Association between the triglyceride-glucose index and thyroid disorders: a cross-sectional survey and Mendelian randomization analysis
Background Metabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the relationship between the triglyceride-glucose (TyG) index, a simple insulin-resistance marker, and thyroid disorders. Methods Eligible TIDE...
Saved in:
Published in | Endocrine Vol. 86; no. 1; pp. 173 - 185 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.10.2024
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background
Metabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the relationship between the triglyceride-glucose (TyG) index, a simple insulin-resistance marker, and thyroid disorders.
Methods
Eligible TIDE (Thyroid Diseases, Iodine Status and Diabetes Epidemiology) subjects (n = 47,710) were screened with inclusion/exclusion criteria. Thyroid disorder prevalence among different TyG index groups was stratified by sex. Logistic regression evaluated the correlation between the TyG index and thyroid disorders. Multiple linear regression evaluated the association between the TyG index and TSH. Additionally, two-sample Mendelian randomization (MR) using published genome-wide association study data evaluated causality in the association between the TyG index and TSH.
Results
Men and women with greater TyG indices had a significantly greater prevalence of thyroid disorders than individuals with the lowest quartile (Q1) of TyG index (
p
< 0.05). Following adjustment for confounding factors, we observed that a greater TyG index significantly increased the risk of subclinical hypothyroidism in men and women (men: Q2: odds ratio (OR) [95% confidence interval (CI)] = 1.22 [1.07–1.38],
p
= 0.002; Q3: OR [95% CI] = 1.28 [1.12–1.45],
p
< 0.001; Q4: OR [95% CI] = 1.29 [1.12–1.50],
p
= 0.001; women: Q2: OR [95% CI] = 1.25 [1.12–1.39],
p
< 0.001; Q3: OR [95% CI] = 1.47 [1.31–1.64],
p
< 0.001; Q4: OR [95% CI] = 1.61 [1.43–1.82],
p
< 0.001). Only among women was the highest TyG index quartile associated with hypothyroidism (OR [95% CI] = 1.70 [1.15–2.50],
p
= 0.007). Additionally, in men, the association exists only in the more than adequate iodine intake population. In women, the relationship between the TyG index and thyroid disorders disappears after menopause. Furthermore, the TyG index exhibited a linear positive correlation with TSH levels. The MR analysis results revealed a causal relationship between a genetically determined greater TyG index and increased TSH (inverse-variance weighting (IVW): OR [95% CI] = 1.14 [1.02–1.28],
p
= 0.020); however, this causal relationship disappeared after adjusting for BMI in multivariable MR (MVMR) analysis (MVMR-IVW: OR 1.03, 95% CI 0.87–1.22,
p
= 0.739).
Conclusions
A greater TyG index is associated with hypothyroidism and subclinical hypothyroidism and varies by sex and menopausal status. MR analysis demonstrated that the causal relationship between a genetically determined greater TyG index and elevated TSH levels is confounded or mediated by BMI. |
---|---|
AbstractList | Metabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the relationship between the triglyceride-glucose (TyG) index, a simple insulin-resistance marker, and thyroid disorders.
Eligible TIDE (Thyroid Diseases, Iodine Status and Diabetes Epidemiology) subjects (n = 47,710) were screened with inclusion/exclusion criteria. Thyroid disorder prevalence among different TyG index groups was stratified by sex. Logistic regression evaluated the correlation between the TyG index and thyroid disorders. Multiple linear regression evaluated the association between the TyG index and TSH. Additionally, two-sample Mendelian randomization (MR) using published genome-wide association study data evaluated causality in the association between the TyG index and TSH.
Men and women with greater TyG indices had a significantly greater prevalence of thyroid disorders than individuals with the lowest quartile (Q1) of TyG index (p < 0.05). Following adjustment for confounding factors, we observed that a greater TyG index significantly increased the risk of subclinical hypothyroidism in men and women (men: Q2: odds ratio (OR) [95% confidence interval (CI)] = 1.22 [1.07-1.38], p = 0.002; Q3: OR [95% CI] = 1.28 [1.12-1.45], p < 0.001; Q4: OR [95% CI] = 1.29 [1.12-1.50], p = 0.001; women: Q2: OR [95% CI] = 1.25 [1.12-1.39], p < 0.001; Q3: OR [95% CI] = 1.47 [1.31-1.64], p < 0.001; Q4: OR [95% CI] = 1.61 [1.43-1.82], p < 0.001). Only among women was the highest TyG index quartile associated with hypothyroidism (OR [95% CI] = 1.70 [1.15-2.50], p = 0.007). Additionally, in men, the association exists only in the more than adequate iodine intake population. In women, the relationship between the TyG index and thyroid disorders disappears after menopause. Furthermore, the TyG index exhibited a linear positive correlation with TSH levels. The MR analysis results revealed a causal relationship between a genetically determined greater TyG index and increased TSH (inverse-variance weighting (IVW): OR [95% CI] = 1.14 [1.02-1.28], p = 0.020); however, this causal relationship disappeared after adjusting for BMI in multivariable MR (MVMR) analysis (MVMR-IVW: OR 1.03, 95% CI 0.87-1.22, p = 0.739).
A greater TyG index is associated with hypothyroidism and subclinical hypothyroidism and varies by sex and menopausal status. MR analysis demonstrated that the causal relationship between a genetically determined greater TyG index and elevated TSH levels is confounded or mediated by BMI. BackgroundMetabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the relationship between the triglyceride-glucose (TyG) index, a simple insulin-resistance marker, and thyroid disorders.MethodsEligible TIDE (Thyroid Diseases, Iodine Status and Diabetes Epidemiology) subjects (n = 47,710) were screened with inclusion/exclusion criteria. Thyroid disorder prevalence among different TyG index groups was stratified by sex. Logistic regression evaluated the correlation between the TyG index and thyroid disorders. Multiple linear regression evaluated the association between the TyG index and TSH. Additionally, two-sample Mendelian randomization (MR) using published genome-wide association study data evaluated causality in the association between the TyG index and TSH.ResultsMen and women with greater TyG indices had a significantly greater prevalence of thyroid disorders than individuals with the lowest quartile (Q1) of TyG index (p < 0.05). Following adjustment for confounding factors, we observed that a greater TyG index significantly increased the risk of subclinical hypothyroidism in men and women (men: Q2: odds ratio (OR) [95% confidence interval (CI)] = 1.22 [1.07–1.38], p = 0.002; Q3: OR [95% CI] = 1.28 [1.12–1.45], p < 0.001; Q4: OR [95% CI] = 1.29 [1.12–1.50], p = 0.001; women: Q2: OR [95% CI] = 1.25 [1.12–1.39], p < 0.001; Q3: OR [95% CI] = 1.47 [1.31–1.64], p < 0.001; Q4: OR [95% CI] = 1.61 [1.43–1.82], p < 0.001). Only among women was the highest TyG index quartile associated with hypothyroidism (OR [95% CI] = 1.70 [1.15–2.50], p = 0.007). Additionally, in men, the association exists only in the more than adequate iodine intake population. In women, the relationship between the TyG index and thyroid disorders disappears after menopause. Furthermore, the TyG index exhibited a linear positive correlation with TSH levels. The MR analysis results revealed a causal relationship between a genetically determined greater TyG index and increased TSH (inverse-variance weighting (IVW): OR [95% CI] = 1.14 [1.02–1.28], p = 0.020); however, this causal relationship disappeared after adjusting for BMI in multivariable MR (MVMR) analysis (MVMR-IVW: OR 1.03, 95% CI 0.87–1.22, p = 0.739).ConclusionsA greater TyG index is associated with hypothyroidism and subclinical hypothyroidism and varies by sex and menopausal status. MR analysis demonstrated that the causal relationship between a genetically determined greater TyG index and elevated TSH levels is confounded or mediated by BMI. Metabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the relationship between the triglyceride-glucose (TyG) index, a simple insulin-resistance marker, and thyroid disorders.BACKGROUNDMetabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the relationship between the triglyceride-glucose (TyG) index, a simple insulin-resistance marker, and thyroid disorders.Eligible TIDE (Thyroid Diseases, Iodine Status and Diabetes Epidemiology) subjects (n = 47,710) were screened with inclusion/exclusion criteria. Thyroid disorder prevalence among different TyG index groups was stratified by sex. Logistic regression evaluated the correlation between the TyG index and thyroid disorders. Multiple linear regression evaluated the association between the TyG index and TSH. Additionally, two-sample Mendelian randomization (MR) using published genome-wide association study data evaluated causality in the association between the TyG index and TSH.METHODSEligible TIDE (Thyroid Diseases, Iodine Status and Diabetes Epidemiology) subjects (n = 47,710) were screened with inclusion/exclusion criteria. Thyroid disorder prevalence among different TyG index groups was stratified by sex. Logistic regression evaluated the correlation between the TyG index and thyroid disorders. Multiple linear regression evaluated the association between the TyG index and TSH. Additionally, two-sample Mendelian randomization (MR) using published genome-wide association study data evaluated causality in the association between the TyG index and TSH.Men and women with greater TyG indices had a significantly greater prevalence of thyroid disorders than individuals with the lowest quartile (Q1) of TyG index (p < 0.05). Following adjustment for confounding factors, we observed that a greater TyG index significantly increased the risk of subclinical hypothyroidism in men and women (men: Q2: odds ratio (OR) [95% confidence interval (CI)] = 1.22 [1.07-1.38], p = 0.002; Q3: OR [95% CI] = 1.28 [1.12-1.45], p < 0.001; Q4: OR [95% CI] = 1.29 [1.12-1.50], p = 0.001; women: Q2: OR [95% CI] = 1.25 [1.12-1.39], p < 0.001; Q3: OR [95% CI] = 1.47 [1.31-1.64], p < 0.001; Q4: OR [95% CI] = 1.61 [1.43-1.82], p < 0.001). Only among women was the highest TyG index quartile associated with hypothyroidism (OR [95% CI] = 1.70 [1.15-2.50], p = 0.007). Additionally, in men, the association exists only in the more than adequate iodine intake population. In women, the relationship between the TyG index and thyroid disorders disappears after menopause. Furthermore, the TyG index exhibited a linear positive correlation with TSH levels. The MR analysis results revealed a causal relationship between a genetically determined greater TyG index and increased TSH (inverse-variance weighting (IVW): OR [95% CI] = 1.14 [1.02-1.28], p = 0.020); however, this causal relationship disappeared after adjusting for BMI in multivariable MR (MVMR) analysis (MVMR-IVW: OR 1.03, 95% CI 0.87-1.22, p = 0.739).RESULTSMen and women with greater TyG indices had a significantly greater prevalence of thyroid disorders than individuals with the lowest quartile (Q1) of TyG index (p < 0.05). Following adjustment for confounding factors, we observed that a greater TyG index significantly increased the risk of subclinical hypothyroidism in men and women (men: Q2: odds ratio (OR) [95% confidence interval (CI)] = 1.22 [1.07-1.38], p = 0.002; Q3: OR [95% CI] = 1.28 [1.12-1.45], p < 0.001; Q4: OR [95% CI] = 1.29 [1.12-1.50], p = 0.001; women: Q2: OR [95% CI] = 1.25 [1.12-1.39], p < 0.001; Q3: OR [95% CI] = 1.47 [1.31-1.64], p < 0.001; Q4: OR [95% CI] = 1.61 [1.43-1.82], p < 0.001). Only among women was the highest TyG index quartile associated with hypothyroidism (OR [95% CI] = 1.70 [1.15-2.50], p = 0.007). Additionally, in men, the association exists only in the more than adequate iodine intake population. In women, the relationship between the TyG index and thyroid disorders disappears after menopause. Furthermore, the TyG index exhibited a linear positive correlation with TSH levels. The MR analysis results revealed a causal relationship between a genetically determined greater TyG index and increased TSH (inverse-variance weighting (IVW): OR [95% CI] = 1.14 [1.02-1.28], p = 0.020); however, this causal relationship disappeared after adjusting for BMI in multivariable MR (MVMR) analysis (MVMR-IVW: OR 1.03, 95% CI 0.87-1.22, p = 0.739).A greater TyG index is associated with hypothyroidism and subclinical hypothyroidism and varies by sex and menopausal status. MR analysis demonstrated that the causal relationship between a genetically determined greater TyG index and elevated TSH levels is confounded or mediated by BMI.CONCLUSIONSA greater TyG index is associated with hypothyroidism and subclinical hypothyroidism and varies by sex and menopausal status. MR analysis demonstrated that the causal relationship between a genetically determined greater TyG index and elevated TSH levels is confounded or mediated by BMI. Background Metabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the relationship between the triglyceride-glucose (TyG) index, a simple insulin-resistance marker, and thyroid disorders. Methods Eligible TIDE (Thyroid Diseases, Iodine Status and Diabetes Epidemiology) subjects (n = 47,710) were screened with inclusion/exclusion criteria. Thyroid disorder prevalence among different TyG index groups was stratified by sex. Logistic regression evaluated the correlation between the TyG index and thyroid disorders. Multiple linear regression evaluated the association between the TyG index and TSH. Additionally, two-sample Mendelian randomization (MR) using published genome-wide association study data evaluated causality in the association between the TyG index and TSH. Results Men and women with greater TyG indices had a significantly greater prevalence of thyroid disorders than individuals with the lowest quartile (Q1) of TyG index ( p < 0.05). Following adjustment for confounding factors, we observed that a greater TyG index significantly increased the risk of subclinical hypothyroidism in men and women (men: Q2: odds ratio (OR) [95% confidence interval (CI)] = 1.22 [1.07–1.38], p = 0.002; Q3: OR [95% CI] = 1.28 [1.12–1.45], p < 0.001; Q4: OR [95% CI] = 1.29 [1.12–1.50], p = 0.001; women: Q2: OR [95% CI] = 1.25 [1.12–1.39], p < 0.001; Q3: OR [95% CI] = 1.47 [1.31–1.64], p < 0.001; Q4: OR [95% CI] = 1.61 [1.43–1.82], p < 0.001). Only among women was the highest TyG index quartile associated with hypothyroidism (OR [95% CI] = 1.70 [1.15–2.50], p = 0.007). Additionally, in men, the association exists only in the more than adequate iodine intake population. In women, the relationship between the TyG index and thyroid disorders disappears after menopause. Furthermore, the TyG index exhibited a linear positive correlation with TSH levels. The MR analysis results revealed a causal relationship between a genetically determined greater TyG index and increased TSH (inverse-variance weighting (IVW): OR [95% CI] = 1.14 [1.02–1.28], p = 0.020); however, this causal relationship disappeared after adjusting for BMI in multivariable MR (MVMR) analysis (MVMR-IVW: OR 1.03, 95% CI 0.87–1.22, p = 0.739). Conclusions A greater TyG index is associated with hypothyroidism and subclinical hypothyroidism and varies by sex and menopausal status. MR analysis demonstrated that the causal relationship between a genetically determined greater TyG index and elevated TSH levels is confounded or mediated by BMI. |
Author | Wang, Chuyuan Li, Yongze Wang, Haoyu Lai, Yaxin Han, Yutong Gao, Xiaotong Wang, Xichang Zhang, Chenyu Teng, Weiping Shan, Zhongyan |
Author_xml | – sequence: 1 givenname: Chenyu surname: Zhang fullname: Zhang, Chenyu organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University – sequence: 2 givenname: Haoyu surname: Wang fullname: Wang, Haoyu organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University – sequence: 3 givenname: Yongze surname: Li fullname: Li, Yongze organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University – sequence: 4 givenname: Xichang surname: Wang fullname: Wang, Xichang organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University – sequence: 5 givenname: Yutong surname: Han fullname: Han, Yutong organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University – sequence: 6 givenname: Xiaotong surname: Gao fullname: Gao, Xiaotong organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University – sequence: 7 givenname: Yaxin surname: Lai fullname: Lai, Yaxin organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University – sequence: 8 givenname: Chuyuan surname: Wang fullname: Wang, Chuyuan organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University – sequence: 9 givenname: Weiping surname: Teng fullname: Teng, Weiping organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University – sequence: 10 givenname: Zhongyan orcidid: 0000-0002-2849-2380 surname: Shan fullname: Shan, Zhongyan email: cmushanzhongyan@163.com organization: Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38782862$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kctu1TAQhi1URC_wAiyQJTZsDGP7xEnYVRU3qYgNrCPHnhxc5djFkxTSF-hr43NSLmLBamY03_wz9n_KjmKKyNhTCS8lQP2KpAIFAtRGgG6qRlQP2ImsqlZA6R_9lR-zU6IrAKWUqR-xY93UjWqMOmF350TJBTuFFHmP03fEyKevyKcctuPiMAePYjvOLhHyED3-4Db6giw5Bc99oJQ9ZnrNLXc5EQlCt1ezI6c53-By4D9iGR2DjTyXMu3C7brSFm6hQI_Zw8GOhE_u4xn78vbN54v34vLTuw8X55fCaWUmYTzUrakkoJHOgem17GXdb7w2ld9ogKbd9I0brNaVtm1d66GvWpAaBu1Lqs_Yi1X3OqdvM9LU7QI5HEcbMc3UaTCg60qqtqDP_0Gv0pzLvYWSUpVvlVoXSq3U4fEZh-46h53NSyeh29vUrTZ1xabuYFO3v-LZvfTc79D_HvnlSwH0ClBpxS3mP7v_I_sTiJGg1A |
Cites_doi | 10.1016/j.jhep.2014.06.037 10.1210/jc.2005-0799 10.1016/j.dsx.2020.11.008 10.1002/hep.23800 10.3904/kjim.2013.28.2.180 10.1038/s41598-021-01101-z 10.1007/s12291-010-0026-x 10.2337/dc18-1410 10.1016/j.jdiacomp.2017.10.007 10.1001/jama.2017.8981 10.1093/hmg/ddy327 10.1530/ETJ-21-0063 10.2337/dc18-1920 10.3389/fendo.2021.661160 10.1089/thy.2019.0067 10.1186/1475-2840-10-93 10.1016/j.numecd.2020.06.019 10.1155/2019/5121574 10.1136/bmj.m997 10.1007/s10654-015-0011-z 10.1007/978-3-319-48382-5_12 10.3904/kjim.2011.26.4.432 10.1016/j.maturitas.2009.01.007 10.1371/journal.pgen.1007081 10.1210/er.2002-0010 10.1507/endocrj.EJ12-0462 10.1186/s12933-014-0146-3 10.1152/ajpendo.00194.2018 10.1016/j.numecd.2015.09.007 10.1111/j.1365-2265.2009.03698.x 10.1194/jlr.M047654 10.1186/s12944-021-01561-2 10.1016/j.arcmed.2016.08.012 10.1210/clinem/dgab183 10.1089/met.2008.0034 10.1016/j.pcl.2005.07.009 10.1093/ije/dyg070 10.1186/s12933-021-01391-7 10.1371/journal.pone.0254630 10.1111/cen.13823 10.1186/s12916-016-0693-4 10.1007/BF03346663 10.1371/journal.pone.0125922 10.1007/s10495-009-0352-8 10.1056/NEJM199312303292703 10.3389/fcvm.2020.583473 10.3390/ijms19103284 10.12688/wellcomeopenres.19995.2 10.1155/2018/4215848 10.1089/met.2015.0045 10.1210/jc.2010-0288 10.1111/j.1365-2265.2011.04058.x 10.1155/2020/3240198 10.1530/EJE-08-0797 10.1089/thy.2018.0018 10.1038/s41588-018-0099-7 10.1371/journal.pone.0163465 10.1016/j.diabet.2015.04.004 10.1113/JP276747 |
ContentType | Journal Article |
Copyright | The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1007/s12020-024-03858-5 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
EISSN | 1559-0100 |
EndPage | 185 |
ExternalDocumentID | 10_1007_s12020_024_03858_5 38782862 |
Genre | Journal Article |
GrantInformation_xml | – fundername: the Key Laboratory Project of Thyroid Diseases, National Health Commission grantid: 2019PT330001 – fundername: the National Natural Science Foundation of China grantid: 81970682 – fundername: he National Natural Science Foundation of China grantid: U1508219 |
GroupedDBID | --- -53 -5E -5G -BR -EM -Y2 -~C .86 .GJ .VR 06C 06D 0R~ 0VY 2.D 203 28- 29G 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2VQ 2~H 30V 4.4 406 408 40E 53G 5GY 5VS 78A 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAEOY AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO ABAKF ABDZT ABECU ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKCH ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTKH ABTMW ABWNU ABXPI ACAOD ACCUX ACDTI ACGFO ACGFS ACHSB ACHXU ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACREN ACSNA ACUDM ACZOJ ADHHG ADHIR ADINQ ADJJI ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYOE ADZKW AEBTG AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFLOW AFQWF AFWTZ AFYQB AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHSBF AI. AIAGR AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJOOF AJRNO AJZVZ AKMHD ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMTXH AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBWZM BDATZ BGNMA CAG COF CS3 CSCUP DDRTE DNIVK DPUIP EBD EBLON EBS EIOEI EJD EMOBN ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GRRUI H13 HF~ HG6 HMJXF HRMNR HVGLF HZ~ IJ- IKXTQ IMOTQ IWAJR IXD I~X I~Z J-C J0Z JBSCW JZLTJ KOV LLZTM M4Y MA- N2Q N9A NDZJH NF0 NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OVD P19 P2P P9S PF0 PT4 PT5 QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RSV RZK S16 S1Z S26 S27 S28 S37 S3B SAP SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TEORI TSG TT1 TUC U2A U9L UG4 UOJIU UTJUX UZXMN VC2 VFIZW VH1 W48 WK8 YLTOR Z7U Z82 Z83 Z87 Z8O Z8V Z91 ZMTXR ZOVNA ZXP ~A9 ~EX ~KM AAYZH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c326t-6d0796510e61cc06b31b17b4d365d4300894b8cfa3353a9773fb590130f3dfb53 |
IEDL.DBID | AGYKE |
ISSN | 1559-0100 1355-008X |
IngestDate | Tue Oct 01 16:30:56 EDT 2024 Thu Oct 10 20:59:57 EDT 2024 Wed Oct 02 14:40:06 EDT 2024 Fri Oct 18 09:22:10 EDT 2024 Wed Oct 02 01:26:43 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | TSH Mendelian randomization Thyroid function Subclinical hypothyroidism TyG index |
Language | English |
License | 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c326t-6d0796510e61cc06b31b17b4d365d4300894b8cfa3353a9773fb590130f3dfb53 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-2849-2380 |
PMID | 38782862 |
PQID | 3112100133 |
PQPubID | 2043848 |
PageCount | 13 |
ParticipantIDs | proquest_miscellaneous_3060375129 proquest_journals_3112100133 crossref_primary_10_1007_s12020_024_03858_5 pubmed_primary_38782862 springer_journals_10_1007_s12020_024_03858_5 |
PublicationCentury | 2000 |
PublicationDate | 2024-10-01 |
PublicationDateYYYYMMDD | 2024-10-01 |
PublicationDate_xml | – month: 10 year: 2024 text: 2024-10-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | New York |
PublicationPlace_xml | – name: New York – name: United States |
PublicationSubtitle | International Journal of Basic and Clinical Endocrinology |
PublicationTitle | Endocrine |
PublicationTitleAbbrev | Endocrine |
PublicationTitleAlternate | Endocrine |
PublicationYear | 2024 |
Publisher | Springer US Springer Nature B.V |
Publisher_xml | – name: Springer US – name: Springer Nature B.V |
References | Ruhla, Weickert, Arafat, Osterhoff, Isken, Spranger (CR33) 2010; 72 Saely, Aczel, Marte, Langer, Hoefle, Drexel (CR3) 2005; 90 Wang, Gao, Han, Zhang, Lin, Wang (CR19) 2021; 106 Oh, Sung, Lee (CR32) 2013; 28 Hu, Zhao, Luo, Yu, Shao, Zhao (CR51) 2020; 2020 Ziros, Habeos, Chartoumpekis, Ntalampyra, Somm, Renaud (CR53) 2018; 28 Lee, Kim, Oh, Park, Kim, Park (CR31) 2011; 26 Kocatürk, Kar, Küskü Kiraz, Alataş (CR41) 2020; 14 Yan, Wang, Lu, Chen, Song, Jing (CR38) 2014; 61 Du, Yuan, Zhang, Zhou, Sun, Yu (CR8) 2014; 13 Spira, Buchmann, Dörr, Markus, Nauck, Schipf (CR43) 2022; 11 Zhang, Shao, Zhao, Yang, Zhao, Fang (CR54) 2019; 316 Fernández-Real, Ricart (CR2) 2003; 24 Smith, Ebrahim (CR14) 2003; 32 Larsson, Burgess, Michaëlsson (CR15) 2017; 318 Chaker, Ligthart, Korevaar, Hofman, Franco, Peeters (CR34) 2016; 14 Amouzegar, Kazemian, Gharibzadeh, Mehran, Tohidi, Azizi (CR58) 2015; 41 Lillioja, Mott, Spraul, Ferraro, Foley, Ravussin (CR10) 1993; 329 Mazidi, Kengne, Katsiki, Mikhailidis, Banach (CR6) 2018; 32 Li, Teng, Ba, Chen, Du, He (CR24) 2020; 30 Singh, Goswami, Mallika (CR47) 2010; 25 He, Lai, Yang, Yao, Li, Teng (CR9) 2021; 12 Patel, Ye, Xue, Lin, Xu, Woolf (CR22) 2023; 8 Liu, Wu, Xu, Sha, Xu, Kang (CR12) 2020; 30 Tian, Song, Xing, Zhang, Ning, Li (CR36) 2010; 52 Simental-Mendía, Rodríguez-Morán, Guerrero-Romero (CR4) 2008; 6 Lu, Chang, Chou, Tsai, Liu, Chen (CR28) 2021; 20 Choi, Kim, Kwak, Kim, Hong (CR40) 2021; 11 Maratou, Hadjidakis, Kollias, Tsegka, Peppa, Alevizaki (CR46) 2009; 160 Zhang, Song, Feng, Zhou, Lu, Gao (CR37) 2015; 56 Benseñor, Goulart, Molina Mdel, de Miranda, Santos, Lotufo (CR42) 2015; 13 Zhao, Zhang, Gao, Song, Xu, Yu (CR52) 2018; 2018 Guerrero-Romero, Villalobos-Molina, Jiménez-Flores, Simental-Mendia, Méndez-Cruz, Murguía-Romero (CR5) 2016; 47 Kitae, Hashimoto, Hamaguchi, Obora, Kojima, Fukui (CR27) 2019; 2019 Krysiak, Okopien (CR56) 2011; 75 Burgess, Scott, Timpson, Davey Smith, Thompson (CR17) 2015; 30 Singh, Sinha, Yen (CR59) 2018; 19 Kwon, Cho, Lee, Park, Park, Lee (CR44) 2018; 89 Wang, Xu, Bo, Zhou, Jiang, Gao (CR35) 2013; 60 Si, Li, Li, Li, Chen, Yuan (CR18) 2020; 7 Lee, Lee, Kim, Park, Park, Oh (CR26) 2016; 11 Sheng, Lu, Xie, Peng, Kuang, Zou (CR29) 2021; 20 Guerrero-Romero, Simental-Mendía, González-Ortiz, Martínez-Abundis, Ramos-Zavala, Hernández-González (CR25) 2010; 95 Nakamura, Sadoshima (CR50) 2020; 598 Gungor, Hannon, Libman, Bacha, Arslanian (CR1) 2005; 52 Chiang, Lai, Chang, Koo (CR7) 2011; 10 Park, Ahn, Lee, Kang, Nam, Lee (CR11) 2019; 42 Pulit, Stoneman, Morris, Wood, Glastonbury, Tyrrell (CR20) 2019; 28 Kusminski, Shetty, Orci, Unger, Scherer (CR49) 2009; 14 Laclaustra, Hurtado-Roca, Sendin, Leon, Ledesma, Andres (CR57) 2015; 25 Park, Cho, Ahn, Shin, Hong, Kim (CR30) 2009; 62 Ambrosi, Masserini, Iorio, Delnevo, Malavazos, Morricone (CR13) 2010; 33 Choi, Park, Hong, Yoon, Kim, Kang (CR39) 2021; 16 Yang, Yao, Miao, Liu, Gao, Fan (CR45) 2015; 10 Yazıcı, Sezer (CR48) 2017; 960 Li, Teng, Shi, Qin, Qin, Quan (CR16) 2020; 369 Laclaustra, Moreno-Franco, Lou-Bonafonte, Mateo-Gallego, Casasnovas, Guallar-Castillon (CR55) 2019; 42 Verbanck, Chen, Neale, Do (CR23) 2018; 50 Hemani, Tilling, Davey Smith (CR21) 2017; 13 G Hemani (3858_CR21) 2017; 13 Y Li (3858_CR16) 2020; 369 SL Pulit (3858_CR20) 2019; 28 A Patel (3858_CR22) 2023; 8 YM Choi (3858_CR40) 2021; 11 S Si (3858_CR18) 2020; 7 JK Chiang (3858_CR7) 2011; 10 J He (3858_CR9) 2021; 12 K Park (3858_CR11) 2019; 42 G Sheng (3858_CR29) 2021; 20 D Spira (3858_CR43) 2022; 11 S Lillioja (3858_CR10) 1993; 329 CH Saely (3858_CR3) 2005; 90 LE Simental-Mendía (3858_CR4) 2008; 6 W Choi (3858_CR39) 2021; 16 BM Singh (3858_CR47) 2010; 25 T Wang (3858_CR35) 2013; 60 X Zhang (3858_CR37) 2015; 56 N Yang (3858_CR45) 2015; 10 B Hu (3858_CR51) 2020; 2020 DY Lee (3858_CR26) 2016; 11 T Du (3858_CR8) 2014; 13 E Maratou (3858_CR46) 2009; 160 F Yan (3858_CR38) 2014; 61 GD Smith (3858_CR14) 2003; 32 JY Oh (3858_CR32) 2013; 28 M Nakamura (3858_CR50) 2020; 598 Y Li (3858_CR24) 2020; 30 M Verbanck (3858_CR23) 2018; 50 H Kwon (3858_CR44) 2018; 89 BK Singh (3858_CR59) 2018; 19 YK Lee (3858_CR31) 2011; 26 N Gungor (3858_CR1) 2005; 52 JM Fernández-Real (3858_CR2) 2003; 24 A Kitae (3858_CR27) 2019; 2019 CM Kusminski (3858_CR49) 2009; 14 F Guerrero-Romero (3858_CR5) 2016; 47 X Wang (3858_CR19) 2021; 106 YW Lu (3858_CR28) 2021; 20 B Ambrosi (3858_CR13) 2010; 33 M Laclaustra (3858_CR57) 2015; 25 A Amouzegar (3858_CR58) 2015; 41 IM Benseñor (3858_CR42) 2015; 13 PG Ziros (3858_CR53) 2018; 28 L Tian (3858_CR36) 2010; 52 D Yazıcı (3858_CR48) 2017; 960 S Ruhla (3858_CR33) 2010; 72 L Chaker (3858_CR34) 2016; 14 SC Larsson (3858_CR15) 2017; 318 F Guerrero-Romero (3858_CR25) 2010; 95 M Mazidi (3858_CR6) 2018; 32 S Burgess (3858_CR17) 2015; 30 M Zhao (3858_CR52) 2018; 2018 E Kocatürk (3858_CR41) 2020; 14 Y Liu (3858_CR12) 2020; 30 R Krysiak (3858_CR56) 2011; 75 HT Park (3858_CR30) 2009; 62 X Zhang (3858_CR54) 2019; 316 M Laclaustra (3858_CR55) 2019; 42 |
References_xml | – volume: 61 start-page: 1358 issue: 6 year: 2014 end-page: 1364 ident: CR38 article-title: Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity publication-title: J. Hepatol. doi: 10.1016/j.jhep.2014.06.037 contributor: fullname: Jing – volume: 90 start-page: 5698 issue: 10 year: 2005 end-page: 5703 ident: CR3 article-title: The metabolic syndrome, insulin resistance, and cardiovascular risk in diabetic and nondiabetic patients publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2005-0799 contributor: fullname: Drexel – volume: 14 start-page: 2147 issue: 6 year: 2020 end-page: 2151 ident: CR41 article-title: Insulin resistance and pancreatic β cell dysfunction are associated with thyroid hormone functions: a cross-sectional hospital-based study in Turkey publication-title: Diabetes Metab. Syndr. doi: 10.1016/j.dsx.2020.11.008 contributor: fullname: Alataş – volume: 52 start-page: 1401 issue: 4 year: 2010 end-page: 1409 ident: CR36 article-title: A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway publication-title: Hepatology doi: 10.1002/hep.23800 contributor: fullname: Li – volume: 28 start-page: 180 issue: 2 year: 2013 end-page: 186 ident: CR32 article-title: Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in euthyroid young women publication-title: Korean J. Intern. Med. doi: 10.3904/kjim.2013.28.2.180 contributor: fullname: Lee – volume: 11 issue: 1 year: 2021 ident: CR40 article-title: Association between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey publication-title: Sci. Rep. doi: 10.1038/s41598-021-01101-z contributor: fullname: Hong – volume: 25 start-page: 141 issue: 2 year: 2010 end-page: 145 ident: CR47 article-title: Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital publication-title: Indian J. Clin. Biochem. doi: 10.1007/s12291-010-0026-x contributor: fullname: Mallika – volume: 42 start-page: 303 issue: 2 year: 2019 end-page: 310 ident: CR55 article-title: Impaired sensitivity to thyroid hormones is associated with diabetes and metabolic syndrome publication-title: Diabetes Care doi: 10.2337/dc18-1410 contributor: fullname: Guallar-Castillon – volume: 32 start-page: 266 issue: 3 year: 2018 end-page: 270 ident: CR6 article-title: Lipid accumulation product and triglycerides/glucose index are useful predictors of insulin resistance publication-title: J. Diabetes Complic. doi: 10.1016/j.jdiacomp.2017.10.007 contributor: fullname: Banach – volume: 318 start-page: 371 issue: 4 year: 2017 end-page: 380 ident: CR15 article-title: Association of genetic variants related to serum calcium levels with coronary artery disease and myocardial infarction publication-title: JAMA doi: 10.1001/jama.2017.8981 contributor: fullname: Michaëlsson – volume: 28 start-page: 166 issue: 1 year: 2019 end-page: 174 ident: CR20 article-title: Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddy327 contributor: fullname: Tyrrell – volume: 11 start-page: e10063 issue: 2 year: 2022 ident: CR43 article-title: Association of thyroid function with insulin resistance: data from two population-based studies publication-title: Eur. Thyroid J. doi: 10.1530/ETJ-21-0063 contributor: fullname: Schipf – volume: 42 start-page: 1569 issue: 8 year: 2019 end-page: 1573 ident: CR11 article-title: Elevated TyG index predicts progression of coronary artery calcification publication-title: Diabetes Care doi: 10.2337/dc18-1920 contributor: fullname: Lee – volume: 12 year: 2021 ident: CR9 article-title: The relationship between thyroid function and metabolic syndrome and its components: a cross-sectional study in a Chinese population publication-title: Front. Endocrinol. doi: 10.3389/fendo.2021.661160 contributor: fullname: Teng – volume: 30 start-page: 568 issue: 4 year: 2020 end-page: 579 ident: CR24 article-title: Efficacy and safety of long-term universal salt iodization on thyroid disorders: epidemiological evidence from 31 provinces of mainland China publication-title: Thyroid doi: 10.1089/thy.2019.0067 contributor: fullname: He – volume: 10 start-page: 93 year: 2011 ident: CR7 article-title: Predicting insulin resistance using the triglyceride-to-high-density lipoprotein cholesterol ratio in Taiwanese adults publication-title: Cardiovasc. Diabetol. doi: 10.1186/1475-2840-10-93 contributor: fullname: Koo – volume: 30 start-page: 2072 issue: 11 year: 2020 end-page: 2076 ident: CR12 article-title: Association between triglyceride and glycose (TyG) index and subclinical myocardial injury publication-title: Nutr. Metab. Cardiovasc. Dis. doi: 10.1016/j.numecd.2020.06.019 contributor: fullname: Kang – volume: 2019 year: 2019 ident: CR27 article-title: The triglyceride and glucose index is a predictor of incident nonalcoholic fatty liver disease: a population-based cohort study publication-title: Can. J. Gastroenterol. Hepatol. doi: 10.1155/2019/5121574 contributor: fullname: Fukui – volume: 369 start-page: m997 year: 2020 ident: CR16 article-title: Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross-sectional study publication-title: BMJ doi: 10.1136/bmj.m997 contributor: fullname: Quan – volume: 30 start-page: 543 issue: 7 year: 2015 end-page: 552 ident: CR17 article-title: Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors publication-title: Eur. J. Epidemiol. doi: 10.1007/s10654-015-0011-z contributor: fullname: Thompson – volume: 960 start-page: 277 year: 2017 end-page: 304 ident: CR48 article-title: Insulin resistance, obesity and lipotoxicity publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-3-319-48382-5_12 contributor: fullname: Sezer – volume: 26 start-page: 432 issue: 4 year: 2011 end-page: 439 ident: CR31 article-title: Serum TSH level in healthy Koreans and the association of TSH with serum lipid concentration and metabolic syndrome publication-title: Korean J. Intern. Med. doi: 10.3904/kjim.2011.26.4.432 contributor: fullname: Park – volume: 62 start-page: 301 issue: 3 year: 2009 end-page: 305 ident: CR30 article-title: Thyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women publication-title: Maturitas doi: 10.1016/j.maturitas.2009.01.007 contributor: fullname: Kim – volume: 13 start-page: e1007081 issue: 11 year: 2017 ident: CR21 article-title: Orienting the causal relationship between imprecisely measured traits using GWAS summary data publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1007081 contributor: fullname: Davey Smith – volume: 24 start-page: 278 issue: 3 year: 2003 end-page: 301 ident: CR2 article-title: Insulin resistance and chronic cardiovascular inflammatory syndrome publication-title: Endocr. Rev. doi: 10.1210/er.2002-0010 contributor: fullname: Ricart – volume: 60 start-page: 941 issue: 8 year: 2013 end-page: 950 ident: CR35 article-title: Decreased fasting blood glucose is associated with impaired hepatic glucose production in thyroid-stimulating hormone receptor knockout mice publication-title: Endocr. J. doi: 10.1507/endocrj.EJ12-0462 contributor: fullname: Gao – volume: 13 start-page: 146 year: 2014 ident: CR8 article-title: Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance publication-title: Cardiovasc. Diabetol. doi: 10.1186/s12933-014-0146-3 contributor: fullname: Yu – volume: 316 start-page: E510 issue: 3 year: 2019 end-page: e8 ident: CR54 article-title: ER stress contributes to high-fat diet-induced decrease of thyroglobulin and hypothyroidism publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00194.2018 contributor: fullname: Fang – volume: 25 start-page: 1095 issue: 12 year: 2015 end-page: 1103 ident: CR57 article-title: Lower-normal TSH is associated with better metabolic risk factors: a cross-sectional study on Spanish men publication-title: Nutr. Metab. Cardiovasc. Dis. doi: 10.1016/j.numecd.2015.09.007 contributor: fullname: Andres – volume: 72 start-page: 696 issue: 5 year: 2010 end-page: 701 ident: CR33 article-title: A high normal TSH is associated with the metabolic syndrome publication-title: Clin. Endocrinol. doi: 10.1111/j.1365-2265.2009.03698.x contributor: fullname: Spranger – volume: 56 start-page: 963 issue: 5 year: 2015 end-page: 971 ident: CR37 article-title: Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver publication-title: J. Lipid Res. doi: 10.1194/jlr.M047654 contributor: fullname: Gao – volume: 20 start-page: 134 issue: 1 year: 2021 ident: CR29 article-title: The usefulness of obesity and lipid-related indices to predict the presence of Non-alcoholic fatty liver disease publication-title: Lipids Health Dis. doi: 10.1186/s12944-021-01561-2 contributor: fullname: Zou – volume: 47 start-page: 382 issue: 5 year: 2016 end-page: 387 ident: CR5 article-title: Fasting triglycerides and glucose index as a diagnostic test for insulin resistance in young adults publication-title: Arch. Med. Res. doi: 10.1016/j.arcmed.2016.08.012 contributor: fullname: Murguía-Romero – volume: 106 start-page: e4251 issue: 10 year: 2021 end-page: e4259 ident: CR19 article-title: Causal association between serum thyrotropin and obesity: a bidirectional, mendelian randomization study publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/clinem/dgab183 contributor: fullname: Wang – volume: 6 start-page: 299 issue: 4 year: 2008 end-page: 304 ident: CR4 article-title: The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects publication-title: Metab. Syndr. Relat. Disord. doi: 10.1089/met.2008.0034 contributor: fullname: Guerrero-Romero – volume: 52 start-page: 1579 issue: 6 year: 2005 end-page: 1609 ident: CR1 article-title: Type 2 diabetes mellitus in youth: the complete picture to date publication-title: Pediatr. Clin. North Am. doi: 10.1016/j.pcl.2005.07.009 contributor: fullname: Arslanian – volume: 32 start-page: 1 issue: 1 year: 2003 end-page: 22 ident: CR14 article-title: Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyg070 contributor: fullname: Ebrahim – volume: 20 start-page: 206 issue: 1 year: 2021 ident: CR28 article-title: Gender difference in the association between TyG index and subclinical atherosclerosis: results from the I-Lan Longitudinal Aging Study publication-title: Cardiovasc. Diabetol. doi: 10.1186/s12933-021-01391-7 contributor: fullname: Chen – volume: 16 start-page: e0254630 issue: 7 year: 2021 ident: CR39 article-title: Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015 publication-title: PLoS One doi: 10.1371/journal.pone.0254630 contributor: fullname: Kang – volume: 89 start-page: 649 issue: 5 year: 2018 end-page: 655 ident: CR44 article-title: Association between thyroid hormone levels, body composition and insulin resistance in euthyroid subjects with normal thyroid ultrasound: The Kangbuk Samsung Health Study publication-title: Clin Endocrinol. doi: 10.1111/cen.13823 contributor: fullname: Lee – volume: 14 issue: 1 year: 2016 ident: CR34 article-title: Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study publication-title: BMC Med. doi: 10.1186/s12916-016-0693-4 contributor: fullname: Peeters – volume: 33 start-page: 640 issue: 9 year: 2010 end-page: 643 ident: CR13 article-title: Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects publication-title: J. Endocrinol. Investig. doi: 10.1007/BF03346663 contributor: fullname: Morricone – volume: 10 start-page: e0125922 issue: 5 year: 2015 ident: CR45 article-title: Novel clinical evidence of an association between homocysteine and insulin resistance in patients with hypothyroidism or subclinical hypothyroidism publication-title: PLoS One doi: 10.1371/journal.pone.0125922 contributor: fullname: Fan – volume: 14 start-page: 1484 issue: 12 year: 2009 end-page: 1495 ident: CR49 article-title: Diabetes and apoptosis: lipotoxicity publication-title: Apoptosis doi: 10.1007/s10495-009-0352-8 contributor: fullname: Scherer – volume: 329 start-page: 1988 issue: 27 year: 1993 end-page: 1992 ident: CR10 article-title: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199312303292703 contributor: fullname: Ravussin – volume: 7 year: 2020 ident: CR18 article-title: Causal effect of the triglyceride-glucose index and the joint exposure of higher glucose and triglyceride with extensive cardio-cerebrovascular metabolic outcomes in the UK biobank: a Mendelian randomization study publication-title: Front Cardiovasc Med doi: 10.3389/fcvm.2020.583473 contributor: fullname: Yuan – volume: 19 start-page: 3284 issue: 10 year: 2018 ident: CR59 article-title: Novel transcriptional mechanisms for regulating metabolism by thyroid hormone publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19103284 contributor: fullname: Yen – volume: 8 start-page: 449 year: 2023 ident: CR22 article-title: MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data publication-title: Wellcome Open Res. doi: 10.12688/wellcomeopenres.19995.2 contributor: fullname: Woolf – volume: 2018 year: 2018 ident: CR52 article-title: Palmitic acid downregulates thyroglobulin (Tg), sodium iodide symporter (NIS), and thyroperoxidase (TPO) in human primary thyrocytes: a potential mechanism by which lipotoxicity affects thyroid? publication-title: Int. J. Endocr. doi: 10.1155/2018/4215848 contributor: fullname: Yu – volume: 13 start-page: 362 issue: 8 year: 2015 end-page: 369 ident: CR42 article-title: Thyrotropin levels, insulin resistance, and metabolic syndrome: a cross-sectional analysis in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) publication-title: Metab. Syndr. Relat. Disord. doi: 10.1089/met.2015.0045 contributor: fullname: Lotufo – volume: 95 start-page: 3347 issue: 7 year: 2010 end-page: 3351 ident: CR25 article-title: The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2010-0288 contributor: fullname: Hernández-González – volume: 75 start-page: 404 issue: 3 year: 2011 end-page: 406 ident: CR56 article-title: Thyrotropin-lowering effect of metformin in a patient with resistance to thyroid hormone publication-title: Clin. Endocrinol. doi: 10.1111/j.1365-2265.2011.04058.x contributor: fullname: Okopien – volume: 2020 year: 2020 ident: CR51 article-title: Quantitative analysis of the proteome and the succinylome in the thyroid tissue of high-fat diet-induced hypothyroxinemia in rats publication-title: Int. J. Endocr. doi: 10.1155/2020/3240198 contributor: fullname: Zhao – volume: 160 start-page: 785 issue: 5 year: 2009 end-page: 790 ident: CR46 article-title: Studies of insulin resistance in patients with clinical and subclinical hypothyroidism publication-title: Eur. J. Endocrinol. doi: 10.1530/EJE-08-0797 contributor: fullname: Alevizaki – volume: 28 start-page: 780 issue: 6 year: 2018 end-page: 798 ident: CR53 article-title: NFE2-related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland publication-title: Thyroid doi: 10.1089/thy.2018.0018 contributor: fullname: Renaud – volume: 50 start-page: 693 issue: 5 year: 2018 end-page: 698 ident: CR23 article-title: Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases publication-title: Nat. Genet. doi: 10.1038/s41588-018-0099-7 contributor: fullname: Do – volume: 11 start-page: e0163465 issue: 9 year: 2016 ident: CR26 article-title: Predictive value of triglyceride glucose index for the risk of incident diabetes: a 4-year retrospective longitudinal study publication-title: PLoS One doi: 10.1371/journal.pone.0163465 contributor: fullname: Oh – volume: 41 start-page: 480 issue: 6 year: 2015 end-page: 488 ident: CR58 article-title: Association between thyroid hormones, thyroid antibodies and insulin resistance in euthyroid individuals: a population-based cohort publication-title: Diabetes Metab. doi: 10.1016/j.diabet.2015.04.004 contributor: fullname: Azizi – volume: 598 start-page: 2977 issue: 14 year: 2020 end-page: 2993 ident: CR50 article-title: Cardiomyopathy in obesity, insulin resistance and diabetes publication-title: J. Physiol. doi: 10.1113/JP276747 contributor: fullname: Sadoshima – volume: 47 start-page: 382 issue: 5 year: 2016 ident: 3858_CR5 publication-title: Arch. Med. Res. doi: 10.1016/j.arcmed.2016.08.012 contributor: fullname: F Guerrero-Romero – volume: 19 start-page: 3284 issue: 10 year: 2018 ident: 3858_CR59 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19103284 contributor: fullname: BK Singh – volume: 318 start-page: 371 issue: 4 year: 2017 ident: 3858_CR15 publication-title: JAMA doi: 10.1001/jama.2017.8981 contributor: fullname: SC Larsson – volume: 14 start-page: 1484 issue: 12 year: 2009 ident: 3858_CR49 publication-title: Apoptosis doi: 10.1007/s10495-009-0352-8 contributor: fullname: CM Kusminski – volume: 13 start-page: 362 issue: 8 year: 2015 ident: 3858_CR42 publication-title: Metab. Syndr. Relat. Disord. doi: 10.1089/met.2015.0045 contributor: fullname: IM Benseñor – volume: 25 start-page: 1095 issue: 12 year: 2015 ident: 3858_CR57 publication-title: Nutr. Metab. Cardiovasc. Dis. doi: 10.1016/j.numecd.2015.09.007 contributor: fullname: M Laclaustra – volume: 28 start-page: 166 issue: 1 year: 2019 ident: 3858_CR20 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddy327 contributor: fullname: SL Pulit – volume: 13 start-page: 146 year: 2014 ident: 3858_CR8 publication-title: Cardiovasc. Diabetol. doi: 10.1186/s12933-014-0146-3 contributor: fullname: T Du – volume: 2018 year: 2018 ident: 3858_CR52 publication-title: Int. J. Endocr. doi: 10.1155/2018/4215848 contributor: fullname: M Zhao – volume: 20 start-page: 206 issue: 1 year: 2021 ident: 3858_CR28 publication-title: Cardiovasc. Diabetol. doi: 10.1186/s12933-021-01391-7 contributor: fullname: YW Lu – volume: 11 issue: 1 year: 2021 ident: 3858_CR40 publication-title: Sci. Rep. doi: 10.1038/s41598-021-01101-z contributor: fullname: YM Choi – volume: 75 start-page: 404 issue: 3 year: 2011 ident: 3858_CR56 publication-title: Clin. Endocrinol. doi: 10.1111/j.1365-2265.2011.04058.x contributor: fullname: R Krysiak – volume: 28 start-page: 780 issue: 6 year: 2018 ident: 3858_CR53 publication-title: Thyroid doi: 10.1089/thy.2018.0018 contributor: fullname: PG Ziros – volume: 33 start-page: 640 issue: 9 year: 2010 ident: 3858_CR13 publication-title: J. Endocrinol. Investig. doi: 10.1007/BF03346663 contributor: fullname: B Ambrosi – volume: 960 start-page: 277 year: 2017 ident: 3858_CR48 publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-3-319-48382-5_12 contributor: fullname: D Yazıcı – volume: 42 start-page: 1569 issue: 8 year: 2019 ident: 3858_CR11 publication-title: Diabetes Care doi: 10.2337/dc18-1920 contributor: fullname: K Park – volume: 6 start-page: 299 issue: 4 year: 2008 ident: 3858_CR4 publication-title: Metab. Syndr. Relat. Disord. doi: 10.1089/met.2008.0034 contributor: fullname: LE Simental-Mendía – volume: 11 start-page: e10063 issue: 2 year: 2022 ident: 3858_CR43 publication-title: Eur. Thyroid J. doi: 10.1530/ETJ-21-0063 contributor: fullname: D Spira – volume: 10 start-page: 93 year: 2011 ident: 3858_CR7 publication-title: Cardiovasc. Diabetol. doi: 10.1186/1475-2840-10-93 contributor: fullname: JK Chiang – volume: 14 start-page: 2147 issue: 6 year: 2020 ident: 3858_CR41 publication-title: Diabetes Metab. Syndr. doi: 10.1016/j.dsx.2020.11.008 contributor: fullname: E Kocatürk – volume: 30 start-page: 543 issue: 7 year: 2015 ident: 3858_CR17 publication-title: Eur. J. Epidemiol. doi: 10.1007/s10654-015-0011-z contributor: fullname: S Burgess – volume: 329 start-page: 1988 issue: 27 year: 1993 ident: 3858_CR10 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199312303292703 contributor: fullname: S Lillioja – volume: 2019 year: 2019 ident: 3858_CR27 publication-title: Can. J. Gastroenterol. Hepatol. doi: 10.1155/2019/5121574 contributor: fullname: A Kitae – volume: 90 start-page: 5698 issue: 10 year: 2005 ident: 3858_CR3 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2005-0799 contributor: fullname: CH Saely – volume: 14 issue: 1 year: 2016 ident: 3858_CR34 publication-title: BMC Med. doi: 10.1186/s12916-016-0693-4 contributor: fullname: L Chaker – volume: 52 start-page: 1579 issue: 6 year: 2005 ident: 3858_CR1 publication-title: Pediatr. Clin. North Am. doi: 10.1016/j.pcl.2005.07.009 contributor: fullname: N Gungor – volume: 30 start-page: 2072 issue: 11 year: 2020 ident: 3858_CR12 publication-title: Nutr. Metab. Cardiovasc. Dis. doi: 10.1016/j.numecd.2020.06.019 contributor: fullname: Y Liu – volume: 24 start-page: 278 issue: 3 year: 2003 ident: 3858_CR2 publication-title: Endocr. Rev. doi: 10.1210/er.2002-0010 contributor: fullname: JM Fernández-Real – volume: 12 year: 2021 ident: 3858_CR9 publication-title: Front. Endocrinol. doi: 10.3389/fendo.2021.661160 contributor: fullname: J He – volume: 50 start-page: 693 issue: 5 year: 2018 ident: 3858_CR23 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0099-7 contributor: fullname: M Verbanck – volume: 160 start-page: 785 issue: 5 year: 2009 ident: 3858_CR46 publication-title: Eur. J. Endocrinol. doi: 10.1530/EJE-08-0797 contributor: fullname: E Maratou – volume: 25 start-page: 141 issue: 2 year: 2010 ident: 3858_CR47 publication-title: Indian J. Clin. Biochem. doi: 10.1007/s12291-010-0026-x contributor: fullname: BM Singh – volume: 41 start-page: 480 issue: 6 year: 2015 ident: 3858_CR58 publication-title: Diabetes Metab. doi: 10.1016/j.diabet.2015.04.004 contributor: fullname: A Amouzegar – volume: 32 start-page: 1 issue: 1 year: 2003 ident: 3858_CR14 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyg070 contributor: fullname: GD Smith – volume: 52 start-page: 1401 issue: 4 year: 2010 ident: 3858_CR36 publication-title: Hepatology doi: 10.1002/hep.23800 contributor: fullname: L Tian – volume: 61 start-page: 1358 issue: 6 year: 2014 ident: 3858_CR38 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2014.06.037 contributor: fullname: F Yan – volume: 13 start-page: e1007081 issue: 11 year: 2017 ident: 3858_CR21 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1007081 contributor: fullname: G Hemani – volume: 8 start-page: 449 year: 2023 ident: 3858_CR22 publication-title: Wellcome Open Res. doi: 10.12688/wellcomeopenres.19995.2 contributor: fullname: A Patel – volume: 106 start-page: e4251 issue: 10 year: 2021 ident: 3858_CR19 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/clinem/dgab183 contributor: fullname: X Wang – volume: 28 start-page: 180 issue: 2 year: 2013 ident: 3858_CR32 publication-title: Korean J. Intern. Med. doi: 10.3904/kjim.2013.28.2.180 contributor: fullname: JY Oh – volume: 10 start-page: e0125922 issue: 5 year: 2015 ident: 3858_CR45 publication-title: PLoS One doi: 10.1371/journal.pone.0125922 contributor: fullname: N Yang – volume: 316 start-page: E510 issue: 3 year: 2019 ident: 3858_CR54 publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00194.2018 contributor: fullname: X Zhang – volume: 20 start-page: 134 issue: 1 year: 2021 ident: 3858_CR29 publication-title: Lipids Health Dis. doi: 10.1186/s12944-021-01561-2 contributor: fullname: G Sheng – volume: 2020 year: 2020 ident: 3858_CR51 publication-title: Int. J. Endocr. doi: 10.1155/2020/3240198 contributor: fullname: B Hu – volume: 89 start-page: 649 issue: 5 year: 2018 ident: 3858_CR44 publication-title: Clin Endocrinol. doi: 10.1111/cen.13823 contributor: fullname: H Kwon – volume: 72 start-page: 696 issue: 5 year: 2010 ident: 3858_CR33 publication-title: Clin. Endocrinol. doi: 10.1111/j.1365-2265.2009.03698.x contributor: fullname: S Ruhla – volume: 11 start-page: e0163465 issue: 9 year: 2016 ident: 3858_CR26 publication-title: PLoS One doi: 10.1371/journal.pone.0163465 contributor: fullname: DY Lee – volume: 32 start-page: 266 issue: 3 year: 2018 ident: 3858_CR6 publication-title: J. Diabetes Complic. doi: 10.1016/j.jdiacomp.2017.10.007 contributor: fullname: M Mazidi – volume: 56 start-page: 963 issue: 5 year: 2015 ident: 3858_CR37 publication-title: J. Lipid Res. doi: 10.1194/jlr.M047654 contributor: fullname: X Zhang – volume: 16 start-page: e0254630 issue: 7 year: 2021 ident: 3858_CR39 publication-title: PLoS One doi: 10.1371/journal.pone.0254630 contributor: fullname: W Choi – volume: 26 start-page: 432 issue: 4 year: 2011 ident: 3858_CR31 publication-title: Korean J. Intern. Med. doi: 10.3904/kjim.2011.26.4.432 contributor: fullname: YK Lee – volume: 95 start-page: 3347 issue: 7 year: 2010 ident: 3858_CR25 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2010-0288 contributor: fullname: F Guerrero-Romero – volume: 30 start-page: 568 issue: 4 year: 2020 ident: 3858_CR24 publication-title: Thyroid doi: 10.1089/thy.2019.0067 contributor: fullname: Y Li – volume: 60 start-page: 941 issue: 8 year: 2013 ident: 3858_CR35 publication-title: Endocr. J. doi: 10.1507/endocrj.EJ12-0462 contributor: fullname: T Wang – volume: 42 start-page: 303 issue: 2 year: 2019 ident: 3858_CR55 publication-title: Diabetes Care doi: 10.2337/dc18-1410 contributor: fullname: M Laclaustra – volume: 369 start-page: m997 year: 2020 ident: 3858_CR16 publication-title: BMJ doi: 10.1136/bmj.m997 contributor: fullname: Y Li – volume: 7 year: 2020 ident: 3858_CR18 publication-title: Front Cardiovasc Med doi: 10.3389/fcvm.2020.583473 contributor: fullname: S Si – volume: 598 start-page: 2977 issue: 14 year: 2020 ident: 3858_CR50 publication-title: J. Physiol. doi: 10.1113/JP276747 contributor: fullname: M Nakamura – volume: 62 start-page: 301 issue: 3 year: 2009 ident: 3858_CR30 publication-title: Maturitas doi: 10.1016/j.maturitas.2009.01.007 contributor: fullname: HT Park |
SSID | ssj0022267 |
Score | 2.4481034 |
Snippet | Background
Metabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the... Metabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the... BackgroundMetabolic diseases are associated with thyroid disorders. Insulin resistance is the common pathological basis of metabolic diseases. We explored the... |
SourceID | proquest crossref pubmed springer |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 173 |
SubjectTerms | Adult Aged Blood Glucose - analysis Cross-Sectional Studies Diabetes Diabetes mellitus Endocrinology Epidemiology Female Genome-wide association studies Humanities and Social Sciences Humans Hypothyroidism Hypothyroidism - blood Hypothyroidism - epidemiology Hypothyroidism - genetics Insulin Resistance Internal Medicine Iodine Male Medicine Medicine & Public Health Mendelian Randomization Analysis Menopause Metabolic disorders Middle Aged multidisciplinary Original Article Prevalence Science Thyroid diseases Thyroid Diseases - blood Thyroid Diseases - epidemiology Thyroid Diseases - genetics Thyroid gland Thyroid-stimulating hormone Thyrotropin - blood Triglycerides - blood Womens health |
Title | Association between the triglyceride-glucose index and thyroid disorders: a cross-sectional survey and Mendelian randomization analysis |
URI | https://link.springer.com/article/10.1007/s12020-024-03858-5 https://www.ncbi.nlm.nih.gov/pubmed/38782862 https://www.proquest.com/docview/3112100133 https://www.proquest.com/docview/3060375129/abstract/ |
Volume | 86 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT8JAEJ4IJMaLD_CBIlkT40WXtN0-wBsxKtHgSRI8Nd3uNjFKMVBM8A_4t53dbkGDHrw12Wl3O_v6dmfmG4BTlkRu0LYYjaTdpq4jcR2UIqFBEjh-Ykue--b0H_zewL0besNlHLd2di8sknqhXsa6Oeqkg1sK1cYs6pWg4inCrzJUurdP99eLcxYiisDEx_z-5s89aAVYrhhF9V5zswWPRcRO7mLy0pplvBV_rBI4_uc3tmHTYE_SzQfLDqzJtAq1born7tGcnBHtDaqv2auw3jdG9xp8futCYvy6COJGkuHJ_nUe4xgWsvB9J5p-kUSpQJH5ZPwsiDAEn9NLEhGtETrVDmCqMdPZ5F3OtXxf3carWxeC-6cYj0yEKJblvCm7MLi5frzqUZO_gcYICjPqCyvo-DjppW_HseVzZnM74K5gvidchuij4_J2nESMeSxCIMoSrkJhmZUwgY9sD8rpOJUHQNzE5SyWllCpgjyVcEvGHo86wpZBx5FeHc6LHg3fcpqOcEnIrFQeospDrfIQpRtFp4dmyk5DZisuNayd1eFkUYyTTVlQolSOZyhj-SpnMGKkOuzng2VRHWsHKiTfqcNF0fPLj__dlsP_iR_BhqMGj3YnbEA5m8zkMcKijDfNNGhCaeB0vwByhgY8 |
link.rule.ids | 315,786,790,27955,27956,41114,41556,42183,42625,52144,52267 |
linkProvider | Springer Nature |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Nb9MwFH8arQS7wGjH6CjDSIgL85TETtJyq1BLRz9OrVROURw7EtqaoiZFKv8A__aeHacFCofeIvklduxnv9_z-wJ4x9KYhx2H0Vi5Hco9heegkikN09ALUleJ0jdnMg2Gc_5l4S9sUFheebtXJklzUu-D3Tyt6qBMocaaRf1HUOdawteg3vv8ddTfKVoIKUIbIPPvN_8UQgfI8sAqaoTN4BnMq2GWPiZ3N5tC3CQ__8rgeOx_nMFTiz5Jr2SX53CisgY0exlq3ssteU-MP6i5aG_A44k1uzfh12-LSKxnF0HkSArU7e-3CXKxVJX3OzEJGEmcSSTZrlffJJE2xWf-kcTETAnNjQuYHky-Wf9QW0M_0ffx-t6FoASVq6WNEcW2MnPKOcwH_dmnIbUVHGiCsLCggXTCboDbXgVukjiBYK5wQ8ElC3zJGeKPLhedJI0Z81mMUJSlQgfDMidlEh_ZC6hlq0y9BMJTLliiHKmLBfm65JZKfBF3pavCrqf8FnyoljT6XibqiPYpmfWURzjlkZnyCKnb1apHdtPmEXN1NjXsnbXg7a4Zt5u2ocSZWm2Qxgl01WBESS24KLll1x3rhDoo32vBdbXy-4__fyyXx5G_gSfD2WQcjW-no1dw6mlGMs6FbagV6416jSCpEFd2TzwAsScJJw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dT9swED9BkRAvbHyuW7cZCfECLknsJO3eqo2ODYr2MCR4iuzYltAgrdp0UvcP7N_e2XFaxsfDtLdIvsSOfef7ne_DAPvMCJ52AkaFDjuURxr3Qa0MTU0aJSbUsorNGVwkp5f861V8dS-L30W71y7JKqfBVmkqyuORMseLxLfImj2oX6jzbNF4GVY4ii1vwErv8_XZydzoQniR-mSZp9_8WyE9QpmPPKRO8fRfgKiHXMWb_GhPS9nOfz2o5vg___QS1j0qJb2KjTZgSRebsNUr0CK_m5ED4uJE3QH8JqwOvDt-C37fW1ziI74IIkpSos1_O8uRu5Wuo-KJK8xIRKGQZDYe3iiifOnPyQciiJseOnGhYXYwk-n4p545-oE9p7fnMQQ1qxre-dxRbKsqqmzDZf_k-8dT6m92oDnCxZImKki7CW4HOgnzPEgkC2WYSq5YEivOEJd0uezkRjAWM4EQlRlpk2RZYJjCR7YDjWJY6FdAuOGS5TpQ9hKh2F7FpfNYiq4KddqNdNyEw3p5s1FVwCNblGq2U57hlGduyjOkbtUckHlhnmQstFXWsHfWhL15M4qh9a2IQg-nSBMk9jZhRE9N2K04Z94d66Q2WT9qwlHNBYuPPz-W1_9G_h5Wv33qZ-dfLs7ewFpk-cjFHLagUY6n-i1ip1K-8-LxB-zpEgI |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+between+the+triglyceride-glucose+index+and+thyroid+disorders%3A+a+cross-sectional+survey+and+Mendelian+randomization+analysis&rft.jtitle=Endocrine&rft.au=Zhang%2C+Chenyu&rft.au=Wang%2C+Haoyu&rft.au=Li%2C+Yongze&rft.au=Wang%2C+Xichang&rft.date=2024-10-01&rft.issn=1559-0100&rft.eissn=1559-0100&rft.volume=86&rft.issue=1&rft.spage=173&rft.epage=185&rft_id=info:doi/10.1007%2Fs12020-024-03858-5&rft.externalDBID=n%2Fa&rft.externalDocID=10_1007_s12020_024_03858_5 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1559-0100&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1559-0100&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1559-0100&client=summon |