Mutation of TRPML1 Channel and Pathogenesis of Neurodegeneration in Haimeria

• Published in: Molecular neurobiology Vol. 61; no. 8; pp. 4992 - 5001
• Main Authors: Gao, Junqing, Li, Huanhuan, Lv, Hua, Cheng, Xiansong
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2024; Springer Nature B.V
• Subjects: Alzheimer's disease; Attention; Biomedical and Life Sciences; Biomedicine; Cell Biology; Medical innovations; Molecular modelling; Neurobiology; Neurodegeneration; Neurodegenerative diseases; Neurology; Neurosciences; Pathogenesis; Reviews; Therapeutic applications; Transient receptor potential proteins; Well being; Alzheimer’s disease; Neurodegeneration; Therapeutic potential; TRPML1 channels
• ISSN: 0893-7648; 1559-1182; 1559-1182
• DOI: 10.1007/s12035-023-03874-y

Neurodegenerative diseases, a group of debilitating disorders, have garnered increasing attention due to their escalating prevalence, particularly among aging populations. Alzheimer’s disease (AD) reigns as a prominent exemplar within this category, distinguished by its relentless progression of cognitive impairment and the accumulation of aberrant protein aggregates within the intricate landscape of the brain. While the intricate pathogenesis of neurodegenerative diseases has been the subject of extensive investigation, recent scientific inquiry has unveiled a novel player in this complex scenario—transient receptor potential mucolipin 1 (TRPML1) channels. This comprehensive review embarks on an exploration of the intricate interplay between TRPML1 channels and neurodegenerative diseases, with an explicit spotlight on Alzheimer’s disease. It immerses itself in the intricate molecular mechanisms governing TRPML1 channel functionality and elucidates their profound implications for the well-being of neurons. Furthermore, the review ventures into the realm of therapeutic potential, pondering the possibilities and challenges associated with targeting TRPML1 channels as a promising avenue for the amelioration of neurodegenerative disorders. As we traverse this multifaceted terrain of neurodegeneration and the enigmatic role of TRPML1 channels, we embark on a journey that not only broadens our understanding of the intricate machinery governing neuronal health but also holds promise for the development of innovative therapeutic interventions in the relentless battle against neurodegenerative diseases.