Combating antimicrobial resistance in malaria, HIV and tuberculosis

Antimicrobial resistance poses a significant threat to the sustainability of effective treatments against the three most prevalent infectious diseases: malaria, human immunodeficiency virus (HIV) infection and tuberculosis. Therefore, there is an urgent need to develop novel drugs and treatment prot...

Full description

Saved in:
Bibliographic Details
Published inNature reviews. Drug discovery Vol. 23; no. 6; pp. 461 - 479
Main Authors Duffey, Maëlle, Shafer, Robert W., Timm, Juliano, Burrows, Jeremy N., Fotouhi, Nader, Cockett, Mark, Leroy, Didier
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.06.2024
Nature Publishing Group
Subjects
631/154
692/699/255
Antimicrobial agents
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cancer Research
Drug development
Drug resistance
HIV
Human immunodeficiency virus
Immune system
Infectious diseases
Malaria
Medicinal Chemistry
Molecular Medicine
Pharmacology/Toxicology
Review Article
Tuberculosis
Online AccessGet full text

Cover

Abstract Antimicrobial resistance poses a significant threat to the sustainability of effective treatments against the three most prevalent infectious diseases: malaria, human immunodeficiency virus (HIV) infection and tuberculosis. Therefore, there is an urgent need to develop novel drugs and treatment protocols capable of reducing the emergence of resistance and combating it when it does occur. In this Review, we present an overview of the status and underlying molecular mechanisms of drug resistance in these three diseases. We also discuss current strategies to address resistance during the research and development of next-generation therapies. These strategies vary depending on the infectious agent and the array of resistance mechanisms involved. Furthermore, we explore the potential for cross-fertilization of knowledge and technology among these diseases to create innovative approaches for minimizing drug resistance and advancing the discovery and development of new anti-infective treatments. In conclusion, we advocate for the implementation of well-defined strategies to effectively mitigate and manage resistance in all interventions against infectious diseases.  The rise of drug resistance presents a significant challenge in the treatment of infectious diseases. This Review summarizes the status and mechanisms of drug resistance in malaria, human immunodeficiency virus (HIV) infection and tuberculosis, and explores strategies to address resistance that could be incorporated into drug development across these disease areas.
AbstractList Antimicrobial resistance poses a significant threat to the sustainability of effective treatments against the three most prevalent infectious diseases: malaria, human immunodeficiency virus (HIV) infection and tuberculosis. Therefore, there is an urgent need to develop novel drugs and treatment protocols capable of reducing the emergence of resistance and combating it when it does occur. In this Review, we present an overview of the status and underlying molecular mechanisms of drug resistance in these three diseases. We also discuss current strategies to address resistance during the research and development of next-generation therapies. These strategies vary depending on the infectious agent and the array of resistance mechanisms involved. Furthermore, we explore the potential for cross-fertilization of knowledge and technology among these diseases to create innovative approaches for minimizing drug resistance and advancing the discovery and development of new anti-infective treatments. In conclusion, we advocate for the implementation of well-defined strategies to effectively mitigate and manage resistance in all interventions against infectious diseases.  The rise of drug resistance presents a significant challenge in the treatment of infectious diseases. This Review summarizes the status and mechanisms of drug resistance in malaria, human immunodeficiency virus (HIV) infection and tuberculosis, and explores strategies to address resistance that could be incorporated into drug development across these disease areas.
Antimicrobial resistance poses a significant threat to the sustainability of effective treatments against the three most prevalent infectious diseases: malaria, human immunodeficiency virus (HIV) infection and tuberculosis. Therefore, there is an urgent need to develop novel drugs and treatment protocols capable of reducing the emergence of resistance and combating it when it does occur. In this Review, we present an overview of the status and underlying molecular mechanisms of drug resistance in these three diseases. We also discuss current strategies to address resistance during the research and development of next-generation therapies. These strategies vary depending on the infectious agent and the array of resistance mechanisms involved. Furthermore, we explore the potential for cross-fertilization of knowledge and technology among these diseases to create innovative approaches for minimizing drug resistance and advancing the discovery and development of new anti-infective treatments. In conclusion, we advocate for the implementation of well-defined strategies to effectively mitigate and manage resistance in all interventions against infectious diseases.
Antimicrobial resistance poses a significant threat to the sustainability of effective treatments against the three most prevalent infectious diseases: malaria, human immunodeficiency virus (HIV) infection and tuberculosis. Therefore, there is an urgent need to develop novel drugs and treatment protocols capable of reducing the emergence of resistance and combating it when it does occur. In this Review, we present an overview of the status and underlying molecular mechanisms of drug resistance in these three diseases. We also discuss current strategies to address resistance during the research and development of next-generation therapies. These strategies vary depending on the infectious agent and the array of resistance mechanisms involved. Furthermore, we explore the potential for cross-fertilization of knowledge and technology among these diseases to create innovative approaches for minimizing drug resistance and advancing the discovery and development of new anti-infective treatments. In conclusion, we advocate for the implementation of well-defined strategies to effectively mitigate and manage resistance in all interventions against infectious diseases.Antimicrobial resistance poses a significant threat to the sustainability of effective treatments against the three most prevalent infectious diseases: malaria, human immunodeficiency virus (HIV) infection and tuberculosis. Therefore, there is an urgent need to develop novel drugs and treatment protocols capable of reducing the emergence of resistance and combating it when it does occur. In this Review, we present an overview of the status and underlying molecular mechanisms of drug resistance in these three diseases. We also discuss current strategies to address resistance during the research and development of next-generation therapies. These strategies vary depending on the infectious agent and the array of resistance mechanisms involved. Furthermore, we explore the potential for cross-fertilization of knowledge and technology among these diseases to create innovative approaches for minimizing drug resistance and advancing the discovery and development of new anti-infective treatments. In conclusion, we advocate for the implementation of well-defined strategies to effectively mitigate and manage resistance in all interventions against infectious diseases.
Antimicrobial resistance poses a significant threat to the sustainability of effective treatments against the three most prevalent infectious diseases: malaria, human immunodeficiency virus (HIV) infection and tuberculosis. Therefore, there is an urgent need to develop novel drugs and treatment protocols capable of reducing the emergence of resistance and combating it when it does occur. In this Review, we present an overview of the status and underlying molecular mechanisms of drug resistance in these three diseases. We also discuss current strategies to address resistance during the research and development of next-generation therapies. These strategies vary depending on the infectious agent and the array of resistance mechanisms involved. Furthermore, we explore the potential for cross-fertilization of knowledge and technology among these diseases to create innovative approaches for minimizing drug resistance and advancing the discovery and development of new anti-infective treatments. In conclusion, we advocate for the implementation of well-defined strategies to effectively mitigate and manage resistance in all interventions against infectious diseases. The rise of drug resistance presents a significant challenge in the treatment of infectious diseases. This Review summarizes the status and mechanisms of drug resistance in malaria, human immunodeficiency virus (HIV) infection and tuberculosis, and explores strategies to address resistance that could be incorporated into drug development across these disease areas.
Author Timm, Juliano
Burrows, Jeremy N.
Leroy, Didier
Fotouhi, Nader
Shafer, Robert W.
Cockett, Mark
Duffey, Maëlle
Author_xml – sequence: 1
  givenname: Maëlle
  orcidid: 0000-0002-4319-0647
  surname: Duffey
  fullname: Duffey, Maëlle
  organization: Medicines for Malaria Venture (MMV), R&D Department/Drug Discovery, ICC, The Global Antibiotic Research & Development Partnership
– sequence: 2
  givenname: Robert W.
  orcidid: 0000-0003-2513-2643
  surname: Shafer
  fullname: Shafer, Robert W.
  organization: Department of Medicine/Infectious Diseases, Stanford University
– sequence: 3
  givenname: Juliano
  surname: Timm
  fullname: Timm, Juliano
  organization: TB Alliance
– sequence: 4
  givenname: Jeremy N.
  orcidid: 0000-0001-8448-6068
  surname: Burrows
  fullname: Burrows, Jeremy N.
  organization: Medicines for Malaria Venture (MMV), R&D Department/Drug Discovery, ICC
– sequence: 5
  givenname: Nader
  surname: Fotouhi
  fullname: Fotouhi, Nader
  organization: TB Alliance
– sequence: 6
  givenname: Mark
  orcidid: 0000-0002-9423-7548
  surname: Cockett
  fullname: Cockett, Mark
  organization: Alphina Therapeutics
– sequence: 7
  givenname: Didier
  orcidid: 0000-0002-5594-3204
  surname: Leroy
  fullname: Leroy, Didier
  email: leroyd@mmv.org
  organization: Medicines for Malaria Venture (MMV), R&D Department/Drug Discovery, ICC
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38750260$$D View this record in MEDLINE/PubMed
BookMark eNp9kD1PwzAQhi0Eoh_wBxhQJBYGAv6KnYwoAlqpEguwWo5zqVwlTrGTgX-PoaVIDEw-yc-9d_fM0LHrHSB0QfAtwSy_C5xkkqWY8hTjgrGUH6Ep4ZKnROb8-FBLMUGzEDYYE0EkPUUTlssMU4GnqCz7rtKDdetEu8F21vi-srpNPAQbBu0MJNYlnW61t_omWSzfIlgnw1iBN2PbR-oMnTS6DXC-f-fo9fHhpVykq-enZXm_Sg2jYkhlTaQhhOeQFXWdVQaMgUZozCnIjPC4jxDxkKyGvGg4MaaimOu6ajiwIgc2R9e73K3v30cIg-psMNC22kE_BsVwluUFp1HKHF39QTf96F3cLlKCS0ELWUSK7qh4dAgeGrX1ttP-QxGsvhSrnWIVFatvxYrHpst99Fh1UB9afpxGgO2AEL_cGvzv7H9iPwFalId6
Cites_doi 10.1371/journal.pone.0239333
10.3390/electronics11172634
10.1128/AAC.02104-18
10.1111/bcp.12403
10.1056/NEJMc1505196
10.1093/jac/dkz417
10.1038/nrmicro1529
10.1093/infdis/jiaa625
10.1097/QAI.0000000000002850
10.1016/j.pt.2021.04.006
10.1016/S1473-3099(19)30543-2
10.1016/S0140-6736(04)16767-6
10.1016/j.chembiol.2013.07.014
10.1371/journal.ppat.1009671
10.1371/journal.pgph.0002283
10.1038/s41579-022-00731-y
10.1016/S2666-5247(22)00155-0
10.1038/s41598-023-27516-4
10.3389/fphar.2015.00090
10.1016/j.cell.2021.06.033
10.1001/jama.300.4.423
10.1126/science.8284673
10.1136/bmjopen-2020-040220
10.1016/j.tips.2017.03.007
10.1073/pnas.0804628105
10.1186/s12977-017-0360-7
10.1016/S0140-6736(22)00538-4
10.1038/s41591-021-01590-5
10.1128/AAC.00308-15
10.1073/pnas.1813386115
10.1093/cid/ciab583
10.1128/jvi.69.8.5087-5094.1995
10.1038/ncomms11901
10.15585/mmwr.mm7108a1
10.1056/NEJMoa2119430
10.1111/tmi.12297
10.3390/chemistry4020019
10.1371/journal.pbio.3001721
10.1056/NEJMoa2033400
10.3390/v13050735
10.1016/S0140-6736(20)30552-3
10.3390/v2020606
10.1111/j.1574-6968.1996.tb08515.x
10.1126/science.1106753
10.1089/aid.2019.0171
10.1186/s13073-021-00953-4
10.1186/s12936-015-0550-5
10.1038/s41598-022-06449-4
10.1038/s41586-020-2443-1
10.1186/s12859-019-2991-2
10.1086/427782
10.1378/chest.08-2427
10.1056/NEJMoa2101016
10.1056/NEJM200101253440403
10.1097/COH.0000000000000591
10.1038/nature12876
10.1021/jm030558s
10.1016/S0140-6736(12)60085-3
10.1186/1742-4690-9-63
10.1016/j.cell.2021.01.025
10.1016/j.jconrel.2015.08.018
10.1186/s12977-020-00516-2
10.1093/jac/dkt358
10.1186/s12936-019-2724-z
10.1111/febs.14127
10.1056/NEJMoa1909512
10.1016/S2666-5247(20)30006-9
10.1016/S0140-6736(10)60483-7
10.1038/s41467-022-33873-x
10.1128/AAC.00835-15
10.1086/378281
10.1016/S2352-3018(18)30094-8
10.1016/j.medj.2021.11.005
10.1021/acsinfecdis.0c00724
10.1056/NEJMoa2115542
10.1128/AAC.00112-06
10.1186/s12879-022-07067-1
10.1016/j.ijpddr.2018.11.004
10.1016/S2352-3018(16)30091-1
10.1101/cshperspect.a006924
10.1016/S2666-5247(21)00301-3
10.1002/jia2.25611
10.1371/journal.pone.0267159
10.1186/1741-7007-11-96
10.1016/j.celrep.2016.06.026
10.1177/1178636118808529
10.1016/j.eng.2018.11.011
10.1128/AAC.00566-11
10.1038/s41467-023-37184-7
10.7554/eLife.85023
10.1016/S0140-6736(22)01881-5
10.1093/jac/dkab505
10.1073/pnas.1204556109
10.1128/AAC.47.12.3799-3805.2003
10.1016/S1473-3099(21)00252-8
10.1016/S1473-3099(19)30391-3
10.1073/pnas.1320886110
10.3389/fgene.2019.00922
10.1093/infdis/jiaa683
10.1016/S2352-3018(23)00051-6
10.1073/pnas.87.8.3018
10.1016/j.pt.2020.09.011
10.1371/journal.pntd.0005480
10.5588/ijtld.15.0389
10.1371/journal.pmed.1001984
10.1016/j.virusres.2007.12.015
10.1016/j.drudis.2020.10.010
10.1097/COH.0000000000000743
10.1186/s12916-017-0834-4
10.1016/S1473-3099(15)00536-8
10.1128/JVI.00495-16
10.1016/S0140-6736(18)32462-0
10.1073/pnas.85.23.9109
10.7554/eLife.69032
10.1038/sj.emboj.7600681
10.1073/pnas.0508392103
10.1128/AAC.01876-21
10.1056/NEJMoa2101746
10.1038/s41467-021-21187-3
10.1126/science.aar4189
10.3201/eid2703.204418
10.1111/hiv.13095
10.1016/j.bmc.2016.07.039
10.1097/QAD.0000000000000494
10.1021/acs.jmedchem.7b01337
10.1001/archinte.167.4.335
10.1016/S1473-3099(21)00692-7
10.1126/science.7824947
10.1128/mBio.01586-16
10.1038/ng.2517
10.1016/j.xcrm.2021.100423
10.1111/j.1365-2958.1995.tb02238.x
10.1111/imr.12951
10.1073/pnas.94.4.1124
10.1371/journal.pmed.1002595
10.1093/infdis/jiaa498
10.1038/s41467-023-36921-2
10.3389/fimmu.2021.816515
10.1371/journal.pmed.1002152
10.3389/fphar.2022.876282
10.1126/science.aan4472
10.1016/S0140-6736(19)30308-3
10.1038/s41385-019-0226-5
10.1056/NEJMoa0808859
10.1038/nm0696-662
10.1016/S0140-6736(20)32666-0
10.1038/nm.4381
10.1073/pnas.0902437106
10.1073/pnas.1820333116
10.1126/science.1124410
10.1084/jem.20210724
10.1093/cid/ciab160
10.1186/s13071-022-05422-4
10.1038/s41467-018-04217-5
10.1128/AAC.01584-21
10.3389/fmicb.2015.00517
10.1038/nrmicro2331
10.1038/s41564-020-0735-8
10.1038/nrd.2016.160
10.1093/jac/dkw463
10.1016/S1473-3099(21)00470-9
10.1016/S1473-3099(09)70136-7
10.1128/AAC.47.8.2418-2423.2003
10.1371/journal.pdig.0000059
10.1038/s41467-023-37719-y
10.1021/acsmedchemlett.2c00115
10.1128/AAC.46.3.909-912.2002
10.1128/AAC.41.8.1677
10.1093/femsre/fux011
10.1126/scitranslmed.3006609
10.1016/0166-6851(92)90047-N
10.1016/j.tim.2019.06.002
10.1086/375599
10.1016/S1473-3099(16)30415-7
10.1001/jama.2022.22246
10.1093/cid/ciab716
10.1111/j.1432-1033.1994.00397.x
10.1016/S1473-3099(18)30309-8
10.1097/COH.0000000000000735
10.1016/S0166-3542(99)00010-8
10.5588/ijtld.21.0515
10.1126/science.1074045
10.1128/JVI.00915-10
10.1056/NEJMoa2203067
10.1073/pnas.91.15.7149
10.1093/infdis/jit077
10.1371/journal.pone.0154166
10.1016/j.puhe.2020.07.031
10.1038/s41467-018-05652-0
10.1038/ng.1038
10.1128/AAC.00037-14
ContentType Journal Article
Copyright Springer Nature Limited 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
2024. Springer Nature Limited.
Copyright_xml – notice: Springer Nature Limited 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
– notice: 2024. Springer Nature Limited.
DBID NPM
AAYXX
CITATION
K9.
NAPCQ
7X8
DOI 10.1038/s41573-024-00933-4
DatabaseName PubMed
CrossRef
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
MEDLINE - Academic
DatabaseTitleList
PubMed
MEDLINE - Academic
ProQuest Health & Medical Complete (Alumni)
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1474-1784
EndPage 479
ExternalDocumentID 10_1038_s41573_024_00933_4
38750260
Genre Journal Article
Review
GroupedDBID ---
0R~
123
29M
36B
39C
3V.
4.4
53G
70F
7RV
7X7
88E
8AO
8FI
8FJ
8R4
8R5
AAEEF
AARCD
AAWYQ
AAYOK
AAZLF
ABAWZ
ABDBF
ABJNI
ABLJU
ABUWG
ABVXF
ACGFO
ACGFS
ACMJI
ADBBV
ADFRT
AENEX
AFBBN
AFKRA
AFSHS
AGAYW
AGEZK
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
AIYXT
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
B0M
BENPR
BKEYQ
BKKNO
BPHCQ
BVXVI
CCPQU
CS3
DB5
DU5
EAD
EAP
EBS
EE.
EJD
EMB
EMK
EMOBN
EPL
ESX
EX3
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
HMCUK
HVGLF
HZ~
IAO
IHR
INH
INR
ITC
L-9
LGEZI
LOTEE
M1P
MK0
N9A
NADUK
NAPCQ
NNMJJ
NXXTH
O9-
ODYON
P2P
PQQKQ
PROAC
PSQYO
Q2X
RNR
RNS
RNT
RNTTT
SHXYY
SIXXV
SNYQT
SV3
TAOOD
TBHMF
TDRGL
TSG
TUS
UKHRP
WOW
~8M
AAYZH
NPM
AAYXX
CITATION
K9.
7X8
ID FETCH-LOGICAL-c326t-7d17c1148e59dd5bceccef6a042e7514260660095de89f41ccb204adbf4e398e3
ISSN 1474-1776
1474-1784
IngestDate Sat Oct 26 04:39:53 EDT 2024
Wed Nov 06 08:01:06 EST 2024
Thu Nov 21 21:12:27 EST 2024
Sat Nov 02 12:20:21 EDT 2024
Fri Oct 11 20:49:03 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
License 2024. Springer Nature Limited.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c326t-7d17c1148e59dd5bceccef6a042e7514260660095de89f41ccb204adbf4e398e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0001-8448-6068
0000-0002-4319-0647
0000-0002-9423-7548
0000-0003-2513-2643
0000-0002-5594-3204
PMID 38750260
PQID 3064762979
PQPubID 27580
PageCount 19
ParticipantIDs proquest_miscellaneous_3055894257
proquest_journals_3064762979
crossref_primary_10_1038_s41573_024_00933_4
pubmed_primary_38750260
springer_journals_10_1038_s41573_024_00933_4
PublicationCentury 2000
PublicationDate 2024-06-01
PublicationDateYYYYMMDD 2024-06-01
PublicationDate_xml – month: 06
  year: 2024
  text: 2024-06-01
  day: 01
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature reviews. Drug discovery
PublicationTitleAbbrev Nat Rev Drug Discov
PublicationTitleAlternate Nat Rev Drug Discov
PublicationYear 2024
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References PerelsonASRibeiroRMModeling the within-host dynamics of HIV infectionBMC Biol.20131124020860376593910.1186/1741-7007-11-96
FederAFHarperKNBrummeCJPenningsPSUnderstanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneityeLife2021101:CAS:528:DC%2BB38XltlGmsrk%3D34473060841292110.7554/eLife.69032This work analyses the evolution of HIV drug resistance from a spatial-temporal perspective during long-term drug treatment.
DjimdéAA molecular marker for chloroquine-resistant falciparum malariaN. Engl. J. Med.20013442572631117215210.1056/NEJM200101253440403This pivotal study on drug resistance in malaria demonstrates that thepfcrtT76 mutation inP. falciparumis associated with clinical resistance to chloroquine, suggesting that this mutation can be used as a marker in surveillance for chloroquine-resistantP. falciparummalaria.
World Health Organization. Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection (WHO, 2016).
DickerIGSK3640254 is a novel HIV-1 maturation inhibitor with an optimized virology profileAntimicrob. Agents Chemother.202266e01876e019211:CAS:528:DC%2BB38XjtFKksbs%3D34780263876543710.1128/AAC.01876-21
HuangLSMSnyderEYSchooleyRTStrategies and progress in CXCR4-targeted anti-human immunodeficiency virus (HIV) therapeutic developmentClin. Infect. Dis.2021739199241:CAS:528:DC%2BB3MXitFGgsbfF3362402710.1093/cid/ciab160
BoereeMJUNITE4TB: a new consortium for clinical drug and regimen development for TBInt. J. Tuberc. Lung Dis.2021258868891:STN:280:DC%2BB2cjjvFSkug%3D%3D34686229854492210.5588/ijtld.21.0515
VelayatiAAEmergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in IranChest20091364204251934938010.1378/chest.08-2427
BatesMNRisk of tuberculosis from exposure to tobacco smoke: a systematic review and meta-analysisArch. Intern. Med.20071673353421732529410.1001/archinte.167.4.335
Timm IdJBaseline and acquired resistance to bedaquiline, linezolid and pretomanid, and impact on treatment outcomes in four tuberculosis clinical trials containing pretomanidPLOS Glob. Public. Health2023310.1371/journal.pgph.0002283
AbramMEFerrisALShaoWAlvordWGHughesSHNature, position, and frequency of mutations made in a single cycle of HIV-1 replicationJ. Virol.201084986498781:CAS:528:DC%2BC3cXhtlarsrnL20660205293779910.1128/JVI.00915-10
World Health Organization. WHO Guidelines for Malaria 2022 (WHO, 2022).
ScorpioAZhangYMutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillusNat. Med.199626626671:CAS:528:DyaK28XjsVSjtbo%3D864055710.1038/nm0696-662
OboreNKawukiJGuanJPapabathiniSSWangLAssociation between indoor air pollution, tobacco smoke and tuberculosis: an updated systematic review and meta-analysisPublic. Health202018724351:STN:280:DC%2BB38bkvVSksQ%3D%3D3288922910.1016/j.puhe.2020.07.031
GottliebGSRaugiDNSmithRA90–90–90 for HIV-2? Ending the HIV-2 epidemic by enhancing care and clinical management of patients infected with HIV-2Lancet HIV20185e390e3993005250910.1016/S2352-3018(18)30094-8
LeangREvidence of Plasmodium falciparum malaria multidrug resistance to artemisinin and piperaquine in western Cambodia: dihydroartemisinin–piperaquine open-label multicenter clinical assessmentAntimicrob. Agents Chemother.201559471947261:CAS:528:DC%2BC2MXht1KntLzF26014949450519310.1128/AAC.00835-15
LoiseauCThe relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspotNat. Commun.20231411110.1038/s41467-023-37719-yThis work demonstrates that the transmission fitness of resistant TB strains can be as high as that of drug-sensitive pathogens.
GuptaRKVirological monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysisLancet Infect. Dis.200994094171:CAS:528:DC%2BD1MXovV2hsbo%3D1955590010.1016/S1473-3099(09)70136-7
CowellANMapping the malaria parasite druggable genome by using in vitro evolution and chemogenomicsScience20183591911991:CAS:528:DC%2BC1cXmt1ehug%3D%3D29326268592575610.1126/science.aan4472
PetoTJTriple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trialLancet Infect. Dis.2022228678781:CAS:528:DC%2BB38Xhtlant7fM35276064913277710.1016/S1473-3099(21)00692-7
World Health Organization. World Malaria Report 2021 (WHO, 2021).
PhamQDWilsonDPLawMGKelleherADZhangLGlobal burden of transmitted HIV drug resistance and HIV-exposure categories: a systematic review and meta-analysisAIDS201428275127622549360110.1097/QAD.0000000000000494
BertagnolioSClinical impact of pretreatment human immunodeficiency virus drug resistance in people initiating nonnucleoside reverse transcriptase inhibitor–containing antiretroviral therapy: a systematic review and meta-analysisJ. Infect. Dis.20212243773881:CAS:528:DC%2BB3MXhslyju7bJ3320202510.1093/infdis/jiaa683
SidhuABSVerdier-PinardDFidockDAChloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutationsScience20022982102131:CAS:528:DC%2BD38XnsFSgs70%3D12364805295475810.1126/science.1074045
FokamJAlarming rates of virological failure and HIV-1 drug resistance amongst adolescents living with perinatal HIV in both urban and rural settings: evidence from the EDCTP READY-study in CameroonHiv. Med.2021225675801:CAS:528:DC%2BB3MXhslGjtLnM3379213410.1111/hiv.13095
MarsdenMDAvancenaPKitchenCMRHubbardTZackJASingle mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophagesAntimicrob. Agents Chemother.201155369637021:CAS:528:DC%2BC3MXpslGht74%3D21628534314763210.1128/AAC.00566-11
Eron, J. J. et al. Lenacapavir with bNAbs GS-5423 and GS-2872 dosed every 6 months in people with HIV. In Conf. Retroviruses and Opportunistic Infections 193 (Univ. North Carolina at Chapel Hill, 2023).
CoreyVCA broad analysis of resistance development in the malaria parasiteNat. Commun.201671:CAS:528:DC%2BC28XhtVaiu7nE27301419491261310.1038/ncomms11901
World Health Organization. Global Action Plan on HIV Drug Resistance 2017–2021: 2018 Progress Report—HIV Drug Resistance 14 (WHO, 2018).
LukensAKHarnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistanceProc. Natl Acad. Sci. USA20141117998041:CAS:528:DC%2BC2cXotFyhtg%3D%3D2438115710.1073/pnas.1320886110
SáJMArtemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus modelProc. Natl Acad. Sci. USA2018115125131251830455312629809310.1073/pnas.1813386115
GagneuxSThe competitive cost of antibiotic resistance in Mycobacterium tuberculosisScience2006312194419461:CAS:528:DC%2BD28XmsVahu7w%3D1680953810.1126/science.1124410
CoffinJMHIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapyScience19952674834891:CAS:528:DyaK2MXjsFShu7w%3D782494710.1126/science.7824947
CahnPDolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trialsLancet20193931431551:CAS:528:DC%2BC1cXitFKjsLnK3042012310.1016/S0140-6736(18)32462-0This work supports a new paradigm in drug combination by demonstrating the efficacy, non-inferiority and tolerability of a two-drug anti-HIV regimen over a three-drug regimen.
WalkerTMThe 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysisLancet Microbe20223e265e2731:CAS:528:DC%2BB38Xht1WmsLrI35373160761255410.1016/S2666-5247(21)00301-3
HarriganPRLarderBAExtent of cross-resistance between agents used to treat human immunodeficiency virus type 1 infection in clinically derived isolatesAntimicrob. Agents Chemother.2002469099121:CAS:528:DC%2BD38XhsVKgsrw%3D1185028612747410.1128/AAC.46.3.909-912.2002
BrooksDRSequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxineEur. J. Biochem.19942243974051:CAS:528:DyaK2cXmvFCis7o%3D792535310.1111/j.1432-1033.1994.00397.x
D’AntonioMTamayoPMesirovJPFrazerKAKataegis expression signature in breast cancer is associated with late onset, better prognosis, and higher HER2 levelsCell Rep.20161667268327373164497203010.1016/j.celrep.2016.06.026
BlascoBLeroyDFidockDAAntimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinicNat. Med.2017239179281:CAS:528:DC%2BC2sXht1yit7%2FO28777791574736310.1038/nm.4381
World Health Organization. WHO Guidelines for Malaria (WHO, 2021).
LucianiFSissonSAJiangHFrancisARTanakaMMThe epidemiological fitness cost of drug resistance in Mycobacterium tuberculosisProc. Natl Acad. Sci. USA200910614711147151:CAS:528:DC%2BD1MXhtFWqs73E19706556273289610.1073/pnas.0902437106
TrigliaTCowmanAFPrimary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparumProc. Natl Acad. Sci. USA199491714971531:CAS:528:DyaK2cXlvFOhu70%3D80417614435610.1073/pnas.91.15.7149
BanerjeeAinhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosisScience19942632272301:CAS:528:DyaK2cXhsFylt7c%3D828467310.1126/science.8284673
Rübsamen-WaigmannHResistance mutations selected in vivo under therapy with anti-HIV drug HBY 097 differ from resistance pattern selected in vitroAntivir. Res.19994215241033313910.1016/S0166-3542(99)00010-8
ComasIWhole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genesNat. Genet.20114410611022179134324653810.1038/ng.1038
WallerNJECheungC-YCookGMMcNeilM
AF Feder (933_CR45) 2021; 10
ED Weld (933_CR165) 2020; 15
K Konno (933_CR62) 1967; 95
A Burusie (933_CR206) 2020; 15
J O’Neill (933_CR2) 2016; 15
933_CR52
933_CR53
S Gagneux (933_CR133) 2006; 312
W Nyandiko (933_CR104) 2022; 89
F Conradie (933_CR9) 2022; 387
AN Cowell (933_CR141) 2018; 359
K Hjort (933_CR71) 2022; 225
JM Llibre (933_CR107) 2015; 17
S Loewenberg (933_CR222) 2012; 379
MN Bates (933_CR205) 2007; 167
LSM Huang (933_CR174) 2021; 73
RW van der Pluijm (933_CR209) 2019; 19
MF Chughlay (933_CR180) 2022; 66
M Prudêncio (933_CR189) 2006; 4
L Wei (933_CR176) 2021; 2
M Pai (933_CR76) 2016; 2
933_CR196
933_CR195
F Ariey (933_CR31) 2013; 505
933_CR199
B Witkowski (933_CR28) 2017; 17
LS Ross (933_CR25) 2018; 9
M Siribie (933_CR75) 2021; 11
933_CR194
NJE Waller (933_CR149) 2023; 14
DW Crook (933_CR128) 2022; 20
LM Mansky (933_CR36) 1995; 69
J Wang (933_CR4) 2019; 5
RK Gupta (933_CR220) 2009; 9
T Kálai (933_CR113) 2022; 4
933_CR185
933_CR184
M Saito (933_CR187) 2022; 401
S Delany-Moretlwe (933_CR166) 2022; 399
933_CR186
933_CR32
RP McClung (933_CR219) 2022; 74
WR Gimode (933_CR143) 2015; 14
G Kilinç (933_CR178) 2021; 301
K Singh (933_CR49) 2010; 2
Y Zhang (933_CR56) 2015; 19
GS Gottlieb (933_CR197) 2018; 5
VA Dartois (933_CR157) 2022; 20
ET Overton (933_CR163) 2021; 396
T Triglia (933_CR18) 1994; 91
MNL Nalam (933_CR138) 2013; 20
M Duffey (933_CR89) 2021; 37
P Supply (933_CR10) 2013; 45
RW van der Pluijm (933_CR78) 2021; 37
Y Yuthavong (933_CR136) 2012; 109
MA Wainberg (933_CR111) 2015; 6
MH Hazbón (933_CR66) 2006; 50
S Thaithong (933_CR15) 1992; 52
RT Gandhi (933_CR54) 2023; 329
H Taniguchi (933_CR58) 1996; 144
E Schwartz (933_CR19) 2003; 37
MD Marsden (933_CR44) 2011; 55
J Wang (933_CR30) 2017; 38
GV Bloemberg (933_CR68) 2015; 373
C Loiseau (933_CR134) 2023; 14
A Scorpio (933_CR63) 1996; 2
I Dicker (933_CR115) 2022; 66
933_CR168
H Rübsamen-Waigmann (933_CR108) 1999; 42
MD Marsden (933_CR139) 2020; 17
M Hu (933_CR55) 2015; 219
AF Cowman (933_CR13) 1988; 85
RS Boerma (933_CR215) 2017; 72
M Singh (933_CR161) 2022; 11
N Alipanah (933_CR119) 2018; 15
TM Walker (933_CR70) 2022; 3
M D’Antonio (933_CR142) 2016; 16
AS Perelson (933_CR41) 2013; 11
PR Harrigan (933_CR46) 2002; 46
J Zhu (933_CR112) 2015; 6
OJ Watson (933_CR158) 2022; 3
ABS Sidhu (933_CR22) 2002; 298
S-Y Rhee (933_CR42) 2016; 90
K Andries (933_CR123) 2005; 307
PL Tzou (933_CR43) 2020; 75
SG Deeks (933_CR171) 2021; 27
AM Thu (933_CR207) 2017; 284
B Balikagala (933_CR34) 2021; 385
B Chen (933_CR190) 2019; 27
DS Peterson (933_CR14) 1990; 87
HZ Farooq (933_CR127) 2021; 27
D Rifat (933_CR121) 2021; 65
SY Rhee (933_CR221) 2020; 23
NA Ismail (933_CR124) 2022; 22
H Nebenzahl-Guimaraes (933_CR69) 2014; 69
JM Sá (933_CR140) 2018; 115
PK Tumwebaze (933_CR211) 2022; 13
T Yoshinaga (933_CR94) 2019; 63
M Pascucci (933_CR160) 2021; 12
JM Coffin (933_CR40) 1995; 267
R Ramjan (933_CR98) 2014; 19
WI Sundquist (933_CR193) 2012; 2
S Sreevatsan (933_CR60) 1997; 41
K Stepniewska (933_CR156) 2022; 225
A Fun (933_CR51) 2012; 9
REK Mandt (933_CR90) 2023; 12
W An (933_CR38) 2022; 4
P Sawa (933_CR155) 2013; 207
WL Jorgensen (933_CR137) 2016; 24
V Lakshmanan (933_CR23) 2005; 24
SE Mudde (933_CR122) 2022; 77
MF Boni (933_CR73) 2008; 105
ME Abram (933_CR37) 2010; 84
J Furin (933_CR77) 2019; 393
H Song (933_CR39) 2018; 9
AM Dondorp (933_CR154) 2009; 361
R Leang (933_CR210) 2015; 59
MF Boni (933_CR74) 2016; 13
JM Carlton (933_CR85) 2018; 359
A Llanos-Cuentas (933_CR83) 2018; 18
RN Price (933_CR27) 2004; 364
A Cowell (933_CR86) 2018; 11
SR Meshnick (933_CR20) 2005; 191
AM Dondorp (933_CR81) 2010; 8
SG Deeks (933_CR35) 2015; 1
AA Witney (933_CR126) 2017; 15
M Melku (933_CR105) 2022; 17
A Banerjee (933_CR59) 1994; 263
E Ramon (933_CR106) 2019; 20
AA Velayati (933_CR223) 2009; 136
EK Schmitt (933_CR84) 2021; 74
B Hanboonkunupakarn (933_CR80) 2022; 13
J Timm Id (933_CR125) 2023; 3
K Anstett (933_CR109) 2017; 14
MI Gröschel (933_CR129) 2021; 13
JB Nachega (933_CR162) 2023; 10
AK Lukens (933_CR151) 2014; 111
W Deelder (933_CR130) 2019; 10
C Young (933_CR177) 2020; 13
MJ Boeree (933_CR183) 2021; 25
933_CR214
QD Pham (933_CR216) 2014; 28
A Tseng (933_CR92) 2015; 79
JO Link (933_CR48) 2020; 584
JS McCarthy (933_CR82) 2021; 21
D Loesbanluechai (933_CR29) 2019; 9
AM Wensing (933_CR100) 2019; 27
S Bertagnolio (933_CR102) 2022; 17
V Zila (933_CR192) 2021; 184
T Xiao (933_CR47) 2021; 13
F Luciani (933_CR135) 2009; 106
UH Manjunatha (933_CR64) 2006; 103
SE Dorman (933_CR118) 2021; 384
LB Arendse (933_CR144) 2021; 7
RL Wu (933_CR172) 2022; 387
J Fokam (933_CR103) 2021; 22
JM Whitcomb (933_CR97) 2003; 188
K Das (933_CR95) 2004; 47
C Orkin (933_CR99) 2020; 382
B Blasco (933_CR208) 2017; 23
S Segal-Maurer (933_CR164) 2022; 386
M Kim (933_CR170) 2022; 13
RW van der Pluijm (933_CR153) 2020; 395
DV Havlir (933_CR201) 2008; 300
M Karmakar (933_CR159) 2022; 22
RC Hartkoorn (933_CR67) 2014; 58
933_CR213
933_CR212
H Mohamed (933_CR173) 2022; 12
HL Haver (933_CR120) 2015; 59
DA Fidock (933_CR6) 2021; 2
T Maehigashi (933_CR116) 2021; 17
933_CR5
933_CR8
933_CR7
S Kanters (933_CR91) 2016; 3
VC Corey (933_CR87) 2016; 7
AM Dondorp (933_CR33) 2016; 4
RMGJ Houben (933_CR198) 2016; 13
NA Meanwell (933_CR181) 2018; 61
I Comas (933_CR72) 2011; 44
933_CR12
SM Gygli (933_CR57) 2017; 41
933_CR200
J Gregson (933_CR218) 2016; 16
S Bopp (933_CR150) 2023; 14
W Carr (933_CR188) 2022; 71
EG Tse (933_CR11) 2019; 18
B Bosch (933_CR146) 2021; 184
AH Lee (933_CR88) 2016; 11
X Kuang (933_CR131) 2022; 12
S You (933_CR132) 2022; 1
M Sulkowski (933_CR182) 2012; 56
W Sirawaraporn (933_CR16) 1997; 94
C Flexner (933_CR169) 2022; 17
N Obore (933_CR203) 2020; 187
SK Dhingra (933_CR24) 2019; 19
AL Pickard (933_CR26) 2003; 47
TJ Peto (933_CR79) 2022; 22
RJ Landovitz (933_CR167) 2021; 385
A Dharan (933_CR191) 2020; 5
M Boffito (933_CR93) 2020; 36
K Parcella (933_CR114) 2022; 13
GP Morlock (933_CR65) 2003; 47
G Napier (933_CR147) 2023; 13
MC Puertas (933_CR217) 2020; 1
DR Brooks (933_CR17) 1994; 224
K Lönnroth (933_CR202) 2010; 375
L Menéndez-Arias (933_CR50) 2008; 134
S Lamotte (933_CR175) 2017; 11
B Heym (933_CR61) 1995; 15
P Cahn (933_CR96) 2019; 393
A Djimdé (933_CR21) 2001; 344
CA Kerantzas (933_CR117) 2017; 8
D Paul (933_CR145) 2021; 26
S Bertagnolio (933_CR101) 2021; 224
HD Chien (933_CR179) 2021; 218
CY Jeon (933_CR204) 2008; 5
R van Duyne (933_CR110) 2019; 116
933_CR1
J Gill (933_CR148) 2022; 15
933_CR3
L Imamovic (933_CR152) 2013; 5
References_xml – volume: 15
  year: 2020
  ident: 933_CR206
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0239333
  contributor:
    fullname: A Burusie
– volume: 11
  start-page: 2634
  year: 2022
  ident: 933_CR161
  publication-title: Electronics
  doi: 10.3390/electronics11172634
  contributor:
    fullname: M Singh
– volume: 63
  start-page: e02104
  year: 2019
  ident: 933_CR94
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.02104-18
  contributor:
    fullname: T Yoshinaga
– volume: 79
  start-page: 182
  year: 2015
  ident: 933_CR92
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1111/bcp.12403
  contributor:
    fullname: A Tseng
– volume: 373
  start-page: 1986
  year: 2015
  ident: 933_CR68
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc1505196
  contributor:
    fullname: GV Bloemberg
– volume: 75
  start-page: 170
  year: 2020
  ident: 933_CR43
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkz417
  contributor:
    fullname: PL Tzou
– volume: 4
  start-page: 849
  year: 2006
  ident: 933_CR189
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro1529
  contributor:
    fullname: M Prudêncio
– ident: 933_CR194
– volume: 225
  start-page: 1011
  year: 2022
  ident: 933_CR71
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jiaa625
  contributor:
    fullname: K Hjort
– volume: 27
  start-page: 111
  year: 2019
  ident: 933_CR100
  publication-title: Top. Antivir. Med.
  contributor:
    fullname: AM Wensing
– volume: 89
  start-page: 231
  year: 2022
  ident: 933_CR104
  publication-title: J. Acquir. Immune Defic. Syndr.
  doi: 10.1097/QAI.0000000000002850
  contributor:
    fullname: W Nyandiko
– volume: 37
  start-page: 709
  year: 2021
  ident: 933_CR89
  publication-title: Trends Parasitol.
  doi: 10.1016/j.pt.2021.04.006
  contributor:
    fullname: M Duffey
– volume: 19
  start-page: 1168
  year: 2019
  ident: 933_CR24
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(19)30543-2
  contributor:
    fullname: SK Dhingra
– volume: 364
  start-page: 438
  year: 2004
  ident: 933_CR27
  publication-title: Lancet
  doi: 10.1016/S0140-6736(04)16767-6
  contributor:
    fullname: RN Price
– volume: 20
  start-page: 1116
  year: 2013
  ident: 933_CR138
  publication-title: Chem. Biol.
  doi: 10.1016/j.chembiol.2013.07.014
  contributor:
    fullname: MNL Nalam
– volume: 17
  year: 2021
  ident: 933_CR116
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1009671
  contributor:
    fullname: T Maehigashi
– ident: 933_CR1
– volume: 3
  year: 2023
  ident: 933_CR125
  publication-title: PLOS Glob. Public. Health
  doi: 10.1371/journal.pgph.0002283
  contributor:
    fullname: J Timm Id
– volume: 20
  start-page: 685
  year: 2022
  ident: 933_CR157
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/s41579-022-00731-y
  contributor:
    fullname: VA Dartois
– volume: 3
  start-page: e701
  year: 2022
  ident: 933_CR158
  publication-title: Lancet Microbe
  doi: 10.1016/S2666-5247(22)00155-0
  contributor:
    fullname: OJ Watson
– volume: 13
  year: 2023
  ident: 933_CR147
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-023-27516-4
  contributor:
    fullname: G Napier
– volume: 6
  start-page: 90
  year: 2015
  ident: 933_CR111
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2015.00090
  contributor:
    fullname: MA Wainberg
– volume: 184
  start-page: 4579
  year: 2021
  ident: 933_CR146
  publication-title: Cell
  doi: 10.1016/j.cell.2021.06.033
  contributor:
    fullname: B Bosch
– volume: 300
  start-page: 423
  year: 2008
  ident: 933_CR201
  publication-title: JAMA
  doi: 10.1001/jama.300.4.423
  contributor:
    fullname: DV Havlir
– ident: 933_CR199
– volume: 263
  start-page: 227
  year: 1994
  ident: 933_CR59
  publication-title: Science
  doi: 10.1126/science.8284673
  contributor:
    fullname: A Banerjee
– volume: 11
  year: 2021
  ident: 933_CR75
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2020-040220
  contributor:
    fullname: M Siribie
– volume: 38
  start-page: 506
  year: 2017
  ident: 933_CR30
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2017.03.007
  contributor:
    fullname: J Wang
– volume: 105
  start-page: 14216
  year: 2008
  ident: 933_CR73
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0804628105
  contributor:
    fullname: MF Boni
– volume: 14
  start-page: 1
  year: 2017
  ident: 933_CR109
  publication-title: Retrovirology
  doi: 10.1186/s12977-017-0360-7
  contributor:
    fullname: K Anstett
– volume: 399
  start-page: 1779
  year: 2022
  ident: 933_CR166
  publication-title: Lancet
  doi: 10.1016/S0140-6736(22)00538-4
  contributor:
    fullname: S Delany-Moretlwe
– volume: 27
  start-page: 2085
  year: 2021
  ident: 933_CR171
  publication-title: Nat. Med.
  doi: 10.1038/s41591-021-01590-5
  contributor:
    fullname: SG Deeks
– volume: 59
  start-page: 5316
  year: 2015
  ident: 933_CR120
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00308-15
  contributor:
    fullname: HL Haver
– volume: 115
  start-page: 12513
  year: 2018
  ident: 933_CR140
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1813386115
  contributor:
    fullname: JM Sá
– volume: 5
  start-page: 1091
  year: 2008
  ident: 933_CR204
  publication-title: PLoS Med.
  contributor:
    fullname: CY Jeon
– volume: 74
  start-page: 1055
  year: 2022
  ident: 933_CR219
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciab583
  contributor:
    fullname: RP McClung
– volume: 69
  start-page: 5087
  year: 1995
  ident: 933_CR36
  publication-title: J. Virol.
  doi: 10.1128/jvi.69.8.5087-5094.1995
  contributor:
    fullname: LM Mansky
– volume: 7
  year: 2016
  ident: 933_CR87
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11901
  contributor:
    fullname: VC Corey
– volume: 71
  start-page: 285
  year: 2022
  ident: 933_CR188
  publication-title: MMWR Morb. Mortal. Wkly. Rep.
  doi: 10.15585/mmwr.mm7108a1
  contributor:
    fullname: W Carr
– volume: 387
  start-page: 810
  year: 2022
  ident: 933_CR9
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2119430
  contributor:
    fullname: F Conradie
– volume: 19
  start-page: 501
  year: 2014
  ident: 933_CR98
  publication-title: Trop. Med. Int. Health
  doi: 10.1111/tmi.12297
  contributor:
    fullname: R Ramjan
– volume: 4
  start-page: 216
  year: 2022
  ident: 933_CR113
  publication-title: Chemistry
  doi: 10.3390/chemistry4020019
  contributor:
    fullname: T Kálai
– volume: 20
  year: 2022
  ident: 933_CR128
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.3001721
  contributor:
    fullname: DW Crook
– volume: 384
  start-page: 1705
  year: 2021
  ident: 933_CR118
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2033400
  contributor:
    fullname: SE Dorman
– volume: 13
  start-page: 735
  year: 2021
  ident: 933_CR47
  publication-title: Viruses
  doi: 10.3390/v13050735
  contributor:
    fullname: T Xiao
– volume: 395
  start-page: 1345
  year: 2020
  ident: 933_CR153
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30552-3
  contributor:
    fullname: RW van der Pluijm
– volume: 2
  start-page: 606
  year: 2010
  ident: 933_CR49
  publication-title: Viruses
  doi: 10.3390/v2020606
  contributor:
    fullname: K Singh
– volume: 144
  start-page: 103
  year: 1996
  ident: 933_CR58
  publication-title: FEMS Microbiol. Lett.
  doi: 10.1111/j.1574-6968.1996.tb08515.x
  contributor:
    fullname: H Taniguchi
– volume: 307
  start-page: 223
  year: 2005
  ident: 933_CR123
  publication-title: Science
  doi: 10.1126/science.1106753
  contributor:
    fullname: K Andries
– ident: 933_CR7
– volume: 36
  start-page: 13
  year: 2020
  ident: 933_CR93
  publication-title: AIDS Res. Hum. Retroviruses
  doi: 10.1089/aid.2019.0171
  contributor:
    fullname: M Boffito
– volume: 13
  start-page: 1
  year: 2021
  ident: 933_CR129
  publication-title: Genome Med.
  doi: 10.1186/s13073-021-00953-4
  contributor:
    fullname: MI Gröschel
– volume: 14
  year: 2015
  ident: 933_CR143
  publication-title: Malar. J.
  doi: 10.1186/s12936-015-0550-5
  contributor:
    fullname: WR Gimode
– volume: 56
  start-page: S560
  year: 2012
  ident: 933_CR182
  publication-title: J. Hepatol.
  contributor:
    fullname: M Sulkowski
– volume: 12
  start-page: 1
  year: 2022
  ident: 933_CR131
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-022-06449-4
  contributor:
    fullname: X Kuang
– volume: 584
  start-page: 614
  year: 2020
  ident: 933_CR48
  publication-title: Nature
  doi: 10.1038/s41586-020-2443-1
  contributor:
    fullname: JO Link
– volume: 20
  start-page: 1
  year: 2019
  ident: 933_CR106
  publication-title: BMC Bioinforma.
  doi: 10.1186/s12859-019-2991-2
  contributor:
    fullname: E Ramon
– volume: 191
  start-page: 822
  year: 2005
  ident: 933_CR20
  publication-title: J. Infect. Dis.
  doi: 10.1086/427782
  contributor:
    fullname: SR Meshnick
– volume: 136
  start-page: 420
  year: 2009
  ident: 933_CR223
  publication-title: Chest
  doi: 10.1378/chest.08-2427
  contributor:
    fullname: AA Velayati
– volume: 385
  start-page: 595
  year: 2021
  ident: 933_CR167
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2101016
  contributor:
    fullname: RJ Landovitz
– volume: 344
  start-page: 257
  year: 2001
  ident: 933_CR21
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM200101253440403
  contributor:
    fullname: A Djimdé
– volume: 15
  start-page: 33
  year: 2020
  ident: 933_CR165
  publication-title: Curr. Opin. Hiv. AIDS
  doi: 10.1097/COH.0000000000000591
  contributor:
    fullname: ED Weld
– volume: 505
  start-page: 50
  year: 2013
  ident: 933_CR31
  publication-title: Nature
  doi: 10.1038/nature12876
  contributor:
    fullname: F Ariey
– volume: 47
  start-page: 2550
  year: 2004
  ident: 933_CR95
  publication-title: J. Med. Chem.
  doi: 10.1021/jm030558s
  contributor:
    fullname: K Das
– volume: 379
  start-page: 205
  year: 2012
  ident: 933_CR222
  publication-title: Lancet
  doi: 10.1016/S0140-6736(12)60085-3
  contributor:
    fullname: S Loewenberg
– volume: 9
  year: 2012
  ident: 933_CR51
  publication-title: Retrovirology
  doi: 10.1186/1742-4690-9-63
  contributor:
    fullname: A Fun
– volume: 184
  start-page: 1032
  year: 2021
  ident: 933_CR192
  publication-title: Cell
  doi: 10.1016/j.cell.2021.01.025
  contributor:
    fullname: V Zila
– volume: 219
  start-page: 681
  year: 2015
  ident: 933_CR55
  publication-title: J. Control. Rel.
  doi: 10.1016/j.jconrel.2015.08.018
  contributor:
    fullname: M Hu
– volume: 17
  start-page: 1
  year: 2020
  ident: 933_CR139
  publication-title: Retrovirology
  doi: 10.1186/s12977-020-00516-2
  contributor:
    fullname: MD Marsden
– volume: 69
  start-page: 331
  year: 2014
  ident: 933_CR69
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkt358
  contributor:
    fullname: H Nebenzahl-Guimaraes
– volume: 18
  year: 2019
  ident: 933_CR11
  publication-title: Malar. J.
  doi: 10.1186/s12936-019-2724-z
  contributor:
    fullname: EG Tse
– volume: 284
  start-page: 2569
  year: 2017
  ident: 933_CR207
  publication-title: FEBS J.
  doi: 10.1111/febs.14127
  contributor:
    fullname: AM Thu
– ident: 933_CR184
– volume: 382
  start-page: 1124
  year: 2020
  ident: 933_CR99
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1909512
  contributor:
    fullname: C Orkin
– volume: 1
  start-page: 130
  year: 2020
  ident: 933_CR217
  publication-title: Artic. Lancet Microbe
  doi: 10.1016/S2666-5247(20)30006-9
  contributor:
    fullname: MC Puertas
– volume: 375
  start-page: 1814
  year: 2010
  ident: 933_CR202
  publication-title: Lancet
  doi: 10.1016/S0140-6736(10)60483-7
  contributor:
    fullname: K Lönnroth
– volume: 13
  start-page: 1
  year: 2022
  ident: 933_CR211
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-33873-x
  contributor:
    fullname: PK Tumwebaze
– volume: 59
  start-page: 4719
  year: 2015
  ident: 933_CR210
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00835-15
  contributor:
    fullname: R Leang
– volume: 188
  start-page: 992
  year: 2003
  ident: 933_CR97
  publication-title: J. Infect. Dis.
  doi: 10.1086/378281
  contributor:
    fullname: JM Whitcomb
– ident: 933_CR195
– volume: 13
  start-page: 1
  year: 2022
  ident: 933_CR170
  publication-title: Nat. Commun.
  contributor:
    fullname: M Kim
– volume: 5
  start-page: e390
  year: 2018
  ident: 933_CR197
  publication-title: Lancet HIV
  doi: 10.1016/S2352-3018(18)30094-8
  contributor:
    fullname: GS Gottlieb
– volume: 2
  start-page: 1287
  year: 2021
  ident: 933_CR6
  publication-title: Med
  doi: 10.1016/j.medj.2021.11.005
  contributor:
    fullname: DA Fidock
– volume: 7
  start-page: 518
  year: 2021
  ident: 933_CR144
  publication-title: ACS Infect. Dis.
  doi: 10.1021/acsinfecdis.0c00724
  contributor:
    fullname: LB Arendse
– volume: 386
  start-page: 1793
  year: 2022
  ident: 933_CR164
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2115542
  contributor:
    fullname: S Segal-Maurer
– volume: 50
  start-page: 2640
  year: 2006
  ident: 933_CR66
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00112-06
  contributor:
    fullname: MH Hazbón
– volume: 22
  start-page: 1
  year: 2022
  ident: 933_CR159
  publication-title: BMC Infect. Dis.
  doi: 10.1186/s12879-022-07067-1
  contributor:
    fullname: M Karmakar
– volume: 9
  start-page: 16
  year: 2019
  ident: 933_CR29
  publication-title: Int. J. Parasitol. Drugs Drug. Resist.
  doi: 10.1016/j.ijpddr.2018.11.004
  contributor:
    fullname: D Loesbanluechai
– volume: 3
  start-page: e510
  year: 2016
  ident: 933_CR91
  publication-title: Lancet Hiv.
  doi: 10.1016/S2352-3018(16)30091-1
  contributor:
    fullname: S Kanters
– volume: 2
  start-page: a006924
  year: 2012
  ident: 933_CR193
  publication-title: Cold Spring Harb. Perspect. Med.
  doi: 10.1101/cshperspect.a006924
  contributor:
    fullname: WI Sundquist
– ident: 933_CR200
– volume: 3
  start-page: e265
  year: 2022
  ident: 933_CR70
  publication-title: Lancet Microbe
  doi: 10.1016/S2666-5247(21)00301-3
  contributor:
    fullname: TM Walker
– volume: 23
  year: 2020
  ident: 933_CR221
  publication-title: J. Int. AIDS Soc.
  doi: 10.1002/jia2.25611
  contributor:
    fullname: SY Rhee
– volume: 17
  year: 2022
  ident: 933_CR105
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0267159
  contributor:
    fullname: M Melku
– volume: 11
  year: 2013
  ident: 933_CR41
  publication-title: BMC Biol.
  doi: 10.1186/1741-7007-11-96
  contributor:
    fullname: AS Perelson
– volume: 16
  start-page: 672
  year: 2016
  ident: 933_CR142
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.06.026
  contributor:
    fullname: M D’Antonio
– ident: 933_CR196
– ident: 933_CR8
– volume: 11
  start-page: 117863611880852
  year: 2018
  ident: 933_CR86
  publication-title: Microbiol. Insights
  doi: 10.1177/1178636118808529
  contributor:
    fullname: A Cowell
– volume: 5
  start-page: 32
  year: 2019
  ident: 933_CR4
  publication-title: Engineering
  doi: 10.1016/j.eng.2018.11.011
  contributor:
    fullname: J Wang
– volume: 55
  start-page: 3696
  year: 2011
  ident: 933_CR44
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00566-11
  contributor:
    fullname: MD Marsden
– volume: 14
  start-page: 1
  year: 2023
  ident: 933_CR149
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-37184-7
  contributor:
    fullname: NJE Waller
– volume: 12
  year: 2023
  ident: 933_CR90
  publication-title: eLife
  doi: 10.7554/eLife.85023
  contributor:
    fullname: REK Mandt
– volume: 401
  start-page: 118
  year: 2022
  ident: 933_CR187
  publication-title: Lancet
  doi: 10.1016/S0140-6736(22)01881-5
  contributor:
    fullname: M Saito
– volume: 77
  start-page: 880
  year: 2022
  ident: 933_CR122
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkab505
  contributor:
    fullname: SE Mudde
– volume: 109
  start-page: 16823
  year: 2012
  ident: 933_CR136
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1204556109
  contributor:
    fullname: Y Yuthavong
– volume: 47
  start-page: 3799
  year: 2003
  ident: 933_CR65
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.47.12.3799-3805.2003
  contributor:
    fullname: GP Morlock
– volume: 21
  start-page: 1713
  year: 2021
  ident: 933_CR82
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(21)00252-8
  contributor:
    fullname: JS McCarthy
– volume: 19
  start-page: 952
  year: 2019
  ident: 933_CR209
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(19)30391-3
  contributor:
    fullname: RW van der Pluijm
– volume: 111
  start-page: 799
  year: 2014
  ident: 933_CR151
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1320886110
  contributor:
    fullname: AK Lukens
– volume: 10
  start-page: 922
  year: 2019
  ident: 933_CR130
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2019.00922
  contributor:
    fullname: W Deelder
– ident: 933_CR32
– volume: 224
  start-page: 377
  year: 2021
  ident: 933_CR101
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jiaa683
  contributor:
    fullname: S Bertagnolio
– volume: 17
  start-page: 56
  year: 2015
  ident: 933_CR107
  publication-title: AIDS Rev.
  contributor:
    fullname: JM Llibre
– volume: 10
  start-page: e332
  year: 2023
  ident: 933_CR162
  publication-title: Lancet HIV
  doi: 10.1016/S2352-3018(23)00051-6
  contributor:
    fullname: JB Nachega
– ident: 933_CR3
– volume: 87
  start-page: 3018
  year: 1990
  ident: 933_CR14
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.87.8.3018
  contributor:
    fullname: DS Peterson
– volume: 37
  start-page: 15
  year: 2021
  ident: 933_CR78
  publication-title: Trends Parasitol.
  doi: 10.1016/j.pt.2020.09.011
  contributor:
    fullname: RW van der Pluijm
– volume: 11
  year: 2017
  ident: 933_CR175
  publication-title: PLoS Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0005480
  contributor:
    fullname: S Lamotte
– volume: 19
  start-page: 1276
  year: 2015
  ident: 933_CR56
  publication-title: Int. J. Tuberculosis Lung Dis.
  doi: 10.5588/ijtld.15.0389
  contributor:
    fullname: Y Zhang
– volume: 13
  year: 2016
  ident: 933_CR74
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1001984
  contributor:
    fullname: MF Boni
– volume: 134
  start-page: 124
  year: 2008
  ident: 933_CR50
  publication-title: Virus Res.
  doi: 10.1016/j.virusres.2007.12.015
  contributor:
    fullname: L Menéndez-Arias
– volume: 26
  start-page: 80
  year: 2021
  ident: 933_CR145
  publication-title: Drug. Discov. Today
  doi: 10.1016/j.drudis.2020.10.010
  contributor:
    fullname: D Paul
– volume: 4
  start-page: 195
  year: 2022
  ident: 933_CR38
  publication-title: AIDS Rev.
  contributor:
    fullname: W An
– volume: 17
  start-page: 229
  year: 2022
  ident: 933_CR102
  publication-title: Curr. Opin. Hiv. AIDS
  doi: 10.1097/COH.0000000000000743
  contributor:
    fullname: S Bertagnolio
– volume: 15
  year: 2017
  ident: 933_CR126
  publication-title: BMC Med
  doi: 10.1186/s12916-017-0834-4
  contributor:
    fullname: AA Witney
– volume: 16
  start-page: 565
  year: 2016
  ident: 933_CR218
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(15)00536-8
  contributor:
    fullname: J Gregson
– volume: 90
  start-page: 6058
  year: 2016
  ident: 933_CR42
  publication-title: J. Virol.
  doi: 10.1128/JVI.00495-16
  contributor:
    fullname: S-Y Rhee
– volume: 393
  start-page: 143
  year: 2019
  ident: 933_CR96
  publication-title: Lancet
  doi: 10.1016/S0140-6736(18)32462-0
  contributor:
    fullname: P Cahn
– ident: 933_CR213
– volume: 85
  start-page: 9109
  year: 1988
  ident: 933_CR13
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.85.23.9109
  contributor:
    fullname: AF Cowman
– volume: 10
  year: 2021
  ident: 933_CR45
  publication-title: eLife
  doi: 10.7554/eLife.69032
  contributor:
    fullname: AF Feder
– volume: 24
  start-page: 2294
  year: 2005
  ident: 933_CR23
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600681
  contributor:
    fullname: V Lakshmanan
– volume: 103
  start-page: 431
  year: 2006
  ident: 933_CR64
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0508392103
  contributor:
    fullname: UH Manjunatha
– volume: 66
  start-page: e01876
  year: 2022
  ident: 933_CR115
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.01876-21
  contributor:
    fullname: I Dicker
– volume: 385
  start-page: 1163
  year: 2021
  ident: 933_CR34
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2101746
  contributor:
    fullname: B Balikagala
– volume: 12
  start-page: 1
  year: 2021
  ident: 933_CR160
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21187-3
  contributor:
    fullname: M Pascucci
– volume: 359
  start-page: 159
  year: 2018
  ident: 933_CR85
  publication-title: Science
  doi: 10.1126/science.aar4189
  contributor:
    fullname: JM Carlton
– volume: 27
  start-page: 985
  year: 2021
  ident: 933_CR127
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2703.204418
  contributor:
    fullname: HZ Farooq
– volume: 22
  start-page: 567
  year: 2021
  ident: 933_CR103
  publication-title: Hiv. Med.
  doi: 10.1111/hiv.13095
  contributor:
    fullname: J Fokam
– volume: 24
  start-page: 4768
  year: 2016
  ident: 933_CR137
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2016.07.039
  contributor:
    fullname: WL Jorgensen
– ident: 933_CR168
– volume: 28
  start-page: 2751
  year: 2014
  ident: 933_CR216
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000000494
  contributor:
    fullname: QD Pham
– volume: 61
  start-page: 62
  year: 2018
  ident: 933_CR181
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.7b01337
  contributor:
    fullname: NA Meanwell
– volume: 167
  start-page: 335
  year: 2007
  ident: 933_CR205
  publication-title: Arch. Intern. Med.
  doi: 10.1001/archinte.167.4.335
  contributor:
    fullname: MN Bates
– volume: 22
  start-page: 867
  year: 2022
  ident: 933_CR79
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(21)00692-7
  contributor:
    fullname: TJ Peto
– volume: 267
  start-page: 483
  year: 1995
  ident: 933_CR40
  publication-title: Science
  doi: 10.1126/science.7824947
  contributor:
    fullname: JM Coffin
– volume: 8
  start-page: e01586
  year: 2017
  ident: 933_CR117
  publication-title: mBio
  doi: 10.1128/mBio.01586-16
  contributor:
    fullname: CA Kerantzas
– volume: 45
  start-page: 172
  year: 2013
  ident: 933_CR10
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2517
  contributor:
    fullname: P Supply
– volume: 2
  start-page: 100423
  year: 2021
  ident: 933_CR176
  publication-title: Cell Rep. Med.
  doi: 10.1016/j.xcrm.2021.100423
  contributor:
    fullname: L Wei
– volume: 15
  start-page: 235
  year: 1995
  ident: 933_CR61
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.1995.tb02238.x
  contributor:
    fullname: B Heym
– volume: 301
  start-page: 62
  year: 2021
  ident: 933_CR178
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12951
  contributor:
    fullname: G Kilinç
– ident: 933_CR185
– volume: 94
  start-page: 1124
  year: 1997
  ident: 933_CR16
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.94.4.1124
  contributor:
    fullname: W Sirawaraporn
– volume: 15
  year: 2018
  ident: 933_CR119
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.1002595
  contributor:
    fullname: N Alipanah
– volume: 65
  start-page: e01948
  year: 2021
  ident: 933_CR121
  publication-title: Antimicrob. Agents Chemother.
  contributor:
    fullname: D Rifat
– volume: 225
  start-page: 1215
  year: 2022
  ident: 933_CR156
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jiaa498
  contributor:
    fullname: K Stepniewska
– volume: 14
  start-page: 1
  year: 2023
  ident: 933_CR150
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-36921-2
  contributor:
    fullname: S Bopp
– volume: 12
  start-page: 5686
  year: 2022
  ident: 933_CR173
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.816515
  contributor:
    fullname: H Mohamed
– volume: 13
  year: 2016
  ident: 933_CR198
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.1002152
  contributor:
    fullname: RMGJ Houben
– ident: 933_CR186
– volume: 13
  start-page: 876282
  year: 2022
  ident: 933_CR80
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2022.876282
  contributor:
    fullname: B Hanboonkunupakarn
– ident: 933_CR53
– volume: 359
  start-page: 191
  year: 2018
  ident: 933_CR141
  publication-title: Science
  doi: 10.1126/science.aan4472
  contributor:
    fullname: AN Cowell
– ident: 933_CR212
– volume: 393
  start-page: 1642
  year: 2019
  ident: 933_CR77
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)30308-3
  contributor:
    fullname: J Furin
– volume: 13
  start-page: 190
  year: 2020
  ident: 933_CR177
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-019-0226-5
  contributor:
    fullname: C Young
– volume: 361
  start-page: 455
  year: 2009
  ident: 933_CR154
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0808859
  contributor:
    fullname: AM Dondorp
– volume: 2
  start-page: 662
  year: 1996
  ident: 933_CR63
  publication-title: Nat. Med.
  doi: 10.1038/nm0696-662
  contributor:
    fullname: A Scorpio
– volume: 396
  start-page: 1994
  year: 2021
  ident: 933_CR163
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)32666-0
  contributor:
    fullname: ET Overton
– volume: 23
  start-page: 917
  year: 2017
  ident: 933_CR208
  publication-title: Nat. Med.
  doi: 10.1038/nm.4381
  contributor:
    fullname: B Blasco
– volume: 106
  start-page: 14711
  year: 2009
  ident: 933_CR135
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0902437106
  contributor:
    fullname: F Luciani
– volume: 116
  start-page: 9040
  year: 2019
  ident: 933_CR110
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1820333116
  contributor:
    fullname: R van Duyne
– volume: 312
  start-page: 1944
  year: 2006
  ident: 933_CR133
  publication-title: Science
  doi: 10.1126/science.1124410
  contributor:
    fullname: S Gagneux
– volume: 218
  year: 2021
  ident: 933_CR179
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20210724
  contributor:
    fullname: HD Chien
– volume: 73
  start-page: 919
  year: 2021
  ident: 933_CR174
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciab160
  contributor:
    fullname: LSM Huang
– volume: 15
  start-page: 1
  year: 2022
  ident: 933_CR148
  publication-title: Parasit. Vectors
  doi: 10.1186/s13071-022-05422-4
  contributor:
    fullname: J Gill
– volume: 9
  year: 2018
  ident: 933_CR39
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-04217-5
  contributor:
    fullname: H Song
– volume: 66
  start-page: 1584
  year: 2022
  ident: 933_CR180
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.01584-21
  contributor:
    fullname: MF Chughlay
– volume: 6
  start-page: 517
  year: 2015
  ident: 933_CR112
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2015.00517
  contributor:
    fullname: J Zhu
– volume: 8
  start-page: 272
  year: 2010
  ident: 933_CR81
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2331
  contributor:
    fullname: AM Dondorp
– volume: 5
  start-page: 1088
  year: 2020
  ident: 933_CR191
  publication-title: Nat. Microbiol.
  doi: 10.1038/s41564-020-0735-8
  contributor:
    fullname: A Dharan
– volume: 15
  start-page: 526
  year: 2016
  ident: 933_CR2
  publication-title: Nat. Rev. Drug. Discov.
  doi: 10.1038/nrd.2016.160
  contributor:
    fullname: J O’Neill
– volume: 72
  start-page: 365
  year: 2017
  ident: 933_CR215
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkw463
  contributor:
    fullname: RS Boerma
– volume: 22
  start-page: 496
  year: 2022
  ident: 933_CR124
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(21)00470-9
  contributor:
    fullname: NA Ismail
– volume: 9
  start-page: 409
  year: 2009
  ident: 933_CR220
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(09)70136-7
  contributor:
    fullname: RK Gupta
– volume: 47
  start-page: 2418
  year: 2003
  ident: 933_CR26
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.47.8.2418-2423.2003
  contributor:
    fullname: AL Pickard
– volume: 1
  year: 2022
  ident: 933_CR132
  publication-title: PLOS Digital Health
  doi: 10.1371/journal.pdig.0000059
  contributor:
    fullname: S You
– volume: 14
  start-page: 1
  year: 2023
  ident: 933_CR134
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-37719-y
  contributor:
    fullname: C Loiseau
– volume: 13
  start-page: 972
  year: 2022
  ident: 933_CR114
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/acsmedchemlett.2c00115
  contributor:
    fullname: K Parcella
– ident: 933_CR214
– volume: 46
  start-page: 909
  year: 2002
  ident: 933_CR46
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.46.3.909-912.2002
  contributor:
    fullname: PR Harrigan
– volume: 41
  start-page: 1677
  year: 1997
  ident: 933_CR60
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.41.8.1677
  contributor:
    fullname: S Sreevatsan
– ident: 933_CR5
– volume: 41
  start-page: 354
  year: 2017
  ident: 933_CR57
  publication-title: FEMS Microbiol. Rev.
  doi: 10.1093/femsre/fux011
  contributor:
    fullname: SM Gygli
– volume: 5
  start-page: 204ra132
  year: 2013
  ident: 933_CR152
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3006609
  contributor:
    fullname: L Imamovic
– volume: 52
  start-page: 149
  year: 1992
  ident: 933_CR15
  publication-title: Mol. Biochem. Parasitol.
  doi: 10.1016/0166-6851(92)90047-N
  contributor:
    fullname: S Thaithong
– volume: 4
  start-page: 409
  year: 2016
  ident: 933_CR33
  publication-title: Microbiol. Spectrum
  contributor:
    fullname: AM Dondorp
– volume: 27
  start-page: 878
  year: 2019
  ident: 933_CR190
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2019.06.002
  contributor:
    fullname: B Chen
– volume: 37
  start-page: 450
  year: 2003
  ident: 933_CR19
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/375599
  contributor:
    fullname: E Schwartz
– volume: 17
  start-page: 174
  year: 2017
  ident: 933_CR28
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(16)30415-7
  contributor:
    fullname: B Witkowski
– volume: 329
  start-page: 63
  year: 2023
  ident: 933_CR54
  publication-title: JAMA
  doi: 10.1001/jama.2022.22246
  contributor:
    fullname: RT Gandhi
– ident: 933_CR52
– volume: 74
  start-page: 1831
  year: 2021
  ident: 933_CR84
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciab716
  contributor:
    fullname: EK Schmitt
– volume: 95
  start-page: 461
  year: 1967
  ident: 933_CR62
  publication-title: Am. Rev. Respir. Dis.
  contributor:
    fullname: K Konno
– volume: 224
  start-page: 397
  year: 1994
  ident: 933_CR17
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1994.00397.x
  contributor:
    fullname: DR Brooks
– volume: 1
  start-page: 1
  year: 2015
  ident: 933_CR35
  publication-title: Nat. Rev. Dis. Prim.
  contributor:
    fullname: SG Deeks
– volume: 18
  start-page: 874
  year: 2018
  ident: 933_CR83
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(18)30309-8
  contributor:
    fullname: A Llanos-Cuentas
– volume: 17
  start-page: 192
  year: 2022
  ident: 933_CR169
  publication-title: Curr. Opin. Hiv. AIDS
  doi: 10.1097/COH.0000000000000735
  contributor:
    fullname: C Flexner
– volume: 2
  start-page: 1
  year: 2016
  ident: 933_CR76
  publication-title: Nat. Rev. Dis. Prim.
  contributor:
    fullname: M Pai
– volume: 42
  start-page: 15
  year: 1999
  ident: 933_CR108
  publication-title: Antivir. Res.
  doi: 10.1016/S0166-3542(99)00010-8
  contributor:
    fullname: H Rübsamen-Waigmann
– volume: 25
  start-page: 886
  year: 2021
  ident: 933_CR183
  publication-title: Int. J. Tuberc. Lung Dis.
  doi: 10.5588/ijtld.21.0515
  contributor:
    fullname: MJ Boeree
– volume: 298
  start-page: 210
  year: 2002
  ident: 933_CR22
  publication-title: Science
  doi: 10.1126/science.1074045
  contributor:
    fullname: ABS Sidhu
– volume: 84
  start-page: 9864
  year: 2010
  ident: 933_CR37
  publication-title: J. Virol.
  doi: 10.1128/JVI.00915-10
  contributor:
    fullname: ME Abram
– volume: 387
  start-page: 397
  year: 2022
  ident: 933_CR172
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2203067
  contributor:
    fullname: RL Wu
– volume: 91
  start-page: 7149
  year: 1994
  ident: 933_CR18
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.91.15.7149
  contributor:
    fullname: T Triglia
– volume: 207
  start-page: 1637
  year: 2013
  ident: 933_CR155
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jit077
  contributor:
    fullname: P Sawa
– volume: 11
  year: 2016
  ident: 933_CR88
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0154166
  contributor:
    fullname: AH Lee
– volume: 187
  start-page: 24
  year: 2020
  ident: 933_CR203
  publication-title: Public. Health
  doi: 10.1016/j.puhe.2020.07.031
  contributor:
    fullname: N Obore
– volume: 9
  start-page: 1
  year: 2018
  ident: 933_CR25
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05652-0
  contributor:
    fullname: LS Ross
– ident: 933_CR12
– volume: 44
  start-page: 106
  year: 2011
  ident: 933_CR72
  publication-title: Nat. Genet.
  doi: 10.1038/ng.1038
  contributor:
    fullname: I Comas
– volume: 58
  start-page: 2979
  year: 2014
  ident: 933_CR67
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00037-14
  contributor:
    fullname: RC Hartkoorn
SSID ssj0016172
Score 2.4985187
SecondaryResourceType review_article
Snippet Antimicrobial resistance poses a significant threat to the sustainability of effective treatments against the three most prevalent infectious diseases:...
SourceID proquest
crossref
pubmed
springer
SourceType Aggregation Database
Index Database
Publisher
StartPage 461
SubjectTerms 631/154
692/699/255
Antimicrobial agents
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cancer Research
Drug development
Drug resistance
HIV
Human immunodeficiency virus
Immune system
Infectious diseases
Malaria
Medicinal Chemistry
Molecular Medicine
Pharmacology/Toxicology
Review Article
Tuberculosis
Title Combating antimicrobial resistance in malaria, HIV and tuberculosis
URI https://link.springer.com/article/10.1038/s41573-024-00933-4
https://www.ncbi.nlm.nih.gov/pubmed/38750260
https://www.proquest.com/docview/3064762979
https://www.proquest.com/docview/3055894257
Volume 23
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb5swFLe29LLLtO-xdpMnTb0kZAEMDsembRRNHas0IuWGbDAdUkqmAIf2r9_zR4AondTtgiIH2cjv-fG-fj8Q-uIJj4sJY-C5UQhQSCZsCCMCmzHXzzwn9yhT3RZRsFiSbyt_1WFPFLqk5uP0_kFcyf9IFcZArhIl-w-SbSeFAfgN8oUrSBiuj5IxHGbOag0zrIvbQpEqKab-SrqF8swW5fCWQfSqe2IXEOyplsmGi23arDdVUfXd00jRfBo8SzUeXmybG1nDSWWjZ5t8v2jyXGe6vzNVaJ-t161-_PzFctFr2h62SRxQixaSzcpNmwhoJA2kgZVtJbol6qciXNK1TBnrSSixHaq_-TYWD4wZk6shxka1-vaTaGb2A7uuWdwr8DaoLDvDyjITY_BBeyTa0Y9kvry6SuLLVfwUHUl-RDJAR2fz2Sxqy0vSbVOwM_NsBk0Fq3w9XGPfYzkIQw5K6MoziV-g5yakwGdaP16iJ6J8hU6vNSf53QjHHcSuGuFTfN2xld-9RuetEuE9JcKdEuGixEaJRhhUCG7McF-F3qDl_DI-X9jmyxp2Cu56bdPMoamMhIUfZpnPUzjIIg8YWHBBwYV2ZVgrve9MTMOcOGnK3QlhGc-J8MKp8N6iQbkpxXuECctTP-DU4dyXuQKYI8vdSea5PqMTHlhouNu95LcmUElU44M3TfReJ7DXidrrhFjoZLfBiTloVSKDZHhnhzS00Of2bzCDsrbFSrFp5D2-Pw3lC8hC77Rg2uU8iMkldZ6FRjtJdZP__Vk-PGKxY_SsOwgnaFBvG_ERvNSafzI69wcqeI6A
link.rule.ids 314,780,784,27924,27925
linkProvider Library Specific Holdings
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Combating+antimicrobial+resistance+in+malaria%2C+HIV+and+tuberculosis&rft.jtitle=Nature+reviews.+Drug+discovery&rft.au=Duffey%2C+Ma%C3%ABlle&rft.au=Shafer%2C+Robert+W&rft.au=Timm%2C+Juliano&rft.au=Burrows%2C+Jeremy+N&rft.date=2024-06-01&rft.issn=1474-1784&rft.eissn=1474-1784&rft.volume=23&rft.issue=6&rft.spage=461&rft_id=info:doi/10.1038%2Fs41573-024-00933-4&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1474-1776&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1474-1776&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1474-1776&client=summon