Changes in aspartate metabolism in the medial‐prefrontal cortex of nicotine addicts based on J‐edited magnetic resonance spectroscopy

• Published in: Human brain mapping Vol. 44; no. 18; pp. 6429 - 6438
• Main Authors: Yu, Miaomiao, Lin, Liangjie, Xu, Ke, Xu, Man, Ren, Jianxin, Niu, Xiaoyu, Gao, Xinyu, Zhang, Mengzhe, Yang, Zhengui, Dang, Jinghan, Tao, Qiuying, Han, Shaoqiang, Wang, Weijian, Cheng, Jingliang, Zhang, Yong
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.12.2023
• Subjects: Addictions; Addictive behaviors; Addicts; Alzheimer's disease; aspartate; Autism; Brain; Correlation; Creatine; Decision making; Drug addiction; Drug dependence; Impulsive behavior; Impulsivity; Inositol; Inositols; Magnetic resonance imaging; Magnetic resonance spectroscopy; medial‐prefrontal cortex; Medical imaging; Mental disorders; Metabolism; Metabolites; N-Acetylaspartate; Neuroimaging; Nicotine; nicotine addiction; Parkinson's disease; Prefrontal cortex; Schizophrenia; Smoking; Spectroscopy; Spectrum analysis
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.26519

This study aims to explore the changes of the aspartate (Asp) level in the medial‐prefrontal cortex (mPFC) of subjects with nicotine addiction (nicotine addicts [NAs]) using the J‐edited 1H MR spectroscopy (MRS), which may provide a positive imaging evidence for intervention of NA. From March to Aug...