Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice

• Published in: Journal of pineal research Vol. 65; no. 2; pp. e12489 - n/a
• Main Authors: Lee, Fan‐Yen, Sun, Cheuk‐Kwan, Sung, Pei‐Hsun, Chen, Kuan‐Hung, Chua, Sarah, Sheu, Jiunn‐Jye, Chung, Sheng‐Ying, Chai, Han‐Tan, Chen, Yi‐Ling, Huang, Tien‐Hung, Huang, Chi‐Ruei, Li, Yi‐Chen, Luo, Chi‐Wen, Yip, Hon‐Kan
• Format: Journal Article
• Language: English
• Published: England 01.09.2018
• Subjects: angiogenesis; endothelial cells; endothelial progenitor cells; ischemia; melatonin; oxidative stress; endothelial cells; melatonin; angiogenesis; endothelial progenitor cells; oxidative stress; ischemia

We tested the hypothesis that daily melatonin treatment protects endothelial lineage and functional integrity against the aging process, oxidative stress/endothelial denudation (ED), and toxic environment and restored blood flow in murine critical limb ischemia (CLI). In vitro study using HUVECs, in...