Oxidative stress elicits platelet/leukocyte inflammatory interactions via HMGB1: a candidate for microvessel injury in sytemic sclerosis

• Published in: Antioxidants & redox signaling Vol. 20; no. 7; p. 1060
• Main Authors: Maugeri, Norma, Rovere-Querini, Patrizia, Baldini, Mattia, Baldissera, Elena, Sabbadini, Maria Grazia, Bianchi, Marco E, Manfredi, Angelo A
• Format: Journal Article
• Language: English
• Published: United States 01.03.2014
• Subjects: Adult; Aged; Aged, 80 and over; Blood Platelets - metabolism; Blood Platelets - physiology; CD18 Antigens - metabolism; Female; HMGB1 Protein - metabolism; Humans; Hypertension, Pulmonary - metabolism; Hypertension, Pulmonary - physiopathology; Inflammation - metabolism; Inflammation - physiopathology; Leukocytes - metabolism; Leukocytes - physiology; Male; Microvessels - metabolism; Microvessels - physiopathology; Middle Aged; Neutrophils - metabolism; Neutrophils - physiology; Oxidation-Reduction; Oxidative Stress - physiology; P-Selectin - metabolism; Platelet Activation - physiology; Reactive Oxygen Species - metabolism; Scleroderma, Systemic - metabolism; Scleroderma, Systemic - physiopathology; Transcriptional Activation - physiology

An abnormal generation of reactive oxygen species (ROS) is thought to contribute to systemic sclerosis (SSc), fostering autoimmunity, fibrosis, and vascular inflammation. The function of the prototypic damage-associated molecular pattern, high mobility group box 1 (HMGB1), depends on its redox statu...