SHR0302 Improves Treg/Th17 Imbalance in Patients with Systemic Lupus Erythematosus

• Published in: Indian journal of clinical biochemistry Vol. 40; no. 2; pp. 274 - 283
• Main Authors: Mohammad, Talar Ahmad Merza, Jaafar, Halmat M., Maroof, Avin Mohammad Arif
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.04.2025; Springer Nature B.V
• Subjects: Autoimmune diseases; Biochemistry; Biomedical and Life Sciences; CD25 antigen; CD4 antigen; Chemistry/Food Science; Cytokines; Flow cytometry; Foxp3 protein; Gene expression; Helper cells; Inflammation; Interferon regulatory factor 4; Interleukin 10; Interleukin 21; Interleukin 6; Janus kinase; Life Sciences; Lupus; Lymphocytes T; Microbiology; Original Research Article; Pathology; Signal transduction; Stat3 protein; Systemic lupus erythematosus; Tumor necrosis factor-α; γ-Interferon; Systemic lupus erythematous; Treg/Th17 imbalance; SHR0302

IL-6-mediated JAK1/STAT3 signaling pathway is involved in the development of Th17 cells, which play an essential role in the pathogenesis of various autoimmune diseases such as systemic lupus erythematosus (SLE). To evaluation of the regulatory and anti-inflammatory effects of the JAK1/STAT3 inhibit...