Gabapentin inhibits the analgesic effects and nerve regeneration process induced by hepatocyte growth factor (HGF) in a peripheral nerve injury model: Implication for the use of VM202 and gabapentinoids for peripheral neuropathy

• Published in: Molecular and cellular neuroscience Vol. 122; p. 103767
• Main Authors: Lee, Nayeon, Nho, Boram, Ko, Kyeong Ryang, Kim, Sunyoung, Lee, Junghun
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2022
• Subjects: c-Met; Gabapentin; HGF; Nerve regeneration; Neuropathic pain; pCK-HGF-X7 (VM202); c-Met; pCK-HGF-X7 (VM202); Gabapentin; HGF; Nerve regeneration; Neuropathic pain

Hepatocyte growth factor (HGF) is a multifunctional protein that plays a critical role in the angiogenic, neurotrophic, antifibrotic, and antiapoptotic activities of various cell types. It has been previously reported that intramuscular injection of pCK-HGF-X7 (or VM202), a plasmid DNA designed to e...