Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation

• Published in: Journal of molecular cell biology Vol. 8; no. 6; pp. 477 - 491
• Main Authors: He, Fengxia, Zhou, Mengya, Yu, Tianyi, Zhao, Dan, Zhang, Jing, Qiu, Wen, Lu, Yanlai, Liu, Yu, Wang, Lulu, Wang, Yingwei
• Format: Journal Article
• Language: English
• Published: United States 01.12.2016
• Subjects: Acetylation; Activating Transcription Factor 3 - genetics; Activating Transcription Factor 3 - metabolism; Animals; Apoptosis; Cell Cycle Proteins - metabolism; Cell Line; Complement Membrane Attack Complex - metabolism; E1A-Associated p300 Protein - metabolism; Early Growth Response Protein 1 - metabolism; Gene Silencing; Lysine - metabolism; Male; Mesangial Cells - metabolism; Mesangial Cells - pathology; Nephritis - complications; Nephritis - metabolism; Nuclear Proteins - metabolism; Proteinuria - complications; Proteinuria - metabolism; Rats, Sprague-Dawley; RNA, Messenger - genetics; RNA, Messenger - metabolism; Thy-1 Antigens; Transcription, Genetic; Up-Regulation; acetylation; transcription factor; apoptosis; glomerular mesangial cells; Thy-1 nephritis; sublytic C5b-9

The apoptosis of glomerular mesangial cells (GMCs) is considered to be an important contributor to the initiation and development of rat Thy-1 nephritis (Thy-1N) and is accompanied by sublytic C5b-9 deposition. However, the mechanism by which sublytic C5b-9 triggers GMC apoptosis has not been elucid...