Chronic Iodine Intake Excess Damages the Structure of Articular Cartilage and Epiphyseal Growth Plate

• Published in: Biological trace element research Vol. 202; no. 9; pp. 4078 - 4086
• Main Authors: Zhang, Ying, Zhao, Xin, Shan, Le, Liu, Miao, Zhang, Zixuan, Wang, Zeji, Zhang, Xinbao, Meng, Haohao, Song, Yan, Zhang, Wanqi, Sang, Zhongna
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2024; Springer Nature B.V
• Subjects: Animals; Arsenic; Biochemistry; Biomedical and Life Sciences; Biotechnology; Cartilage; Cartilage (articular); Cartilage diseases; Cartilage, Articular - drug effects; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Cerium; Chemiluminescence; Chondrocytes; Collagen; Collagen (type II); Collagen (type X); Collagenase 3; Epiphyseal growth plate; Fibroblast growth factor receptor 1; Gene expression; Growth factors; Growth plate; Growth Plate - drug effects; Growth Plate - metabolism; Growth Plate - pathology; Hypothyroidism; Iodine; Iodine - urine; Life Sciences; Male; Matrix metalloproteinase; Matrix Metalloproteinase 13 - genetics; Matrix Metalloproteinase 13 - metabolism; Matrix metalloproteinases; Metalloproteinase; Nucleotide sequence; Nutrition; Oncology; Osteoarthritis; Overdose; PCR; Rats; Rats, Wistar; Spectrophotometry; Thickness; Thyroid; Growth plate; Iodine excess; Rat; Articular cartilage; Thyroid function

This study aimed to explore the influence of excess iodine on the articular cartilage and epiphyseal growth plate in rats. Wistar rats ( n  = 200) were randomly divided into five groups with 40 rats in each: normal iodine (NI), 5-fold high iodine group (5HI), 10-fold high iodine group (10HI), 50-fol...