The alternative sigma factor σ X mediates competence shut-off at the cell pole in Streptococcus pneumoniae

• Published in: eLife Vol. 9
• Main Authors: Johnston, Calum Hg, Soulet, Anne-Lise, Bergé, Matthieu, Prudhomme, Marc, De Lemos, David, Polard, Patrice
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publication 02.11.2020; eLife Sciences Publications, Ltd; eLife Sciences Publications Ltd
• Subjects: alternative sigma factor; bacterial competence regulation; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Biochemistry, Molecular Biology; Gene Expression Regulation, Bacterial - physiology; genetic regulatory networks; Genomics; Life Sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Microbiology and Infectious Disease; Microbiology and Parasitology; Microscopy, Fluorescence; polar competence hub; Sigma Factor - genetics; Sigma Factor - metabolism; streptococcus pneumoniae; Streptococcus pneumoniae - cytology; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - metabolism; Transformation, Genetic; alternative sigma factor; genetic regulatory networks; infectious disease; microbiology; streptococcus pneumoniae; bacterial competence regulation; polar competence hub

Competence is a widespread bacterial differentiation program driving antibiotic resistance and virulence in many pathogens. Here, we studied the spatiotemporal localization dynamics of the key regulators that master the two intertwined and transient transcription waves defining competence in . The f...