Theophylline and diaphragmatic contractility. Investigation of a dose-response relationship

Our study evaluated whether a dose-response relationship exists for theophylline and diaphragmatic contractility within the usual therapeutic range for theophylline. The study, involving 16 patients with mild to moderate chronic obstructive pulmonary disease, was done in a randomized, placebo-contro...

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Bibliographic Details
Published inThe American review of respiratory disease Vol. 138; no. 6; p. 1532
Main Authors Foxworth, J W, Reisz, G R, Knudson, S M, Cuddy, P G, Pyszczynski, D R, Emory, C E
Format Journal Article
LanguageEnglish
Published United States 01.12.1988
Subjects
Clinical Trials as Topic
Diaphragm - drug effects
Diaphragm - physiopathology
Dose-Response Relationship, Drug
Double-Blind Method
Humans
Lung Diseases, Obstructive - blood
Lung Diseases, Obstructive - drug therapy
Lung Diseases, Obstructive - physiopathology
Muscle Contraction - drug effects
Placebos
Random Allocation
Theophylline - blood
Theophylline - therapeutic use
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Summary:Our study evaluated whether a dose-response relationship exists for theophylline and diaphragmatic contractility within the usual therapeutic range for theophylline. The study, involving 16 patients with mild to moderate chronic obstructive pulmonary disease, was done in a randomized, placebo-controlled, double-blind, crossover fashion. We found no statistically significant effect of theophylline on diaphragmatic contractility at mean theophylline concentrations of 5.13, 12.07, and 18.6 micrograms/ml.
ISSN:0003-0805
DOI:10.1164/ajrccm/138.6.1532