has been shown to rebalance blood cell production, diminish age-associated inflammation and strengthen acquired immune responses. Rejuvenating an aged immune system with antibody therapy.
AbstractList Depleting an expanding pool of aberrant stem cells in aged mice using antibody therapy has been shown to rebalance blood cell production, diminish age-associated inflammation and strengthen acquired immune responses. Rejuvenating an aged immune system with antibody therapy.
In addition to partially rebalancing blood cell production and restoring adaptive immunity, depleting myeloid-biased HSCs in aged mice reduced the abundance of several inflammation-mediating molecules that circulate in the blood. [...]this approach has the potential to attenuate Inflammageing' and reduce the incidence and severity of diverse age-related inflammatory diseases. Depletion of myeloid-biased HSCs could force a compensatory expansion of the remaining HSC pool and confer a selective pressure on residual HSCs harbouring advantageous mutations; ultimately, this could accelerate clonal dominance and progression to cancer. Lymphoid leukaemias are the most common form of cancer in children, and age-related activation of tumour-suppressor genes in lymphoid progenitors helps to prevent these cells from becoming cancerous in adulthood, but this occurs at the expense of maintaining robust lymphopoiesis11. Yasar Arfai T. Kasu and Robert A. J. Signer are in the Division of Regenerative Medicine, Department of Medicine, Stem Cell Discovery Center, Sanford Stem Cell Institute, Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA. e-mail: rsigner@health.ucsd.edu The authors declare no competing interests.
Author Signer, Robert A. J.
Kasu, Yasar Arfat T.
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Snippet Depleting an expanding pool of aberrant stem cells in aged mice using antibody therapy has been shown to rebalance blood cell production, diminish...
In addition to partially rebalancing blood cell production and restoring adaptive immunity, depleting myeloid-biased HSCs in aged mice reduced the abundance of...
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SubjectTerms 631/136/7
631/250
692/700/565
Adaptive immunity
Age
Aging
Antibodies
Blood
Blood cells
Cancer
Chronic illnesses
Depletion
Genes
Humanities and Social Sciences
Immune System
Infections
Inflammation
Inflammatory diseases
Lymphocytes
multidisciplinary
News And Views
Older people
Proteins
Regenerative medicine
Science
Stem cells
Transcription activation
Title Anti-ageing antibodies revive the immune system
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