Computational prediction and interpretation of cell-specific replication origin sites from multiple eukaryotes by exploiting stacking framework

• Published in: Briefings in bioinformatics Vol. 22; no. 4
• Main Authors: Wei, Leyi, He, Wenjia, Malik, Adeel, Su, Ran, Cui, Lizhen, Manavalan, Balachandran
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2021; Oxford Publishing Limited (England)
• Subjects: Algorithms; Cell culture; Computer applications; Deoxyribonucleic acid; DNA; DNA biosynthesis; Eukaryotes; Learning algorithms; Machine learning; Nucleic acids; Physicochemical properties; Prediction models; Replication; Replication origins; Training; model interpretability; eXtreme Gradient Boosting; feature extraction; stacking strategy; origin of replication site

Abstract Origins of replication sites (ORIs), which refers to the initiative locations of genomic DNA replication, play essential roles in DNA replication process. Detection of ORIs’ distribution in genome scale is one of key steps to in-depth understanding their regulation mechanisms. In this study...