Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in gastrointestinal cancers - Wu, Ziming; Dai, Jie; Li, Jie; Zhang, Zhengyu; Shen, Xbing (Naunyn-Schmiedeberg's archives of pharmacology, 2025)
Keywords: Animals; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer therapies; Chemotherapy; Colorectal carcinoma; DNA damage; DNA Methylation; DNA methyltransferase; DNA Modification Methylases - genetics; DNA Modification Methylases - metabolism; DNA repair; DNA Repair Enzymes - genetics; DNA Repair Enzymes - metabolism; Drug development; Gastrointestinal Neoplasms - drug therapy; Gastrointestinal Neoplasms - enzymology; Gastrointestinal Neoplasms - genetics; Humans; Methylguanine; Neurosciences; O-Methylguanine-DNA Methyltransferase - genetics; O-Methylguanine-DNA Methyltransferase - metabolism; O6-methylguanine-DNA methyltransferase; Pharmacology/Toxicology; Review; Structure-function relationships; Temozolomide; Tumor Suppressor Proteins - chemistry; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Methylation; MGMT; Gastrointestinal cancer; Gastric cancer; Colorectal cancer