Theophylline and diaphragmatic contractility. Investigation of a dose-response relationship
Our study evaluated whether a dose-response relationship exists for theophylline and diaphragmatic contractility within the usual therapeutic range for theophylline. The study, involving 16 patients with mild to moderate chronic obstructive pulmonary disease, was done in a randomized, placebo-contro...
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| Published in | The American review of respiratory disease Vol. 138; no. 6; p. 1532 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.12.1988
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| Subjects | |
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| Abstract | Our study evaluated whether a dose-response relationship exists for theophylline and diaphragmatic contractility within the usual therapeutic range for theophylline. The study, involving 16 patients with mild to moderate chronic obstructive pulmonary disease, was done in a randomized, placebo-controlled, double-blind, crossover fashion. We found no statistically significant effect of theophylline on diaphragmatic contractility at mean theophylline concentrations of 5.13, 12.07, and 18.6 micrograms/ml. |
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| AbstractList | Our study evaluated whether a dose-response relationship exists for theophylline and diaphragmatic contractility within the usual therapeutic range for theophylline. The study, involving 16 patients with mild to moderate chronic obstructive pulmonary disease, was done in a randomized, placebo-controlled, double-blind, crossover fashion. We found no statistically significant effect of theophylline on diaphragmatic contractility at mean theophylline concentrations of 5.13, 12.07, and 18.6 micrograms/ml. |
| Author | Reisz, G R Pyszczynski, D R Emory, C E Foxworth, J W Knudson, S M Cuddy, P G |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3059899$$D View this record in MEDLINE/PubMed |
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| Snippet | Our study evaluated whether a dose-response relationship exists for theophylline and diaphragmatic contractility within the usual therapeutic range for... |
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| SubjectTerms | Clinical Trials as Topic Diaphragm - drug effects Diaphragm - physiopathology Dose-Response Relationship, Drug Double-Blind Method Humans Lung Diseases, Obstructive - blood Lung Diseases, Obstructive - drug therapy Lung Diseases, Obstructive - physiopathology Muscle Contraction - drug effects Placebos Random Allocation Theophylline - blood Theophylline - therapeutic use |
| Title | Theophylline and diaphragmatic contractility. Investigation of a dose-response relationship |
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