The ATPases CopA and CopB both contribute to copper resistance of the thermoacidophilic archaeon Sulfolobus solfataricus

• Published in: Microbiology (Society for General Microbiology) Vol. 158; no. Pt 6; pp. 1622 - 1633
• Main Authors: VÖLLMECKE, Christian, DREES, Steffen L, REIMANN, Julia, ALBERS, Sonja-Verena, LÜBBEN, Mathias
• Format: Journal Article
• Language: English
• Published: Reading Society for General Microbiology 01.06.2012
• Subjects: Adenosine Triphosphatases - genetics; Adenosine Triphosphatases - metabolism; Archaeal Proteins - genetics; Archaeal Proteins - metabolism; Bacteriology; Biological and medical sciences; Cation Transport Proteins - genetics; Cation Transport Proteins - metabolism; Copper - metabolism; Copper-Transporting ATPases; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Enzymologic; Microbiology; Miscellaneous; Molecular Sequence Data; Phylogeny; Reactive Oxygen Species - metabolism; Sulfolobus solfataricus - classification; Sulfolobus solfataricus - enzymology; Sulfolobus solfataricus - genetics; Sulfolobus solfataricus - metabolism; Acidophily; Enzyme; Archaeobacteria; Adenosinetriphosphatase; Thermophily; Sulfolobus solfataricus; Heavy metal; Resistance; Sulfolobaceae; Bacteria; Hydrolases; Sulfolobales; Copper

Certain heavy metal ions such as copper and zinc serve as essential cofactors of many enzymes, but are toxic at high concentrations. Thus, intracellular levels have to be subtly balanced. P-type ATPases of the P(IB)-subclass play a major role in metal homeostasis. The thermoacidophile Sulfolobus sol...