Contribution of haptoglobin phenotypic variation to the presence of hyperhomocysteinemia in type 2 diabetics with and without angiopathy

• Published in: European journal of clinical nutrition Vol. 79; no. 3; pp. 266 - 272
• Main Authors: Ferreira, Isabel, Bicho, Manuel, Valente, Ana
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2025; Nature Publishing Group
• Subjects: 692/499; 692/53; Adult; Aged; Cardiovascular diseases; Case-Control Studies; Clinical Nutrition; Cysteine - blood; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetic Angiopathies - blood; Diabetic Angiopathies - complications; Diabetic Angiopathies - genetics; Electrochemiluminescence; Electrophoresis; Epidemiology; Female; Gene polymorphism; Genotype; Genotype & phenotype; Haptoglobin; Haptoglobins - genetics; Haptoglobins - metabolism; Health risks; Heterosis; High performance liquid chromatography; Homocysteine; Homocysteine - blood; Humans; Hyperhomocysteinemia; Hyperhomocysteinemia - blood; Hyperhomocysteinemia - complications; Hyperhomocysteinemia - genetics; Internal Medicine; Liquid chromatography; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Peroxidase; Phenotype; Phenotypes; Phenotypic variations; Plasma levels; Polyacrylamide; Polymorphism; Polymorphism, Genetic; Public Health; Risk Factors; Sodium dodecyl sulfate; Sodium lauryl sulfate; Vitamin B 12 - blood; Vitamin B12; Vitamin B6; Vitamins

Background/Aim The genetic polymorphism of haptoglobin (Hp) has been associated with several cardiovascular risk factors, but a possible relationship between Hp phenotypic variation and increased levels of homocysteine (Hcy) and cysteine (Cy) is still unknown. The objective of this study is to evalu...