Multivalent mesoporous silica nanoparticles photo-delivering nitric oxide with carbon dots as fluorescence reporters

Amino-terminated mesoporous silica nanoparticles embedding carbon dots (MSCD) formed by calcination were functionalized with a nitric oxide (NO) photodonor (1) to give a robust MSCD-1 conjugate. The intense fluorescence of MSCDs was strongly quenched in MSCD-1 by effective energy transfer. Visible l...

Full description

Saved in:
Bibliographic Details
Published inNanoscale Vol. 9; no. 36; pp. 13404 - 13408
Main Authors Afonso, Damien, Valetti, Sabrina, Fraix, Aurore, Bascetta, Claudia, Petralia, Salvatore, Conoci, Sabrina, Feiler, Adam, Sortino, Salvatore
Format Journal Article
LanguageEnglish
Published England 28.09.2017
Online AccessGet full text

Cover

More Information
Summary:Amino-terminated mesoporous silica nanoparticles embedding carbon dots (MSCD) formed by calcination were functionalized with a nitric oxide (NO) photodonor (1) to give a robust MSCD-1 conjugate. The intense fluorescence of MSCDs was strongly quenched in MSCD-1 by effective energy transfer. Visible light excitation of MSCD-1 liberates NO, suppresses the energy transfer mechanism and leads to concomitant fluorescence restoration of the MSCD scaffold, which acts as an optical reporter for the released NO. The MSCD-1 hybrid is also able to encapsulate the highly hydrophobic photosensitizer temoporfin, preserving the fluorescence reporting function.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2040-3364
2040-3372
2040-3372
DOI:10.1039/c7nr04832g