Penetration of [ 3H]T-2 toxin through excised human and guinea-pig skin during exposure to [ 3H]T-2 toxin adsorbed to corn dust

• Published in: Food and chemical toxicology Vol. 22; no. 11; pp. 893 - 896
• Main Authors: Kemppainen, B.W., Riley, R.T., Pace, J.G.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.11.1984; New York, NY Elsevier Science
• Subjects: Absorption; Adsorption; Animals; Biological and medical sciences; Chromatography, Thin Layer; corn; Dust; dusts; Guinea Pigs; hides and skins; Humans; In Vitro Techniques; Male; Medical sciences; penetration; Plant poisons toxicology; Sesquiterpenes - metabolism; Skin - metabolism; Species Specificity; T-2 Toxin - metabolism; Toxicology; trichothecenes; Tritium; Zea mays; TLC = thin-layer chromatography; HT-2 = HT-2 toxin; T-2 = T-2 toxin; Human; Rodentia; Mycotoxin; Occupational exposure; Metabolism; In vitro; Vertebrata; Mammalia; Absorption; Guinea pig; Animal; Skin; Topical administration

An in vitro test system was used to measure the penetration of [ 3H]T-2 toxin through human epidermis, human whole skin (isolated dermis and epidermis), and through guinea-pig whole skin. To simulate the conditions which occur when agricultural workers are exposed to corn dust contaminated with T-2...