Genetic risk scores associated with baseline lipoprotein subfraction concentrations do not associate with their responses to fenofibrate

• Published in: Biology (Basel, Switzerland) Vol. 3; no. 3; pp. 536 - 550
• Main Authors: Frazier-Wood, Alexis C, Wojczynski, Mary K, Borecki, Ingrid B, Hopkins, Paul N, Lai, Chao-Qiang, Ordovas, Jose M, Straka, Robert J, Tsai, Micheal Y, Tiwari, Hemant K, Arnett, Donna K
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 25.08.2014; MDPI AG
• Subjects: candidate gene study; fenofibrate; genetic risk score; GOLDN; HDL size; LDL size; lipoprotein; NMR; particle size; pharmacogenetics

Lipoprotein subclass concentrations are modifiable markers of cardiovascular disease risk. Fenofibrate is known to show beneficial effects on lipoprotein subclasses, but little is known about the role of genetics in mediating the responses of lipoprotein subclasses to fenofibrate. A recent genomewid...