Inhibition of hepatic stellate cell activation by nutraceuticals: an emphasis on mechanisms of action

• Published in: Journal of food science and technology Vol. 61; no. 11; pp. 2046 - 2056
• Main Authors: Sekar, Vasudevan, VP, Venkateish, Vijay, Vani, BR, Annapoorna, Vijayan, Nivya, Perumal, Madan Kumar
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.11.2024; Springer Nature B.V
• Subjects: Cell activation; Cell death; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Cirrhosis; Clinical trials; Dietary supplements; Drug development; Fatty liver; FDA approval; Fibrosis; Food Science; Functional foods & nutraceuticals; Hepatocellular carcinoma; Hepatocytes; Herbal medicine; Liver; Liver cirrhosis; Liver diseases; Monoclonal antibodies; Morbidity; Nutrition; Review Article; Stellate cells; Anti-fibrotic effect; Hepatic stellate cells; Activation; Liver fibrosis; Dysregulated pathways; Nutraceuticals

Liver diseases emerge as a serious threat to humans worldwide due to increasing morbidity and mortality. Liver disease related deaths accounts for one third of all disease related death globally. A simple fatty liver if unattended advances further to liver fibrosis, cirrhosis and hepatocellular carc...