Association between BanI genotype and increased phospholipase A2 activity in schizophrenia

• Published in: European archives of psychiatry and clinical neuroscience Vol. 257; no. 6; pp. 340 - 343
• Main Authors: Barbosa, Nadia R., Junqueira, Ricardo M., Vallada, Homero P., Gattaz, Wagner F.
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.09.2007
• Subjects: Adult; Blood Platelets - enzymology; Data Interpretation, Statistical; Deoxyribonucleases, Type II Site-Specific - genetics; Female; Gene Frequency; Genotype; Humans; Introns - genetics; Male; Phospholipases A2 - genetics; Polymorphism, Genetic - genetics; Psychiatric Status Rating Scales; Schizophrenia - enzymology; Schizophrenia - genetics

Phospholipases A2 (PLA2) are a family of key enzymes in the metabolism of membrane phospholipids. Several studies reported on increased blood and brain PLA2 activity in schizophrenia, which suggest a disordered phospholipid metabolism in the disease. In addition, a genetic variant of a cytosolic PLA...