Inulin alleviates acute alcoholism in mice by enhancing ethanol metabolism and regulating the intestinal flora

Inulin, a recognized prebiotic with diverse biological activities, has not yet been reported for its potential in treating alcoholism. Therefore, this study investigated the antialcoholic effects of short, long, and phosphorylated long‐chain inulin and the possible mechanisms. An acute alcoholic int...

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Published ineFood (Amsterdam) Vol. 5; no. 3
Main Authors Bai, Zhouya, Lan, Honglin, Luo, Denglin, Li, Xingguo, Zhang, Yunhui, Geng, Mengyuan, Chang, Shaohe
Format Journal Article
LanguageEnglish
Published Wiley 01.06.2024
Subjects
acute alcoholism
antialcohol effect
ethanol metabolism
Hovenia dulcis Thunb
intestinal flora
inulin
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Abstract Inulin, a recognized prebiotic with diverse biological activities, has not yet been reported for its potential in treating alcoholism. Therefore, this study investigated the antialcoholic effects of short, long, and phosphorylated long‐chain inulin and the possible mechanisms. An acute alcoholic intoxication mice model was established, with the water extract of Hovenia dulcis Thunb serving as a positive control. The different inulins were used for intervention, and the drunkenness of the mice was observed by an animal behavior experiment. The serum liver function indexes (TP, ALB, GLB, ALT, and ALP), as well as the activity of ethanol metabolizing enzymes (ADH and ALDH) in the liver were measured, and the changes in intestinal flora were analyzed. The results showed that short‐chain inulin could alleviate acute alcoholism by activating ethanol metabolizing enzyme activity and improving intestinal flora, and it had a potential protective effect on acute alcoholic liver injury in mice. Short‐chain inulin could alleviate acute alcoholism by activating ethanol metabolizing enzyme activity and improving intestinal flora, and it had a potential protective effect on acute alcoholic liver injury in mice. Highlights Short‐chain inulin can reduce the rate of drunkenness, mortality, and shorten the sober time. Short‐chain inulin can improve acute alcoholism and liver injury. Short‐chain inulin activated ethanol metabolizing enzyme activity. Short‐chain inulin could improve the intestinal flora structure of mice with acute alcoholism.
AbstractList Abstract Inulin, a recognized prebiotic with diverse biological activities, has not yet been reported for its potential in treating alcoholism. Therefore, this study investigated the antialcoholic effects of short, long, and phosphorylated long‐chain inulin and the possible mechanisms. An acute alcoholic intoxication mice model was established, with the water extract of Hovenia dulcis Thunb serving as a positive control. The different inulins were used for intervention, and the drunkenness of the mice was observed by an animal behavior experiment. The serum liver function indexes (TP, ALB, GLB, ALT, and ALP), as well as the activity of ethanol metabolizing enzymes (ADH and ALDH) in the liver were measured, and the changes in intestinal flora were analyzed. The results showed that short‐chain inulin could alleviate acute alcoholism by activating ethanol metabolizing enzyme activity and improving intestinal flora, and it had a potential protective effect on acute alcoholic liver injury in mice.
Abstract Inulin, a recognized prebiotic with diverse biological activities, has not yet been reported for its potential in treating alcoholism. Therefore, this study investigated the antialcoholic effects of short, long, and phosphorylated long‐chain inulin and the possible mechanisms. An acute alcoholic intoxication mice model was established, with the water extract of Hovenia dulcis Thunb serving as a positive control. The different inulins were used for intervention, and the drunkenness of the mice was observed by an animal behavior experiment. The serum liver function indexes (TP, ALB, GLB, ALT, and ALP), as well as the activity of ethanol metabolizing enzymes (ADH and ALDH) in the liver were measured, and the changes in intestinal flora were analyzed. The results showed that short‐chain inulin could alleviate acute alcoholism by activating ethanol metabolizing enzyme activity and improving intestinal flora, and it had a potential protective effect on acute alcoholic liver injury in mice. Highlights Short‐chain inulin can reduce the rate of drunkenness, mortality, and shorten the sober time. Short‐chain inulin can improve acute alcoholism and liver injury. Short‐chain inulin activated ethanol metabolizing enzyme activity. Short‐chain inulin could improve the intestinal flora structure of mice with acute alcoholism.
Inulin, a recognized prebiotic with diverse biological activities, has not yet been reported for its potential in treating alcoholism. Therefore, this study investigated the antialcoholic effects of short, long, and phosphorylated long‐chain inulin and the possible mechanisms. An acute alcoholic intoxication mice model was established, with the water extract of Hovenia dulcis Thunb serving as a positive control. The different inulins were used for intervention, and the drunkenness of the mice was observed by an animal behavior experiment. The serum liver function indexes (TP, ALB, GLB, ALT, and ALP), as well as the activity of ethanol metabolizing enzymes (ADH and ALDH) in the liver were measured, and the changes in intestinal flora were analyzed. The results showed that short‐chain inulin could alleviate acute alcoholism by activating ethanol metabolizing enzyme activity and improving intestinal flora, and it had a potential protective effect on acute alcoholic liver injury in mice. Short‐chain inulin could alleviate acute alcoholism by activating ethanol metabolizing enzyme activity and improving intestinal flora, and it had a potential protective effect on acute alcoholic liver injury in mice. Highlights Short‐chain inulin can reduce the rate of drunkenness, mortality, and shorten the sober time. Short‐chain inulin can improve acute alcoholism and liver injury. Short‐chain inulin activated ethanol metabolizing enzyme activity. Short‐chain inulin could improve the intestinal flora structure of mice with acute alcoholism.
Author Chang, Shaohe
Lan, Honglin
Bai, Zhouya
Zhang, Yunhui
Geng, Mengyuan
Li, Xingguo
Luo, Denglin
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Snippet Inulin, a recognized prebiotic with diverse biological activities, has not yet been reported for its potential in treating alcoholism. Therefore, this study...
Abstract Inulin, a recognized prebiotic with diverse biological activities, has not yet been reported for its potential in treating alcoholism. Therefore, this...
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wiley
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SubjectTerms acute alcoholism
antialcohol effect
ethanol metabolism
Hovenia dulcis Thunb
intestinal flora
inulin
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Title Inulin alleviates acute alcoholism in mice by enhancing ethanol metabolism and regulating the intestinal flora
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fefd2.152
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