The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

• Published in: Nature (London) Vol. 537; no. 7618; pp. 50 - 56
• Main Authors: Sevigny, Jeff, Chiao, Ping, Bussière, Thierry, Weinreb, Paul H., Williams, Leslie, Maier, Marcel, Dunstan, Robert, Salloway, Stephen, Chen, Tianle, Ling, Yan, O’Gorman, John, Qian, Fang, Arastu, Mahin, Li, Mingwei, Chollate, Sowmya, Brennan, Melanie S., Quintero-Monzon, Omar, Scannevin, Robert H., Arnold, H. Moore, Engber, Thomas, Rhodes, Kenneth, Ferrero, James, Hang, Yaming, Mikulskis, Alvydas, Grimm, Jan, Hock, Christoph, Nitsch, Roger M., Sandrock, Alfred
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2016
• Subjects: 692/308/153; 692/699/375/132; Aged; Aged, 80 and over; Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer Disease - psychology; Amyloid - drug effects; Amyloid - metabolism; Amyloid beta-Peptides - antagonists & inhibitors; Amyloid beta-Peptides - chemistry; Amyloid beta-Peptides - metabolism; Animals; Antibodies, Monoclonal, Humanized - administration & dosage; Antibodies, Monoclonal, Humanized - adverse effects; Antibodies, Monoclonal, Humanized - pharmacokinetics; Antibodies, Monoclonal, Humanized - therapeutic use; Brain - drug effects; Brain - metabolism; Clinical Trials, Phase III as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humanities and Social Sciences; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Models, Biological; multidisciplinary; Plaque, Amyloid - drug therapy; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Protein Aggregation, Pathological - drug therapy; Science; Solubility

Alzheimer’s disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance or mitigate its neurotoxicity has so far been unsucc...