All-in-one magnetic beads: Searching, capturing and simultaneous detection of dual tumor related proteins in real samples
Simultaneous assay of multiple tumor marker proteins is of great importance for accurate diagnosis of cancer because most of cancers are usually related to various tumor-related proteins. In this work, we prepared yellow-colored carbon dots (y-CDs) and blue-colored carbon dots (b-CDs) for simultaneo...
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| Published in | Sensors and actuators. B, Chemical Vol. 369; p. 132330 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Lausanne
Elsevier B.V
15.10.2022
Elsevier Science Ltd |
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| Abstract | Simultaneous assay of multiple tumor marker proteins is of great importance for accurate diagnosis of cancer because most of cancers are usually related to various tumor-related proteins. In this work, we prepared yellow-colored carbon dots (y-CDs) and blue-colored carbon dots (b-CDs) for simultaneous detection of carcinoembryonic antigen (CEA) and cancer antigen125 (CA125) based on the antifouling magnetic beads (MBs) in real samples. Two sandwich structures were constructed by MBs modified with aptamer 1(Apt1) of proteins and aptamer 2(Apt2) tagged with CDs in the presence of target proteins. After CDs were cut off and separated, the fluorescence intensities at 430 nm (b-CDs) and 550 nm (y-CDs), relating to quantities of two proteins, were measured at a single excitation wavelength, obtaining the detection limits of 0.11 ng mL−1 (CEA) and 0.57 U mL−1 (CA125) respectively. Due to the target specific searching, recognition, capturing with aptamers, magnetic separation and antifouling property of peptides, the simultaneous differentiating and assaying CEA and CA125 in human serum can be easily operated, and results reveal a good correlation with data from the electrochemiluminescent (ECL) immunoassay in hospitals, demonstrating the promising candidate for clinical diagnosis of ovarian cancer.
In this work, yellow-colored carbon dots (y-CDs) and bule-colored dots (b-CDs) were prepared for the simultaneous detection of carcinoembryonic antigen (CEA) and cancer antigen125 (CA125) based on the antifouling magnetic beads (MBs) in real samples. The detection result has a good correlation with data from the electrochemiluminescent (ECL) immunoassay used in hospitals, demonstrating the promising candidate for clinical diagnosis of ovarian cancer. [Display omitted]
•Searching, capturing and assay of CEA and CA125 can be simultaneously accomplished by a magnetic bead.•Different proteins are distinguished simultaneously using two colored fluorescence carbon dots at a single excitation.•Antifouling performances of peptides on the sensing surface is applied to improve assay accuracy in real serum samples.•Strategy proves a promising candidate for diagnosis of ovarian cancer by correlation analysis with clinical method. |
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| AbstractList | Simultaneous assay of multiple tumor marker proteins is of great importance for accurate diagnosis of cancer because most of cancers are usually related to various tumor-related proteins. In this work, we prepared yellow-colored carbon dots (y-CDs) and blue-colored carbon dots (b-CDs) for simultaneous detection of carcinoembryonic antigen (CEA) and cancer antigen125 (CA125) based on the antifouling magnetic beads (MBs) in real samples. Two sandwich structures were constructed by MBs modified with aptamer 1(Apt1) of proteins and aptamer 2(Apt2) tagged with CDs in the presence of target proteins. After CDs were cut off and separated, the fluorescence intensities at 430 nm (b-CDs) and 550 nm (y-CDs), relating to quantities of two proteins, were measured at a single excitation wavelength, obtaining the detection limits of 0.11 ng mL−1 (CEA) and 0.57 U mL−1 (CA125) respectively. Due to the target specific searching, recognition, capturing with aptamers, magnetic separation and antifouling property of peptides, the simultaneous differentiating and assaying CEA and CA125 in human serum can be easily operated, and results reveal a good correlation with data from the electrochemiluminescent (ECL) immunoassay in hospitals, demonstrating the promising candidate for clinical diagnosis of ovarian cancer. Simultaneous assay of multiple tumor marker proteins is of great importance for accurate diagnosis of cancer because most of cancers are usually related to various tumor-related proteins. In this work, we prepared yellow-colored carbon dots (y-CDs) and blue-colored carbon dots (b-CDs) for simultaneous detection of carcinoembryonic antigen (CEA) and cancer antigen125 (CA125) based on the antifouling magnetic beads (MBs) in real samples. Two sandwich structures were constructed by MBs modified with aptamer 1(Apt1) of proteins and aptamer 2(Apt2) tagged with CDs in the presence of target proteins. After CDs were cut off and separated, the fluorescence intensities at 430 nm (b-CDs) and 550 nm (y-CDs), relating to quantities of two proteins, were measured at a single excitation wavelength, obtaining the detection limits of 0.11 ng mL−1 (CEA) and 0.57 U mL−1 (CA125) respectively. Due to the target specific searching, recognition, capturing with aptamers, magnetic separation and antifouling property of peptides, the simultaneous differentiating and assaying CEA and CA125 in human serum can be easily operated, and results reveal a good correlation with data from the electrochemiluminescent (ECL) immunoassay in hospitals, demonstrating the promising candidate for clinical diagnosis of ovarian cancer. In this work, yellow-colored carbon dots (y-CDs) and bule-colored dots (b-CDs) were prepared for the simultaneous detection of carcinoembryonic antigen (CEA) and cancer antigen125 (CA125) based on the antifouling magnetic beads (MBs) in real samples. The detection result has a good correlation with data from the electrochemiluminescent (ECL) immunoassay used in hospitals, demonstrating the promising candidate for clinical diagnosis of ovarian cancer. [Display omitted] •Searching, capturing and assay of CEA and CA125 can be simultaneously accomplished by a magnetic bead.•Different proteins are distinguished simultaneously using two colored fluorescence carbon dots at a single excitation.•Antifouling performances of peptides on the sensing surface is applied to improve assay accuracy in real serum samples.•Strategy proves a promising candidate for diagnosis of ovarian cancer by correlation analysis with clinical method. |
| ArticleNumber | 132330 |
| Author | Gong, Yan Ding, Caifeng Zou, Mingjing Sun, Xinxin |
| Author_xml | – sequence: 1 givenname: Mingjing surname: Zou fullname: Zou, Mingjing organization: College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China – sequence: 2 givenname: Yan surname: Gong fullname: Gong, Yan organization: College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China – sequence: 3 givenname: Xinxin surname: Sun fullname: Sun, Xinxin organization: College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China – sequence: 4 givenname: Caifeng surname: Ding fullname: Ding, Caifeng email: dingcaifeng@qust.edu.cn organization: College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China |
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| Keywords | Dual-colored carbon dots Magnetic beads Carcionembryonic antigen Antifouling Cancer antigen 125 |
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| SubjectTerms | Antifouling Antigens Beads Cancer Cancer antigen 125 Carbon dots Carcionembryonic antigen Diagnosis Dual-colored carbon dots Electrochemiluminescence Immunoassay Magnetic beads Magnetic properties Magnetic separation Peptides Proteins Sandwich structures Searching Tumors |
| Title | All-in-one magnetic beads: Searching, capturing and simultaneous detection of dual tumor related proteins in real samples |
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