The Putative Role of Natural Killer Cells in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma
Natural Killer (NK) cells have crucial roles in immune responses against malignant transformation including hepatocellular carcinoma (HCC). The NKG2D receptor has a critical role in the NK recognition of target cells. We assessed NKG2D receptor expression as a diagnostic biomarker for HCC detection...
Saved in:
| Published in | Asian Pacific journal of cancer prevention : APJCP Vol. 22; no. 8; pp. 2559 - 2567 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Thailand
West Asia Organization for Cancer Prevention
01.08.2021
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Natural Killer (NK) cells have crucial roles in immune responses against malignant transformation including hepatocellular carcinoma (HCC). The NKG2D receptor has a critical role in the NK recognition of target cells.
We assessed NKG2D receptor expression as a diagnostic biomarker for HCC detection and progression in Egyptian patients with hepatitis C virus (HCV)-related HCC.
We classified 81 patients into three groups: chronic hepatitis (21), cirrhotic (30) and HCC (30) patients, with 36 individuals enrolled to the control group. We analyzed NK levels in peripheral blood and NKG2D receptor expression in NK cells using flow cytometry.
We observed a significant decrease in NKG2D (CD314) expression on circulating NK cells and frequency of NK cells expressing NKG2D (CD314) in HCC patients. Also, in patients, larger foci lesions significantly correlated with decreased NK cell numbers. Multiple foci numbers and patients with a Child score C significantly correlated with decreased circulating NK cells expressing NKG2D and decreased NKG2D expression.
The percentage of NK cells in peripheral blood and NKG2D receptor expression could function as potential biomarkers for HCC detection and progression. |
|---|---|
| AbstractList | Natural Killer (NK) cells have crucial roles in immune responses against malignant transformation including hepatocellular carcinoma (HCC). The NKG2D receptor has a critical role in the NK recognition of target cells.
We assessed NKG2D receptor expression as a diagnostic biomarker for HCC detection and progression in Egyptian patients with hepatitis C virus (HCV)-related HCC.
We classified 81 patients into three groups: chronic hepatitis (21), cirrhotic (30) and HCC (30) patients, with 36 individuals enrolled to the control group. We analyzed NK levels in peripheral blood and NKG2D receptor expression in NK cells using flow cytometry.
We observed a significant decrease in NKG2D (CD314) expression on circulating NK cells and frequency of NK cells expressing NKG2D (CD314) in HCC patients. Also, in patients, larger foci lesions significantly correlated with decreased NK cell numbers. Multiple foci numbers and patients with a Child score C significantly correlated with decreased circulating NK cells expressing NKG2D and decreased NKG2D expression.
The percentage of NK cells in peripheral blood and NKG2D receptor expression could function as potential biomarkers for HCC detection and progression. |
| Author | Abdel-Samiee, Mohamed Hassouna, Mona M Estaphan, Suzanne Abdelsameea, Eman Abd Elrhman, Heba E Radwan, Enas M Naguib, Mary |
| AuthorAffiliation | 3 Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt 2 Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt 1 Department of Clinical and Chemical Pathology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt 4 Department of Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt 5 Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt |
| AuthorAffiliation_xml | – name: 3 Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt – name: 2 Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt – name: 1 Department of Clinical and Chemical Pathology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt – name: 5 Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt – name: 4 Department of Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt |
| Author_xml | – sequence: 1 givenname: Mona M surname: Hassouna fullname: Hassouna, Mona M organization: Department of Clinical and Chemical Pathology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt – sequence: 2 givenname: Enas M surname: Radwan fullname: Radwan, Enas M organization: Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt – sequence: 3 givenname: Eman orcidid: 0000-0002-3225-7164 surname: Abdelsameea fullname: Abdelsameea, Eman organization: Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt – sequence: 4 givenname: Suzanne surname: Estaphan fullname: Estaphan, Suzanne organization: Department of Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt – sequence: 5 givenname: Heba E surname: Abd Elrhman fullname: Abd Elrhman, Heba E organization: Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt – sequence: 6 givenname: Mohamed orcidid: 0000 0002 8970 0286 surname: Abdel-Samiee fullname: Abdel-Samiee, Mohamed organization: Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt – sequence: 7 givenname: Mary surname: Naguib fullname: Naguib, Mary organization: Department of Clinical and Chemical Pathology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34452571$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkNtKw0AQhhep2IM-grIvkJg9794IJahVi5ZSxbuw2U7syjYpOVR8ewNV0ath-Of7mJkxGpRVCQidkyRmRAh1OV3cp4uYJpTElMY6pkKYIzSiXMlISfo6QCMiCIsUk3qIxk3zniRcaCVO0JBxLqhQZIS2qw3gRdfa1u8BL6sAuCrwo2272gb84EOAGqcQQoN9iRf9GJRtgz98u8Ez2PV96xuc4hdfd020hGBbWB-SyvVYF2zP29r5straU3Rc2NDA2XedoOeb61U6i-ZPt3fpdB45RqWJ1rzIc5BGWlMkRQ7ASG6cA664cqClzDUp1sRRwxJuNQHuhOTMaKeMJtKxCbo6eHddvoW163fuz8l2td_a-jOrrM_-J6XfZG_VPtOSGi5FL7j4K_glfx7HvgBnN3XB |
| CitedBy_id | crossref_primary_10_3390_biomedicines11051391 crossref_primary_10_1177_03936155231169796 crossref_primary_10_1097_MEG_0000000000002337 crossref_primary_10_1016_j_retram_2024_103443 crossref_primary_10_1016_j_amjms_2023_11_022 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 5PM |
| DOI | 10.31557/APJCP.2021.22.8.2559 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2476-762X |
| EndPage | 2567 |
| ExternalDocumentID | 34452571 |
| Genre | Journal Article |
| GeographicLocations | Egypt |
| GeographicLocations_xml | – name: Egypt |
| GroupedDBID | CGR CUY CVF ECM EIF NPM --- 23N 2WC 53G 5GY 5PM 9ZL ADBBV ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV DIK E3Z EBS EJD F5P FRJ GROUPED_DOAJ GX1 HYE JDI OK1 RPM TR2 W2D WOW |
| ID | FETCH-LOGICAL-c3269-d4fbbe696a9f0fbee31b9cce4747ce866b81fd1c29304a81e4c564398c79816c3 |
| IEDL.DBID | RPM |
| ISSN | 1513-7368 |
| IngestDate | Tue Apr 09 21:40:16 EDT 2024 Sat Nov 02 12:28:23 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | natural killer cells Hepatocellular carcinoma NKG2D receptor Hepatitis C Virus |
| Language | English |
| License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3269-d4fbbe696a9f0fbee31b9cce4747ce866b81fd1c29304a81e4c564398c79816c3 |
| ORCID | 0000 0002 8970 0286 0000-0002-3225-7164 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629465/ |
| PMID | 34452571 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_8629465 pubmed_primary_34452571 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-Aug-01 20210801 |
| PublicationDateYYYYMMDD | 2021-08-01 |
| PublicationDate_xml | – month: 08 year: 2021 text: 2021-Aug-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Thailand |
| PublicationPlace_xml | – name: Thailand – name: Iran |
| PublicationTitle | Asian Pacific journal of cancer prevention : APJCP |
| PublicationTitleAlternate | Asian Pac J Cancer Prev |
| PublicationYear | 2021 |
| Publisher | West Asia Organization for Cancer Prevention |
| Publisher_xml | – name: West Asia Organization for Cancer Prevention |
| SSID | ssj0045875 |
| Score | 2.3437598 |
| Snippet | Natural Killer (NK) cells have crucial roles in immune responses against malignant transformation including hepatocellular carcinoma (HCC). The NKG2D receptor... |
| SourceID | pubmedcentral pubmed |
| SourceType | Open Access Repository Index Database |
| StartPage | 2559 |
| SubjectTerms | Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - virology Case-Control Studies Egypt - epidemiology Female Follow-Up Studies Hepacivirus - isolation & purification Hepatitis C - complications Hepatitis C - virology Hepatitis, Chronic - complications Humans Killer Cells, Natural - immunology Killer Cells, Natural - virology Liver Cirrhosis - complications Liver Neoplasms - epidemiology Liver Neoplasms - immunology Liver Neoplasms - pathology Liver Neoplasms - virology Male Middle Aged Prognosis ROC Curve |
| Title | The Putative Role of Natural Killer Cells in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34452571 https://pubmed.ncbi.nlm.nih.gov/PMC8629465 |
| Volume | 22 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pa8IwFA7Og3gZ-z33Q3LYNba1aZocpUzEoZQxhzdp0oQVtBV__P97SVXmdZde0kJ5L-T7XvK9Lwi9UcGZzH1DYqkzQpnMCPDkkPg6FhIYsmG5bU6eTNloRsfzaN5A0bEXxon2lSx65XLVK4sfp61cr5R31Il56SQBFi4oi7wLdAET9Fii18svjbhz1wUkC0kcMl637YSAm7E3SMdJCkVhHyrDfo_3LJ9uo1ZI7eme7aI_odC5QvIP5Ayv0OWBK-JB_U_XqKHLG9SaHE7Db9EKcozT_c55d-PPaqlxZfA0c1Ya-MN1-eFEL5dbXJQ4rR1Ut9huveKRtlLqXbHFCf4uNvstcbI4ndcjld3QtwpVnNjLhspqld2h2fD9KxmRw_UJRAEnEySnRkrNBMuE8Y3UOgykUEpTqCCU5oxJHpg8UAD4Ps14oKmKLD_hKhY8YCq8R82yKvUjwlQEfVu-Mh4ZqiGhhlEJyGaotEe3rIMe6ngt1rVHxuIY0g6KzyJ5esHaWp-PQLadvfUhu0___vIZtW2Ka5neC2ruNnv9CtRhJ7uu5IbnNJ103bT5BYeoxcw |
| link.rule.ids | 230,315,730,783,787,867,888,27936,27937,53804,53806 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1dT4MwFL2ZM1FfjN_Ozz742g1GKe3jQlymjoUYNb4ttLSRZIPFbf_ftjDjXn0uJORe4Jzbe-4pwAPhjIrc0zgSKsOEigwbnhxgT0VcGIasaW6Hk5MJHb2T58_wswXhZhbGifalKLrlbN4tiy-nrVzMZW-jE-ulSWxYOCc07O3ArvlePbIp0usfMAmZ89c1WBbgKKCsHtwJDHJGvUH6HKemLOyb2rDfZV3LqA9gLyC2v2fn6H9xaFsj-Qd0hkdw2LBFNKif6hhaqjyBvaTph5_C3GQZpeuVc-9Gr9VMoUqjSebMNNCLm_NDsZrNlqgoUVp7qC6R3XxFI2XF1KtiiWL0UXyvl9gJ41Rer1R2S99qVFFsjxsqq3l2Bu_Dx7d4hJsDFLA0rIzjnGghFOU049rTQqnAF1xKRUwNIRWjVDBf5740kO-RjPmKyNAyFCYjznwqg3Nol1WpLgER7vdtAUtZqIkyKdWUCINtmgjbvKUduKjjNV3ULhnTTUg7EG1F8vcCa2y9vWLy7Qyum_xe_fvOe9gfvSXj6fhp8nINBzbdtWjvBtqr77W6NURiJe7ca_MDzzvHIQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbsIwELVaKqFequ6lqw-9OgtxHPuI0iIKBUVVqbih2LHVSCFBLP9f2wEE156dSNFMkvfG8-YZgFfMKOGZp1DEZYow4SnSPDlAnowY1wxZkcwMJw9HpDfG_Uk42Tvqy4r2Bc-dspg5Zf5rtZXzmXC3OjE3GcaahTNMQneeKfcYnOhv1iPbQr3-CeOQWo9djWcBigJC6-GdQKNn5HaSfpzo0rCt68O2Qx3Dqk9BM8Cmx2dm6XdYdKiT3AOe7jk42zBG2Kmf7AIcyfISNIebnvgVmOlMw2S9sg7e8KsqJKwUHKXWUAMO7KwfjGVRLGFewqT2UV1CswELe9IIqlf5EsbwJ1-sl8iK42RWr1RmW9_oVGFsjhwqq1l6Dcbd9--4hzaHKCChmRlDGVacS8JIypSnuJSBz5kQEus6QkhKCKe-ynyhYd_DKfUlFqFhKVREjPpEBDegUValvAMQM79tilhCQ4WlTqsimGt8U5ibBi5pgds6XtN57ZQx3Ya0BaKDSO4uMObWhys659bkepPj-3_f-QKayVt3-vkxGjyAU5PtWrf3CBqrxVo-aS6x4s_2rfkDws7INA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Putative+Role+of+Natural+Killer+Cells+in+Patients+with+Hepatitis+C+Virus-Related+Hepatocellular+Carcinoma&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.au=Hassona%2C+Mona+M&rft.au=Radwan%2C+Enas+M&rft.au=Abdelsameea%2C+Eman&rft.au=Estaphan%2C+Suzanne&rft.date=2021-08-01&rft.pub=West+Asia+Organization+for+Cancer+Prevention&rft.issn=1513-7368&rft.eissn=2476-762X&rft.volume=22&rft.issue=8&rft.spage=2559&rft.epage=2567&rft_id=info:doi/10.31557%2FAPJCP.2021.22.8.2559&rft_id=info%3Apmid%2F34452571&rft.externalDBID=PMC8629465 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1513-7368&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1513-7368&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1513-7368&client=summon |