Single-cell multiomics sequencing and analyses of human colorectal cancer

• Published in: Science (American Association for the Advancement of Science) Vol. 362; no. 6418; pp. 1060 - 1063
• Main Authors: Bian, Shuhui, Hou, Yu, Zhou, Xin, Li, Xianlong, Yong, Jun, Wang, Yicheng, Wang, Wendong, Yan, Jia, Hu, Boqiang, Guo, Hongshan, Wang, Jilian, Gao, Shuai, Mao, Yunuo, Dong, Ji, Zhu, Ping, Xiu, Dianrong, Yan, Liying, Wen, Lu, Qiao, Jie, Tang, Fuchou, Fu, Wei
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 30.11.2018
• Subjects: Biological evolution; Cancer; Colon; Colon cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Demethylation; Deoxyribonucleic acid; DNA; DNA Methylation; Epigenomics - methods; Female; Gene expression; Genetics; Genome-Wide Association Study; Genomes; Genomic instability; Heterochromatin; Heterogeneity; Histones; Humans; Male; Metastases; Metastasis; Mutation; Nucleotide sequence; Patients; Sequence Analysis, DNA; Single-Cell Analysis - methods; Stability; Tumors

To better design treatments for cancer, it is important to understand the heterogeneity in tumors and how this contributes to metastasis. To examine this process, Bian et al. used a single-cell triple omics sequencing (scTrio-seq) technique to examine the mutations, transcriptome, and methylome with...