Theophylline and diaphragmatic contractility. Investigation of a dose-response relationship

• Published in: The American review of respiratory disease Vol. 138; no. 6; p. 1532
• Main Authors: Foxworth, J W, Reisz, G R, Knudson, S M, Cuddy, P G, Pyszczynski, D R, Emory, C E
• Format: Journal Article
• Language: English
• Published: United States 01.12.1988
• Subjects: Clinical Trials as Topic; Diaphragm - drug effects; Diaphragm - physiopathology; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lung Diseases, Obstructive - blood; Lung Diseases, Obstructive - drug therapy; Lung Diseases, Obstructive - physiopathology; Muscle Contraction - drug effects; Placebos; Random Allocation; Theophylline - blood; Theophylline - therapeutic use

Our study evaluated whether a dose-response relationship exists for theophylline and diaphragmatic contractility within the usual therapeutic range for theophylline. The study, involving 16 patients with mild to moderate chronic obstructive pulmonary disease, was done in a randomized, placebo-contro...