[123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials

• Published in: European archives of psychiatry and clinical neuroscience Vol. 258; no. 1; pp. 40 - 47
• Main Authors: Pogarell, Oliver, Koch, Walter, Schaaff, Nadine, Pöpperl, Gabriele, Mulert, Christoph, Juckel, Georg, Möller, Hans-Jürgen, Hegerl, Ulrich, Tatsch, Klaus
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.12.2007
• Subjects: Acoustic Stimulation; Adult; Brain Stem - diagnostic imaging; Brain Stem - metabolism; Cinanserin - analogs & derivatives; Evoked Potentials, Auditory, Brain Stem - physiology; Female; Humans; Image Processing, Computer-Assisted; Male; Radiopharmaceuticals; Serotonin - metabolism; Serotonin - physiology; Tomography, Emission-Computed, Single-Photon

The in vivo assessment of brain serotonergic function might be of clinical relevance in neuropsychiatry. The loudness dependence of auditory evoked potentials (LD) has been proposed as an indirect indicator of cortical serotonergic activity, whereas single photon emission computed tomography (SPECT)...