XB130 deficiency enhances carcinogen-induced skin tumorigenesis

• Published in: Carcinogenesis (New York) Vol. 40; no. 11; pp. 1363 - 1375
• Main Authors: Cho, Hae-Ra, Wang, Yingchun, Bai, Xiaohui, Xiang, Yun-Yan, Lu, Christina, Post, Alexander, Al Habeeb, Ayman, Liu, Mingyao
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 25.11.2019
• Subjects: 9,10-Dimethyl-1,2-benzanthracene - toxicity; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Carcinogenesis; Carcinogens - toxicity; Cell Proliferation; Female; Genes, Tumor Suppressor; Inflammation; Male; Mice; Mice, Knockout; Microfilament Proteins - genetics; Microfilament Proteins - metabolism; Skin Neoplasms - etiology; Skin Neoplasms - genetics; Skin Neoplasms - metabolism; Skin Neoplasms - physiopathology; Tetradecanoylphorbol Acetate - toxicity

Abstract XB130 is an adaptor protein that functions as a mediator of multiple tyrosine kinases important for regulating cell proliferation, survival, migration and invasion. Formerly predicted as an oncogene, alterations of its expression are documented in various human cancers. However, the exact r...