Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia model

• Published in: Pharmacology, biochemistry and behavior Vol. 78; no. 2; pp. 349 - 355
• Main Authors: Wallace, Mark S, Quessy, Steve, Schulteis, Gery
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.06.2004
• Subjects: Antagonists; Capsaicin; Channel; Experimental; Pain; Sodium; Antagonists; Pain; Sodium; Capsaicin; Experimental; Channel

Preclinical studies have emphasized that persistent small afferent input will induce a state of central facilitation, which can be regulated by systemically administered sodium channel blockers. We have extended these preclinical studies to the human volunteers by examining the effects of lamotrigin...