New Aβ(1–42) ligands from anti-amyloid antibodies: Design, synthesis, and structural interaction

• Published in: European journal of medicinal chemistry Vol. 237; p. 114400
• Main Authors: Santoro, Angelo, Grimaldi, Manuela, Buonocore, Michela, Stillitano, Ilaria, Gloria, Antonio, Santin, Matteo, Bobba, Fabrizio, Sublimi Saponetti, Matilde, Ciaglia, Elena, D'Ursi, Anna Maria
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 05.07.2022
• Subjects: Alzheimer; Alzheimer Disease - metabolism; Amyloid - chemistry; Amyloid beta-Peptides - chemistry; Amyloid plaques; Amyloidosis; Antibodies - chemistry; Antibody; Aptamers; Biomarkers; Humans; Immunotherapy; Ligands; Peptide design; Peptide Fragments - chemistry; Peptide design; Antibody; Immunotherapy; Aptamers; Biomarkers; Alzheimer; Amyloid plaques

Alzheimer's disease (AD), is the most common neurodegenerative disorder of the aging population resulting in progressive cognitive and functional decline. Accumulation of amyloid plaques around neuronal cells is considered a critical pathogenetic event and, in most cases, a hallmark of the path...