Prevention of Staphylococcus aureus endophthalmitis with topical gatifloxacin in a rabbit prophylaxis model

• Published in: Journal of ocular pharmacology and therapeutics Vol. 22; no. 2; p. 132
• Main Authors: de Castro, Luis E Fernández, Sandoval, Helga P, Bartholomew, Luanna R, Vroman, David T, Solomon, Kerry D
• Format: Journal Article
• Language: English
• Published: United States 01.04.2006
• Subjects: Administration, Topical; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Antibiotic Prophylaxis; Disease Models, Animal; Endophthalmitis - microbiology; Endophthalmitis - prevention & control; Fluoroquinolones - administration & dosage; Fluoroquinolones - therapeutic use; Instillation, Drug; Rabbits; Staphylococcal Infections - microbiology; Staphylococcal Infections - prevention & control; Staphylococcus aureus - drug effects

The aim of this study was to investigate the prophylactic use of 0.3% gatifloxacin drops to prevent endophthalmitis in a rabbit model. Forty (40) New Zealand white rabbits were randomly placed into group A (20 rabbits) where they received 1 drop of 0.3% gatifloxacin in their right eye every 15 min (...