Translating preclinical models to humans

• Published in: Science (American Association for the Advancement of Science) Vol. 367; no. 6479; pp. 742 - 743
• Main Authors: Brubaker, Douglas K., Lauffenburger, Douglas A.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 14.02.2020
• Subjects: Animal models; Animals; Biology; Clinical trials; Computer applications; Computer Simulation; Drug Development; Experiments; Human performance; Humans; Learning algorithms; Machine Learning; Mathematical models; Models, Animal; Primates; Rodentia; Translation; Translational Research, Biomedical

Computational models for cross-species translation could improve drug development Generalizing results from animal models to human patients is a critical biomedical challenge. This problem is a key cause of the large proportion of failures encountered in moving therapeutics from preclinical studies...