Microneedle array with a pH-responsive polymer coating and its application in smart drug delivery for wound healing
•A new approach to prepare smart microneedles through easy, quick and cheaper method.•Porous polymer coatings on microneedles (MNs) provide automatic release of therapeutics in response to wound pH conditions.•Wound pH-sensitive drug release both in vivo and in vitro with rapid sensitivity. For succ...
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Published in | Sensors and actuators. B, Chemical Vol. 345; p. 130441 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Lausanne
Elsevier B.V
15.10.2021
Elsevier Science Ltd |
Subjects | |
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Abstract | •A new approach to prepare smart microneedles through easy, quick and cheaper method.•Porous polymer coatings on microneedles (MNs) provide automatic release of therapeutics in response to wound pH conditions.•Wound pH-sensitive drug release both in vivo and in vitro with rapid sensitivity.
For successful wound treatment, therapeutics must be delivered directly to the wound. Various issues restrict the delivery of antibiotics to wounds, including the barrier mannered by necrotic tissue and biofilms, which create an extracellular polymeric layer that impedes the efficient administration of therapeutics. For achieving break of the necrotic tissue barrier and biofilm, in addition, improving antibiotics penetration through a painless administration, we fabricated porous polymer coatings on microneedles (MNs) which had the ability of automatic “release” therapeutics in response to wound pH conditions. In the pores of the porous polymer film, the model drug was packed using aqueous gelatin porogen, and the porous layer was coated with a Eudragit S100 film to cap the pores to prevent drug leakage and provide a wound pH-responsive drug release. By combining the advantages of porous and pH-responsive polymer coatings, the coated MNs exhibited remarkably enhanced therapeutic results. This formulation showed both in vivo (in rats) and in vitro (in phosphate-buffered saline and in porcine skin) wound pH-sensitive drug release with rapid responsiveness. At healthy skin pH (pH 4.5), an insignificant release was noticed for MNs in the test media. However, drug release considerably increased when MNs were exposed to wound pH conditions (pH 7.5). The present study provides proof-of-concept evidence that developed MNs have the potential of enhanced treatment protocol for wound infections with the flexibility of coating materials and antimicrobials and offers significant scope for further variations and advancement. |
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AbstractList | •A new approach to prepare smart microneedles through easy, quick and cheaper method.•Porous polymer coatings on microneedles (MNs) provide automatic release of therapeutics in response to wound pH conditions.•Wound pH-sensitive drug release both in vivo and in vitro with rapid sensitivity.
For successful wound treatment, therapeutics must be delivered directly to the wound. Various issues restrict the delivery of antibiotics to wounds, including the barrier mannered by necrotic tissue and biofilms, which create an extracellular polymeric layer that impedes the efficient administration of therapeutics. For achieving break of the necrotic tissue barrier and biofilm, in addition, improving antibiotics penetration through a painless administration, we fabricated porous polymer coatings on microneedles (MNs) which had the ability of automatic “release” therapeutics in response to wound pH conditions. In the pores of the porous polymer film, the model drug was packed using aqueous gelatin porogen, and the porous layer was coated with a Eudragit S100 film to cap the pores to prevent drug leakage and provide a wound pH-responsive drug release. By combining the advantages of porous and pH-responsive polymer coatings, the coated MNs exhibited remarkably enhanced therapeutic results. This formulation showed both in vivo (in rats) and in vitro (in phosphate-buffered saline and in porcine skin) wound pH-sensitive drug release with rapid responsiveness. At healthy skin pH (pH 4.5), an insignificant release was noticed for MNs in the test media. However, drug release considerably increased when MNs were exposed to wound pH conditions (pH 7.5). The present study provides proof-of-concept evidence that developed MNs have the potential of enhanced treatment protocol for wound infections with the flexibility of coating materials and antimicrobials and offers significant scope for further variations and advancement. For successful wound treatment, therapeutics must be delivered directly to the wound. Various issues restrict the delivery of antibiotics to wounds, including the barrier mannered by necrotic tissue and biofilms, which create an extracellular polymeric layer that impedes the efficient administration of therapeutics. For achieving break of the necrotic tissue barrier and biofilm, in addition, improving antibiotics penetration through a painless administration, we fabricated porous polymer coatings on microneedles (MNs) which had the ability of automatic "release" therapeutics in response to wound pH conditions. In the pores of the porous polymer film, the model drug was packed using aqueous gelatin porogen, and the porous layer was coated with a Eudragit S100 film to cap the pores to prevent drug leakage and provide a wound pH-responsive drug release. By combining the advantages of porous and pH-responsive polymer coatings, the coated MNs exhibited remarkably enhanced therapeutic results. This formulation showed both in vivo (in rats) and in vitro (in phosphate-buffered saline and in porcine skin) wound pH-sensitive drug release with rapid responsiveness. At healthy skin pH (pH 4.5), an insignificant release was noticed for MNs in the test media. However, drug release considerably increased when MNs were exposed to wound pH conditions (pH 7.5). The present study provides proof-of-concept evidence that developed MNs have the potential of enhanced treatment protocol for wound infections with the flexibility of coating materials and antimicrobials and offers significant scope for further variations and advancement. |
ArticleNumber | 130441 |
Author | Choi, Hye Jin Kim, Gyu Man Kim, Ye-Ri Jang, Mijin Khan, Haroon Kim, Un-Kyung Ullah, Asad An, Sanghyun Kim, Dongseon |
Author_xml | – sequence: 1 givenname: Asad orcidid: 0000-0002-4390-1744 surname: Ullah fullname: Ullah, Asad organization: School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea – sequence: 2 givenname: Mijin surname: Jang fullname: Jang, Mijin organization: Daegu Gyeongbuk Medical Innovation Foundation, Laboratory Animal Center, Daegu, 41061, South Korea – sequence: 3 givenname: Haroon surname: Khan fullname: Khan, Haroon organization: School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea – sequence: 4 givenname: Hye Jin surname: Choi fullname: Choi, Hye Jin organization: School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea – sequence: 5 givenname: Sanghyun surname: An fullname: An, Sanghyun organization: Daegu Gyeongbuk Medical Innovation Foundation, Laboratory Animal Center, Daegu, 41061, South Korea – sequence: 6 givenname: Dongseon surname: Kim fullname: Kim, Dongseon organization: Daegu Gyeongbuk Medical Innovation Foundation, Laboratory Animal Center, Daegu, 41061, South Korea – sequence: 7 givenname: Ye-Ri surname: Kim fullname: Kim, Ye-Ri organization: Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 14566, South Korea – sequence: 8 givenname: Un-Kyung surname: Kim fullname: Kim, Un-Kyung organization: Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 14566, South Korea – sequence: 9 givenname: Gyu Man surname: Kim fullname: Kim, Gyu Man email: gyuman.kim@knu.ac.kr organization: School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea |
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Cites_doi | 10.1111/j.1524-475X.2007.00321.x 10.1002/jps.24610 10.1111/j.1552-6909.1999.tb01989.x 10.3390/pharmaceutics12070606 10.1002/term.1492 10.1089/dia.2012.0188 10.1002/jps.21210 10.1021/acsnano.6b06892 10.1098/rsos.171609 10.3390/polym11111834 10.1111/wrr.12099 10.1016/S0140-6736(00)02799-9 10.1166/jnn.2017.14838 10.1073/pnas.0812652106 10.1073/pnas.1006945108 10.2174/1389450118666170704132523 10.1002/adhm.201500450 10.1002/adfm.201201512 10.1097/WON.0b013e31822ad034 10.3389/fmicb.2016.00592 10.1039/C7TB02082A 10.1126/scitranslmed.aaw3329 10.1021/acsami.9b02578 10.1016/j.jconrel.2014.03.055 10.1002/adfm.201909197 10.1007/s12325-017-0478-y 10.12968/jowc.1996.5.6.277 10.1007/s40204-018-0083-4 10.1016/j.bios.2012.09.029 10.1016/j.ijpharm.2016.01.044 10.1016/j.ijpharm.2005.10.038 10.1016/j.vaccine.2014.01.076 10.1021/acsbiomaterials.8b00626 10.1021/acsami.6b10491 10.1016/j.molimm.2014.10.023 |
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References | Richmond, Lamel, Davidson, Martins‐Green, Sen, Tomic‐Canic (bib0005) 2013; 21 Xu, Jiang, Yu, Liu, Zhang, Zhou (bib0165) 2017; 5 Mir, Ali, Barakullah, Gulzar, Arshad, Fatima (bib0140) 2018; 7 Bae, Ko, So, Yi, Lee, Lee (bib0105) 2019; 11 Kanda, Morimoto, Ayvazyan, Takemoto, Kawai, Nakamura (bib0150) 2014; 8 Zhu, Zarnitsyn, Ye, Wen, Gao, Pan (bib0180) 2009; 106 Schreml, Meier, Wolfbeis, Landthaler, Szeimies, Babilas (bib0070) 2011; 108 Lund, Kuller, Lane, Lott, Raines (bib0035) 1999; 28 Ullah, Choi, Jang, An, Kim (bib0170) 2020; 12 Han, Ceilley (bib0010) 2017; 34 Boateng, Matthews, Stevens, Eccleston (bib0020) 2008; 97 Norman, Arya, McClain, Frew, Meltzer, Prausnitz (bib0110) 2014; 32 Han, Morde, Mariani, La Mattina, Vignali, Yang (bib0100) 2020; 30 Xu, Cao, Zhang, Yu, Zhu, Liu (bib0125) 2018; 4 Forier, Raemdonck, De Smedt, Demeester, Coenye, Braeckmans (bib0065) 2014; 190 Dargaville, Farrugia, Broadbent, Pace, Upton, Voelcker (bib0025) 2013; 41 Ullah, Kim, Kim (bib0160) 2018; 5 Boateng, Catanzano (bib0015) 2015; 104 Shi, Ramsay, Ermis, Carson (bib0030) 2011; 38 Miquel, Lagrafeuille, Souweine, Forestier (bib0080) 2016; 7 Ninan, Forget, Shastri, Voelcker, Blencowe (bib0050) 2016; 8 El-Laboudi, Oliver, Cass, Johnston (bib0095) 2013; 15 Jin, Yousaf, Kim, Kim, Kim, Kim (bib0175) 2016; 501 Xu, Danehy, Cai, Ao, Pu, Nusawardhana (bib0055) 2019; 11 Ullah, Kim, Kim (bib0130) 2017; 17 Hussain, Thu, Shuid, Katas, Hussain (bib0145) 2018; 19 Ullah, Khan, Choi, Kim (bib0135) 2019; 11 Garg, Singh, Goyal (bib0060) 2013; 30 Summerfield, Meurens, Ricklin (bib0185) 2015; 66 Edwards, Aronson (bib0075) 2000; 356 James, Swogger, Wolcott, Pulcini, Secor, Sestrich (bib0045) 2008; 16 Mostafalu, Tamayol, Rahimi, Ochoa, Khalilpour, Kiaee (bib0085) 2018; 14 Ibekwe, Fadda, Parsons, Basit (bib0155) 2006; 308 Trengove, Stacey, McGechie, Stingemore, Mata (bib0040) 1996; 5 Hu, Yu, Qian, Lu, Kahkoska, Xie (bib0120) 2017; 11 DeMuth, Garcia‐Beltran, Ai‐Ling, Hammond, Irvine (bib0090) 2013; 23 Ventrelli, Marsilio Strambini, Barillaro (bib0115) 2015; 4 El-Laboudi (10.1016/j.snb.2021.130441_bib0095) 2013; 15 DeMuth (10.1016/j.snb.2021.130441_bib0090) 2013; 23 Han (10.1016/j.snb.2021.130441_bib0010) 2017; 34 Jin (10.1016/j.snb.2021.130441_bib0175) 2016; 501 Shi (10.1016/j.snb.2021.130441_bib0030) 2011; 38 Ibekwe (10.1016/j.snb.2021.130441_bib0155) 2006; 308 Bae (10.1016/j.snb.2021.130441_bib0105) 2019; 11 Ullah (10.1016/j.snb.2021.130441_bib0130) 2017; 17 Trengove (10.1016/j.snb.2021.130441_bib0040) 1996; 5 Xu (10.1016/j.snb.2021.130441_bib0165) 2017; 5 James (10.1016/j.snb.2021.130441_bib0045) 2008; 16 Boateng (10.1016/j.snb.2021.130441_bib0020) 2008; 97 Xu (10.1016/j.snb.2021.130441_bib0125) 2018; 4 Kanda (10.1016/j.snb.2021.130441_bib0150) 2014; 8 Ventrelli (10.1016/j.snb.2021.130441_bib0115) 2015; 4 Ullah (10.1016/j.snb.2021.130441_bib0135) 2019; 11 Richmond (10.1016/j.snb.2021.130441_bib0005) 2013; 21 Ninan (10.1016/j.snb.2021.130441_bib0050) 2016; 8 Edwards (10.1016/j.snb.2021.130441_bib0075) 2000; 356 Forier (10.1016/j.snb.2021.130441_bib0065) 2014; 190 Han (10.1016/j.snb.2021.130441_bib0100) 2020; 30 Norman (10.1016/j.snb.2021.130441_bib0110) 2014; 32 Garg (10.1016/j.snb.2021.130441_bib0060) 2013; 30 Dargaville (10.1016/j.snb.2021.130441_bib0025) 2013; 41 Ullah (10.1016/j.snb.2021.130441_bib0170) 2020; 12 Hussain (10.1016/j.snb.2021.130441_bib0145) 2018; 19 Ullah (10.1016/j.snb.2021.130441_bib0160) 2018; 5 Schreml (10.1016/j.snb.2021.130441_bib0070) 2011; 108 Xu (10.1016/j.snb.2021.130441_bib0055) 2019; 11 Mir (10.1016/j.snb.2021.130441_bib0140) 2018; 7 Zhu (10.1016/j.snb.2021.130441_bib0180) 2009; 106 Boateng (10.1016/j.snb.2021.130441_bib0015) 2015; 104 Lund (10.1016/j.snb.2021.130441_bib0035) 1999; 28 Mostafalu (10.1016/j.snb.2021.130441_bib0085) 2018; 14 Hu (10.1016/j.snb.2021.130441_bib0120) 2017; 11 Summerfield (10.1016/j.snb.2021.130441_bib0185) 2015; 66 Miquel (10.1016/j.snb.2021.130441_bib0080) 2016; 7 |
References_xml | – volume: 356 start-page: 1255 year: 2000 end-page: 1259 ident: bib0075 article-title: Adverse drug reactions: definitions, diagnosis, and management publication-title: Lancet contributor: fullname: Aronson – volume: 11 year: 2019 ident: bib0105 article-title: Snake fang–inspired stamping patch for transdermal delivery of liquid formulations publication-title: Sci. Transl. Med. contributor: fullname: Lee – volume: 4 start-page: 2606 year: 2015 end-page: 2640 ident: bib0115 article-title: Microneedles for transdermal biosensing: current picture and future direction publication-title: Adv. healthcare Mater. contributor: fullname: Barillaro – volume: 501 start-page: 160 year: 2016 end-page: 166 ident: bib0175 article-title: Influence of hydrophilic polymers on functional properties and wound healing efficacy of hydrocolloid based wound dressings publication-title: Int. J. Pharm. contributor: fullname: Kim – volume: 15 start-page: 101 year: 2013 end-page: 115 ident: bib0095 article-title: Use of microneedle array devices for continuous glucose monitoring: a review publication-title: Diabetes Technol. Ther. contributor: fullname: Johnston – volume: 38 start-page: 514 year: 2011 end-page: 521 ident: bib0030 article-title: pH in the bacteria-contaminated wound and its impact on clostridium histolyticum collagenase activity: implications for the use of collagenase wound debridement agents publication-title: J. Wound Ostomy Continence Nurs. contributor: fullname: Carson – volume: 11 start-page: 1936 year: 2017 ident: bib0120 article-title: H2O2-responsive vesicles integrated with transcutaneous patches for glucose-mediated insulin delivery publication-title: ACS nano contributor: fullname: Xie – volume: 30 year: 2013 ident: bib0060 article-title: Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery publication-title: Crit. Rev. TM Ther. Drug Carrier Syst. contributor: fullname: Goyal – volume: 108 start-page: 2432 year: 2011 end-page: 2437 ident: bib0070 article-title: 2D luminescence imaging of pH in vivo publication-title: Proc. Nat. Acad. Sci. contributor: fullname: Babilas – volume: 19 start-page: 527 year: 2018 end-page: 550 ident: bib0145 article-title: Recent advances in polymer-based wound dressings for the treatment of diabetic foot ulcer: an overview of state-of-the-art publication-title: Current Drug Targets contributor: fullname: Hussain – volume: 97 start-page: 2892 year: 2008 end-page: 2923 ident: bib0020 article-title: Wound healing dressings and drug delivery systems: a review publication-title: J. Pharm. Sci. contributor: fullname: Eccleston – volume: 14 year: 2018 ident: bib0085 article-title: Smart bandage for monitoring and treatment of chronic wounds publication-title: Small contributor: fullname: Kiaee – volume: 11 start-page: 14640 year: 2019 end-page: 14646 ident: bib0055 article-title: Microneedle patch-mediated treatment of bacterial biofilms publication-title: ACS Appl. Mater. Interfaces contributor: fullname: Nusawardhana – volume: 7 start-page: 1 year: 2018 end-page: 21 ident: bib0140 article-title: Synthetic polymeric biomaterials for wound healing: a review publication-title: Prog. Biomater. contributor: fullname: Fatima – volume: 7 start-page: 592 year: 2016 ident: bib0080 article-title: Anti-biofilm activity as a health issue publication-title: Front Microbiol contributor: fullname: Forestier – volume: 5 start-page: 8200 year: 2017 end-page: 8208 ident: bib0165 article-title: H 2 O 2-responsive mesoporous silica nanoparticles integrated with microneedle patches for the glucose-monitored transdermal delivery of insulin publication-title: J. Mater. Chem. B contributor: fullname: Zhou – volume: 32 start-page: 1856 year: 2014 end-page: 1862 ident: bib0110 article-title: Microneedle patches: usability and acceptability for self-vaccination against influenza publication-title: Vaccine contributor: fullname: Prausnitz – volume: 11 start-page: 1834 year: 2019 ident: bib0135 article-title: Smart microneedles with porous polymer coatings for pH-Responsive drug delivery publication-title: Polymers contributor: fullname: Kim – volume: 5 year: 2018 ident: bib0160 article-title: Porous polymer coatings on metal microneedles for enhanced drug delivery publication-title: R. Soc. Open Sci. contributor: fullname: Kim – volume: 66 start-page: 14 year: 2015 end-page: 21 ident: bib0185 article-title: The immunology of the porcine skin and its value as a model for human skin publication-title: Mol. Immunol. contributor: fullname: Ricklin – volume: 5 start-page: 277 year: 1996 end-page: 280 ident: bib0040 article-title: Qualitative bacteriology and leg ulcer healing publication-title: J. Wound Care contributor: fullname: Mata – volume: 106 start-page: 7968 year: 2009 end-page: 7973 ident: bib0180 article-title: Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge publication-title: Proc. Natl. Acad. Sci. contributor: fullname: Pan – volume: 28 start-page: 241 year: 1999 end-page: 254 ident: bib0035 article-title: Neonatal skin care: the scientific basis for practice publication-title: J. Obstetric, Gynecologic, Neonatal Nurs. contributor: fullname: Raines – volume: 4 start-page: 2473 year: 2018 end-page: 2483 ident: bib0125 article-title: Microneedles integrated with ZnO quantum-dot-capped mesoporous bioactive glasses for glucose-mediated insulin delivery publication-title: ACS Biomater. Sci. Eng. contributor: fullname: Liu – volume: 41 start-page: 30 year: 2013 end-page: 42 ident: bib0025 article-title: Sensors and imaging for wound healing: a review publication-title: Biosens. Bioelectron. contributor: fullname: Voelcker – volume: 23 start-page: 161 year: 2013 end-page: 172 ident: bib0090 article-title: Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination publication-title: Adv. Funct. Mater. contributor: fullname: Irvine – volume: 8 start-page: 29 year: 2014 end-page: 40 ident: bib0150 article-title: Evaluation of a novel collagen–gelatin scaffold for achieving the sustained release of basic fibroblast growth factor in a diabetic mouse model publication-title: J. tissue Eng. Regener. Med. contributor: fullname: Nakamura – volume: 104 start-page: 3653 year: 2015 end-page: 3680 ident: bib0015 article-title: Advanced therapeutic dressings for effective wound healing—a review publication-title: J. Pharm. Sci. contributor: fullname: Catanzano – volume: 16 start-page: 37 year: 2008 end-page: 44 ident: bib0045 article-title: Biofilms in chronic wounds publication-title: Wound Repair Regener. contributor: fullname: Sestrich – volume: 34 start-page: 599 year: 2017 end-page: 610 ident: bib0010 article-title: Chronic wound healing: a review of current management and treatments publication-title: Adv. Ther. contributor: fullname: Ceilley – volume: 190 start-page: 607 year: 2014 end-page: 623 ident: bib0065 article-title: Lipid and polymer nanoparticles for drug delivery to bacterial biofilms publication-title: J. Controlled Release contributor: fullname: Braeckmans – volume: 21 start-page: 789 year: 2013 end-page: 792 ident: bib0005 article-title: US–National Institutes of Health‐funded research for cutaneous wounds in 2012 publication-title: Wound Repair Regen. contributor: fullname: Tomic‐Canic – volume: 17 start-page: 7775 year: 2017 end-page: 7782 ident: bib0130 article-title: Solvent effects on the porosity and size of porous PLGA microspheres using gelatin and PBS as porogens in a microfluidic flow-focusing device publication-title: J. Nanosci. Nanotechnol. contributor: fullname: Kim – volume: 12 start-page: 606 year: 2020 ident: bib0170 article-title: Smart microneedles with porous polymer layer for glucose-responsive insulin delivery publication-title: Pharmaceutics contributor: fullname: Kim – volume: 30 year: 2020 ident: bib0100 article-title: 4D printing of a bioinspired microneedle array with backward‐facing barbs for enhanced tissue adhesion publication-title: Adv. Funct. Mater. contributor: fullname: Yang – volume: 8 start-page: 28511 year: 2016 end-page: 28521 ident: bib0050 article-title: Antibacterial and anti-inflammatory pH-responsive tannic acid-carboxylated agarose composite hydrogels for wound healing publication-title: ACS Appl. Mater. Interfaces contributor: fullname: Blencowe – volume: 308 start-page: 0378 year: 2006 end-page: 5173 ident: bib0155 article-title: A comparative in vitro assessment of the drug release performance of pH-responsive polymers for ileo-colonic delivery publication-title: Int. J. Pharm. contributor: fullname: Basit – volume: 16 start-page: 37 year: 2008 ident: 10.1016/j.snb.2021.130441_bib0045 article-title: Biofilms in chronic wounds publication-title: Wound Repair Regener. doi: 10.1111/j.1524-475X.2007.00321.x contributor: fullname: James – volume: 104 start-page: 3653 year: 2015 ident: 10.1016/j.snb.2021.130441_bib0015 article-title: Advanced therapeutic dressings for effective wound healing—a review publication-title: J. Pharm. Sci. doi: 10.1002/jps.24610 contributor: fullname: Boateng – volume: 28 start-page: 241 year: 1999 ident: 10.1016/j.snb.2021.130441_bib0035 article-title: Neonatal skin care: the scientific basis for practice publication-title: J. Obstetric, Gynecologic, Neonatal Nurs. doi: 10.1111/j.1552-6909.1999.tb01989.x contributor: fullname: Lund – volume: 14 year: 2018 ident: 10.1016/j.snb.2021.130441_bib0085 article-title: Smart bandage for monitoring and treatment of chronic wounds publication-title: Small contributor: fullname: Mostafalu – volume: 12 start-page: 606 year: 2020 ident: 10.1016/j.snb.2021.130441_bib0170 article-title: Smart microneedles with porous polymer layer for glucose-responsive insulin delivery publication-title: Pharmaceutics doi: 10.3390/pharmaceutics12070606 contributor: fullname: Ullah – volume: 8 start-page: 29 year: 2014 ident: 10.1016/j.snb.2021.130441_bib0150 article-title: Evaluation of a novel collagen–gelatin scaffold for achieving the sustained release of basic fibroblast growth factor in a diabetic mouse model publication-title: J. tissue Eng. Regener. Med. doi: 10.1002/term.1492 contributor: fullname: Kanda – volume: 15 start-page: 101 year: 2013 ident: 10.1016/j.snb.2021.130441_bib0095 article-title: Use of microneedle array devices for continuous glucose monitoring: a review publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2012.0188 contributor: fullname: El-Laboudi – volume: 97 start-page: 2892 year: 2008 ident: 10.1016/j.snb.2021.130441_bib0020 article-title: Wound healing dressings and drug delivery systems: a review publication-title: J. Pharm. Sci. doi: 10.1002/jps.21210 contributor: fullname: Boateng – volume: 11 start-page: 1936 year: 2017 ident: 10.1016/j.snb.2021.130441_bib0120 article-title: H2O2-responsive vesicles integrated with transcutaneous patches for glucose-mediated insulin delivery publication-title: ACS nano doi: 10.1021/acsnano.6b06892 contributor: fullname: Hu – volume: 5 year: 2018 ident: 10.1016/j.snb.2021.130441_bib0160 article-title: Porous polymer coatings on metal microneedles for enhanced drug delivery publication-title: R. Soc. Open Sci. doi: 10.1098/rsos.171609 contributor: fullname: Ullah – volume: 11 start-page: 1834 year: 2019 ident: 10.1016/j.snb.2021.130441_bib0135 article-title: Smart microneedles with porous polymer coatings for pH-Responsive drug delivery publication-title: Polymers doi: 10.3390/polym11111834 contributor: fullname: Ullah – volume: 21 start-page: 789 year: 2013 ident: 10.1016/j.snb.2021.130441_bib0005 article-title: US–National Institutes of Health‐funded research for cutaneous wounds in 2012 publication-title: Wound Repair Regen. doi: 10.1111/wrr.12099 contributor: fullname: Richmond – volume: 356 start-page: 1255 year: 2000 ident: 10.1016/j.snb.2021.130441_bib0075 article-title: Adverse drug reactions: definitions, diagnosis, and management publication-title: Lancet doi: 10.1016/S0140-6736(00)02799-9 contributor: fullname: Edwards – volume: 17 start-page: 7775 year: 2017 ident: 10.1016/j.snb.2021.130441_bib0130 article-title: Solvent effects on the porosity and size of porous PLGA microspheres using gelatin and PBS as porogens in a microfluidic flow-focusing device publication-title: J. Nanosci. Nanotechnol. doi: 10.1166/jnn.2017.14838 contributor: fullname: Ullah – volume: 106 start-page: 7968 year: 2009 ident: 10.1016/j.snb.2021.130441_bib0180 article-title: Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.0812652106 contributor: fullname: Zhu – volume: 108 start-page: 2432 year: 2011 ident: 10.1016/j.snb.2021.130441_bib0070 article-title: 2D luminescence imaging of pH in vivo publication-title: Proc. Nat. Acad. Sci. doi: 10.1073/pnas.1006945108 contributor: fullname: Schreml – volume: 19 start-page: 527 year: 2018 ident: 10.1016/j.snb.2021.130441_bib0145 article-title: Recent advances in polymer-based wound dressings for the treatment of diabetic foot ulcer: an overview of state-of-the-art publication-title: Current Drug Targets doi: 10.2174/1389450118666170704132523 contributor: fullname: Hussain – volume: 4 start-page: 2606 year: 2015 ident: 10.1016/j.snb.2021.130441_bib0115 article-title: Microneedles for transdermal biosensing: current picture and future direction publication-title: Adv. healthcare Mater. doi: 10.1002/adhm.201500450 contributor: fullname: Ventrelli – volume: 30 year: 2013 ident: 10.1016/j.snb.2021.130441_bib0060 article-title: Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery publication-title: Crit. Rev. TM Ther. Drug Carrier Syst. contributor: fullname: Garg – volume: 23 start-page: 161 year: 2013 ident: 10.1016/j.snb.2021.130441_bib0090 article-title: Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201201512 contributor: fullname: DeMuth – volume: 38 start-page: 514 year: 2011 ident: 10.1016/j.snb.2021.130441_bib0030 article-title: pH in the bacteria-contaminated wound and its impact on clostridium histolyticum collagenase activity: implications for the use of collagenase wound debridement agents publication-title: J. Wound Ostomy Continence Nurs. doi: 10.1097/WON.0b013e31822ad034 contributor: fullname: Shi – volume: 7 start-page: 592 year: 2016 ident: 10.1016/j.snb.2021.130441_bib0080 article-title: Anti-biofilm activity as a health issue publication-title: Front Microbiol doi: 10.3389/fmicb.2016.00592 contributor: fullname: Miquel – volume: 5 start-page: 8200 year: 2017 ident: 10.1016/j.snb.2021.130441_bib0165 article-title: H 2 O 2-responsive mesoporous silica nanoparticles integrated with microneedle patches for the glucose-monitored transdermal delivery of insulin publication-title: J. Mater. Chem. B doi: 10.1039/C7TB02082A contributor: fullname: Xu – volume: 11 year: 2019 ident: 10.1016/j.snb.2021.130441_bib0105 article-title: Snake fang–inspired stamping patch for transdermal delivery of liquid formulations publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaw3329 contributor: fullname: Bae – volume: 11 start-page: 14640 year: 2019 ident: 10.1016/j.snb.2021.130441_bib0055 article-title: Microneedle patch-mediated treatment of bacterial biofilms publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.9b02578 contributor: fullname: Xu – volume: 190 start-page: 607 year: 2014 ident: 10.1016/j.snb.2021.130441_bib0065 article-title: Lipid and polymer nanoparticles for drug delivery to bacterial biofilms publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2014.03.055 contributor: fullname: Forier – volume: 30 year: 2020 ident: 10.1016/j.snb.2021.130441_bib0100 article-title: 4D printing of a bioinspired microneedle array with backward‐facing barbs for enhanced tissue adhesion publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201909197 contributor: fullname: Han – volume: 34 start-page: 599 year: 2017 ident: 10.1016/j.snb.2021.130441_bib0010 article-title: Chronic wound healing: a review of current management and treatments publication-title: Adv. Ther. doi: 10.1007/s12325-017-0478-y contributor: fullname: Han – volume: 5 start-page: 277 year: 1996 ident: 10.1016/j.snb.2021.130441_bib0040 article-title: Qualitative bacteriology and leg ulcer healing publication-title: J. Wound Care doi: 10.12968/jowc.1996.5.6.277 contributor: fullname: Trengove – volume: 7 start-page: 1 year: 2018 ident: 10.1016/j.snb.2021.130441_bib0140 article-title: Synthetic polymeric biomaterials for wound healing: a review publication-title: Prog. Biomater. doi: 10.1007/s40204-018-0083-4 contributor: fullname: Mir – volume: 41 start-page: 30 year: 2013 ident: 10.1016/j.snb.2021.130441_bib0025 article-title: Sensors and imaging for wound healing: a review publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2012.09.029 contributor: fullname: Dargaville – volume: 501 start-page: 160 year: 2016 ident: 10.1016/j.snb.2021.130441_bib0175 article-title: Influence of hydrophilic polymers on functional properties and wound healing efficacy of hydrocolloid based wound dressings publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2016.01.044 contributor: fullname: Jin – volume: 308 start-page: 0378 year: 2006 ident: 10.1016/j.snb.2021.130441_bib0155 article-title: A comparative in vitro assessment of the drug release performance of pH-responsive polymers for ileo-colonic delivery publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2005.10.038 contributor: fullname: Ibekwe – volume: 32 start-page: 1856 year: 2014 ident: 10.1016/j.snb.2021.130441_bib0110 article-title: Microneedle patches: usability and acceptability for self-vaccination against influenza publication-title: Vaccine doi: 10.1016/j.vaccine.2014.01.076 contributor: fullname: Norman – volume: 4 start-page: 2473 year: 2018 ident: 10.1016/j.snb.2021.130441_bib0125 article-title: Microneedles integrated with ZnO quantum-dot-capped mesoporous bioactive glasses for glucose-mediated insulin delivery publication-title: ACS Biomater. Sci. Eng. doi: 10.1021/acsbiomaterials.8b00626 contributor: fullname: Xu – volume: 8 start-page: 28511 year: 2016 ident: 10.1016/j.snb.2021.130441_bib0050 article-title: Antibacterial and anti-inflammatory pH-responsive tannic acid-carboxylated agarose composite hydrogels for wound healing publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.6b10491 contributor: fullname: Ninan – volume: 66 start-page: 14 year: 2015 ident: 10.1016/j.snb.2021.130441_bib0185 article-title: The immunology of the porcine skin and its value as a model for human skin publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2014.10.023 contributor: fullname: Summerfield |
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Snippet | •A new approach to prepare smart microneedles through easy, quick and cheaper method.•Porous polymer coatings on microneedles (MNs) provide automatic release... For successful wound treatment, therapeutics must be delivered directly to the wound. Various issues restrict the delivery of antibiotics to wounds, including... |
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SubjectTerms | Antibiotics Automatic release Biofilms Gelatin In vivo methods and tests Microneedles Needles Polymer coatings Polymer films Polymers Porous polymer coating Protective coatings Wound healing Wound pH-responsive |
Title | Microneedle array with a pH-responsive polymer coating and its application in smart drug delivery for wound healing |
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